Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"ISG"”.
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Investigation of the interactions between Trypanosoma congolense invariant surface glycoproteins and components of the mammalian immune system
… interface. Invariant surface glycoproteins (ISGs) are a large family of cell surface proteins with recent expansion and diversification in *Trypanosoma congolense*. *Trypanosoma brucei* ISG65 is known to be a receptor for complement C3, and *T. brucei* ISG75 has been implicated in …
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Rhizoctonia disease of soybeans and its potential biological control by Bacillus megaterium
Three intraspecific groups (ISGs), ISG-2A, 2B, and 2C, of Rhizoctonia solani were proposed for 14 isolates of anastomosis group (AG) 2 based on isozyme analysis. These ISGs were fixed for deferent genotypes at aco locus and seemed to reflect genetic affinities. A highly virulent field isolate, …
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Characteristics of principal leadership influencing school culture.
… involved in the International Schools Group (ISG) in Saudi Arabia. A secondary purpose of this study is to inform ISG educational leaders about the perspectives of their respective stakeholder groups regarding principal leadership characteristics and school culture. Four research questions …
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Elucidating the functional states of tumor-resident dendritic cells that drive productive anti-tumor immunity
… an interferon-stimulated gene signature (ISG+ DC) that was enriched in regressor tumors. Like DC1, ISG+ DC was capable of driving anti-tumor CD8+ T cell immunity. However, unlike cross-presenting DC1, ISG+ DC activated T cells by crossdressing with pre-formed tumor-derived peptide-MHC …
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Designing and Implementing Hard Drive Inventory Policies for Enterprise Computing Solutions
… of the Dell-EMC Infrastructure Solutions Group (ISG) has maintained large inventory buffers to deal with high demand uncertainty and minimize part shortages. High product configurability and complex product structures continue to present challenges to effectively managing component inventory. In …
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Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
… Biosystems) for SNPs in IFNB1, OAS-1, and ISG-15 to establish a relationship between SNPs and clinical complications post-transplantation. Quantitative real-time polymerase chain reaction (QPCR) was also run to determine the relationship between SNPs or disease state and the level of RNA …
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The Interferon Stimulated Gene Product Lymphocyte Antigen 6 Complex, Locus E Promotes Entry of a Subset of Diverse RNA Viruses and Inhibits Infection by Coronaviruses
… by inducing hundreds of IFN-stimulated genes (ISG). In a screen to identify novel antiviral factors, the Schoggins lab unexpectedly uncovered a subset of genes that enhanced viral infection. Here, I describe my personal efforts to study lymphocyte antigen 6, locus E (LY6E), a protein which was …
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New Roles for Mitochondria in Shaping Antiviral and Stress Responses
… genes, known as interferon-stimulated genes (ISG)s, are differentially regulated at the protein level by metabolites in type I and type II IFN-primed human cells. Interestingly, galactose, which enhances mitochondrial activity, triggers selective protein degradation of the ISG IRF1. Notably, …
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Optimization of a magnetically saturable interior permanent-magnet synchronous machine drive
… for an automotive integrated starter/generator (ISG) that is rated at 4 to 6 kW during generating operation. This ISG machine is mounted in a direct-drive mechanical configuration on the engine crankshaft. Agreement between the saturable LPM and FEA calculations for q- and d- axis inductances and …
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Biological Functions of Intracellular Hepatitis B e Antigen
… and expression of interferon stimulated genes (ISGs) upon interferon-alpha (IFN- α) stimulation. Furthermore, in line with this, RNA-seq analysis of ISG induction profile from IFN-α treated patients showed that HBeAg(+) patients exhibited reduced and weak antiviral ISG upregulations compared to …
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Microevolutionary studies in Marasmiellus praeacutus and Collybia subnuda, two litter-decomposing basidiomycetes
… RNA-encoding gene family. Intersterility group (ISG) 1 is usually found on oak leaf litter, and ISG 2 is usually found associated with oak wood. Collection records, mating crosses, and spore-catching experiments indicate that the two ISGs are distributed sympatrically throughout the sampled …
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Characterization of the Antiviral Effector IFI6
… expression of interferon stimulated genes (ISGs) are major contributors to the innate immune response, which establish an antiviral state in the cell. Flaviviruses such as dengue virus, Zika virus, and West Nile virus rely intimately on host pathways for completing a replication cycle, and …
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Effects of Preovulatory Estradiol Concentration on Embryo Survival and Pregnancy Establishment in Beef Cows
… CON. Expression of interferon stimulated genes (ISG) was used as a marker for pregnancy on d 17, 19, 21, and 28 and pregnancy-specific protein B (PSPB) was used as a marker for pregnancy on d 22-28. Transrectal ultrasonography was used on d 29 to diagnose pregnancy. When ISG expression was used …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
… of interferon (IFN)-stimulated genes (ISGs), although this does not contribute to the cell death phenotype. Rather than occurring through a canonical IFN response, CBF-β loss-induced ISG expression relies on the direct transcriptional activity of IFN Regulatory Factor 3 (IRF3) and its …
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The Effects of Preovulatory Estradiol on the Uterine Environment and Conceptus Survival From Fertilization to Maternal Recognition of Pregnancy
… expression of interferon-stimulated genes (ISG): ISG-15, OAS-1, and MX2. For replicate 2, total cellular RNA was extracted from caruncular (CAR) and intercaruncular (INCAR) endometrial tissue to determine relative abundance of select glucose transporters (SLC2A1, SLC2A4, SLC2A5, and SLC5A1). …
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Signal Transduction and Transcriptional Regulation in the Response to Type I Interferon
… a specific set of interferon stimulated genes (ISGs). In this thesis, I have addressed the cellular strategies employed to transmit specific cell surface signals across compartmental boundaries, ultimately resulting in specific transcriptional modulation in the nucleus. The analysis of the 5' …
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Biologically-inspired Network Memory System for Smarter Networking
… operations as the “Internet Semantics Gap (ISG)”. We hypothesize that endowing the Internet and next generation networks with a “memory” system that provides data and semantics management would help resolve the ISG and enable “Internet Intelligence”. We seek to enable networked entities, at …
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Predicting radioactive waste glass properties with machine learning and modelling
… MW glass and newly measured (7 day) short-term ISG/MW25 free pH and (27 day) ISG/Ca-Zn Tris-Tris HCl buffered pH dissolution. The short-term free pH experiments complemented longer-term leaching experiments, and TEM imaging of 90 °C MW25 samples revealed significant alteration, even after 1 day …
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Spatio-temporal slope measurement of short wind waves under the influence of surface films at the Heidelberg Aeolotron
A novel, high resolution Imaging Slope Gauge (ISG) at the Heidelberg Aeolotron is presented. The instrument allows measurements of the two-dimensional slope of short wind-driven water waves at unprecedented temporal and spatial resolution. Wave number spectra are measured up to k = 13000 rad/m with …
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Identification and Characterization of a New E1 That Activates Ubiquitin and FAT10
… in the activation of the ubiquitin-like protein ISG-15 (E1-L1). E1-L2 activates both ubiquitin and FAT10, a ubiquitin-like protein. Interestingly, E1-L2 can transfer ubiquitin to only a subset of E2 enzymes, Ubc5 and Ubc13, but not Ubc3 and E2-25K, suggesting that E1-L2 may function in certain …
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