Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"IRSp53"”.
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Investigations into membrane protrusions mediated by IRSp53 IMD
… it forms for a wide range of processes. IRSp53 acts downstream of cytoskeleton master regulators Rac and Cdc42 in the formation of lamellipodia and filopodia, respectively. IRSp53 interacts with many other effectors in the formation of these structures, via various protein interaction …
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3D Coiling at the Protrusion Tip: New Perspectives on How Cancer Cells Sense Their Fibrous Surroundings
… tyrosine kinase Substrate protein of 53 kDa (IRSp53) as a key regulator of protrusive activity with IRSp53 knockout (KO) cells exhibiting significantly slower protrusion dynamics and diminished coil width compared to their wild-type (WT) counterparts. We demonstrate that the hindered …
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Toca-1 driven actin polymerisation at membranes
… PH domain in lamellipodin, or I-BAR protein in IRSp53) and a domain which interacts with actin regulatory proteins (such as the SH3 domain of IRSp53, which binds Ena and VASP). I investigated the contribution of the F-BAR protein Toca-1 in linking actin polymerisation to membranes, by …
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Investigation of the actin-membrane interaction at the leading edge and its influence on membrane diffusion
… indicate that actin regulating proteins such as IRSp53 are influenced by the restricted diffusion zone at the leading edge. We propose that the lipid diffusion barrier traps regulatory proteins at the leading edge and can therefore be seen as a positive feedback mechanism for actin polymerisation.
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Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
… Here, chronic MPH increased Arc, IRSp53/58, Cdc42, and Arp2 levels in the: striatum, nucleus accumbens and hippocampus. The MPH-induced increase of these synaptic plasticity-associated markers in these brain regions may induce changes in dendritic spine morphology, as well as in …