Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"IRS1"”.
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Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… adaptor protein, Insulin Receptor Substrate 1 (IRS1), and suggests multi-faceted dysregulation of IGF1R/IRS1 signalling in ageing B cell progenitors. IGF1R signalling functions in cellular growth and proliferation in numerous mammalian tissues, but its role in normal B cell development is poorly …
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The Potential Role of Insulin (and Stress Response) Pathway Components In Breast Cancer Development and Progression
… pathway genes, IGF1, TSC1, IGFBP2, IRS1, TCF7L2, IGF1R, and PPARA, if significantly associated with tumor receptor status, provide evidence for a connection between insulin metabolism and the determination of breast tumor subtypes. The CC genotype of the TSC1 polymorphism rs7874234 …
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MECHANISMS OF SUBSTRATE DEGRADATION AND RECRUITMENT BY CULLIN E3 LIGASES
… the degradation of insulin receptor substrate 1 (IRS1) by the Cullin5 E3 ligase, and found that the basal and signal-induced degradation of IRS1 protein is not dependent on Cullin5. We next investigated the regulation of the Cullin1 E3 ligase substrate receptor module, consisting of the Skp1 …
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Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scan and Candidate Genes to Genome Wide Association Studies
… an earlier genome wide linkage study; 2) studied IRS1 as a candidate gene for T2D and MetS and 3) studied the role of 28 genes, earlier identified in candidate gene- and genome wide association studies (GWAS) as susceptibility genes for T2D, in MetS. In study I, extensive fine mapping by …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… levels of active insulin receptor substrate 1 (IRS1) are reduced in NCAM2-deficient neurons. In transfected CHO cells, NCAM2 increases the levels and activity of the insulin receptor. Further, NCAM2 deficiency affects the levels of the insulin and IGF1 receptors and IRS1 during early postnatal …
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A detailed infrared study of the star forming region NGC2071 IRS
… and discussed individually and collectively. IRS1 is a highly polarized pre-main-sequence star which is most likely the generating source of the bipolar outflow; IRS2, 4 and 6 are stellar-like objects with low polarization; IRS4, and IRS6 are background stars showing some reddening due to dust …
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Genome-wide cross-cancer analysis reveals the importance of bimodal microRNA in predicting patient survival and drug response
… box O3 (FOXO3) and insulin receptor substrate 1 (IRS1). Because of the activating role of FOXO3 and IRS1 in mitogen-activated protein kinase (MAPK) signaling, levels of phosphorylated extracellular signal-regulated kinase (p-ERK) were also measured. Drug induction of p-ERK was partially mitigated …
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Regulation of skeletal myogenesis by the mTOR signaling network
… by increased Akt activation, elevated IRS1 iv protein levels, and decreased Ser307 (human Ser312) phosphorylation on IRS1. Finally, IRS1 knockdown eliminated the enhancement in differentiation elicited by raptor or Rheb knockdown, suggesting that IRS1 is a critical mediator of the …
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The impact of glucocorticoids upon the insulin sensitivity of skeletal muscle
… signalling cascade at several critical points: IRS1, PI3K and AS160. Furthermore, we have described a novel role of GC, and GCs with insulin, in the regulation of intramyocellular lipid metabolism, which may underpin GC-induced insulin resistance in this tissue. We have also highlighted the …
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H107[alpha] recombination-line emission, 4800-MHz and 1666-MHz continuum emission in the HII region RCW38
… the peak in the 10[mu]m emission known as IRS1 (Frogel et al. 1974) apparent in both observations. From calculations of continuum and line parameters, we estimate the spectral type of the ionizing source for the region to be an 05/06 star which is consistent with the spectral type of IRS2.
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Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
… heterodimers with either IRS1 or IRS2. This in turn resulted in impaired downstream signalling as indicated by low adipogenic efficiency. Cells and tissues isolated from Pik3r1$^{WT/Y657X}$ knock-in mice also demonstrated decreased insulin-stimulated Akt phosphorylation. …
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The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
… and in vitro. The binding sites for the IRAK1-IRS1 biochemical interaction are IRS-1's PH domain and IRAK-1's proline-rich LWPPPP motif. Our studies also indicate that IRAK-1 is involved with the negative regulation of glycogen synthesis through inhibiting PI3K-Akt signaling pathway and thus …
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The identification of the mTOR-regulated phosphoproteome and a mediator of feedback inhibition to P13K-Akt
… inhibition results in changes in Grb1O and IRS1 phosphorylation which partially reactivates Akt in TSC2-null cells, chronic mTORC1 inhibition causes Grbl 0 destabilization, IRS protein stabilization, and a complete resensitization of Akt to insulin and IGF-1. These changes in Grbl 0 and IRS …
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Transcriptome activity of human cytomegalovirus (strain Merlin) in fibroblasts, epithelial cells and astrocytes
… cells, 13 HCMV ORFs (UL4, UL16, UL45, UL148, IRS1, US11, US12, US13, US14, US15, US18, US19, US20), were found to be differentially expressed, and this was confirmed by examination of the expression kinetics of the individual genes. When the microarray data from infected HFFF and U373Mg cells …
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Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
… and increased protein expression of IRS1, Akt, and AS160 phosphorylation compared to severely obese subjects. The results from this study suggest that both resveratrol and contractile activity alter the inherent characteristics of human skeletal muscle in severely obese individuals, …
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Role of PARK2Gene in Maintenance of Pancreatic Beta Cell Functions
… Pdx1, Mafa, Mafb, Nkx2-2, Nkx6-1, Pax4, and Irs1 that encode the pancreatic transcription factors were significantly decreased in the Park2-depleted INS-1 β-cells. In addition, the INS-1 β-cells lacking parkin exhibited decreased intracellular ATP level and mitochondrial membrane potential …
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Transcriptional adaptation of adipose tissue in dairy cows in response to energy overfeeding
… increased and decreased insulin-stimulated IRS1 tyrosine phosphorylation in AT in pre- and postpartum, respectively, which may contribute to differentially regulated lipolysis in these overfed animals. (For contents in chapter 6)
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… of ER and its target genes like IGFBP4, IGFBP5, IRS1 that are a part of the IGF signaling pathway and are also implicated in a significant number of malignancies. Whole flaxseed diet also decreased the expression of the anti-apoptotic protein, BCL2L1 possibly by reducing the activation of the …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… cancer. TCGA pan-cancer analyses report *IRS1* downregulation and *PLEKHS1* upregulation in several primary carcinomas, compared to healthy tissue. In prostate, endometrial and breast cancers, *PLEKHS1* expression correlates with PI3K pathway activation and alterations in key pathway genes …
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