NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 26 for “"IRS-1"”.

  1. Quantitative analysis of carbon fluxes for fat biosynthesis in wild-type and IRS-1 knockout brown adipocytes

    Yoo, Hyun-Tae, 1973-Massachusetts Institute of Technology2005

    … to intervention of the diseases. As a first step to quantitative investigation of lipogenic fluxes from various carbon sources as related to insulin signaling, relative contribution of glucose, glutamine, and acetoacetate to fat biosynthesis in wild-type (WT) and insulin receptor …

    mit Repository record

  2. The effects of linoleate on insulin action in skeletal muscle cells

    Cazzolli, RosannaUNSW, Sydney2005

    … the inhibition of tyrosine phosphorylation of IRS-1 by its prior serine/threonine (ser/thr) phosphorylation. IRS-1 ser/thr phosphorylation has been linked to the dissociation of IRS-1 from the insulin receptor and PI3K, and its degradation via a proteasome-dependent pathway. Studies in animal …

    unsw Repository record

  3. Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling

    Cengel, Keith AlbertUniversity of Illinois at Urbana-Champaign2015

    … a novel serine kinase that can phosphorylate IRS-1 and reduce its ability to act as a substrate for insulin and interferon alpha (IFNalpha) receptors. PI 3-kinase is shown to associate with a wortmannin insensitive 76 kDa serine phosphoprotein (pp76) distinct from the p85 subunit of PI …

    uiuc Repository record

  4. Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death

    이, 성미2011

    … 2 2. 유전자 발현 2 3. 신호 전달 3 C. 고농도 포도당과 지방산에 의한 IRS-1 tyrosine 기 감소의 원인 4 1. IR (insulin receptor) 에 의한 IRS-1 tyrosine기 인산화 감소 4 2. IRS-1 Serine 인산화가 증가시킴으로 인해 IRS-1 tyrosine 인산화 를 감소 5 3. PTPs에 의해서 IRS-1 tyrosine 인산화가 감소 7 D. IKK 10 E. 연구 목적 13 Ⅱ. 재료 및 방법 (혹은 연구대상 및 방법) 14 A. 재료 14 1. 재료 14 B. …

    ajou Repository record

  5. PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D

    Kouassi, Kouassi TataCreighton University2016

    … phosphorylation of insulin receptor substrate (IRS) has been one of the most common pathways in the establishment of insulin resistance (IR). Novel Protein kinase C (nPKC), is solely activated by diacylglycerol (DAG). Diacylglycerol has been found to be increased in the liver during NAFLD. …

    creighton Repository record

  6. Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease

    Najem, DemaUniversité d'Ottawa / University of Ottawa2014

    … resistance in N2a-APP cells by phosphorylating IRS-1 at Ser612, inhibiting signaling to downstream targets. Aβ1-42-treated SHY exhibited similar IRS-1 phosphorylation at Ser612 and inflammatory response of JNK activation. Aβ1-42 caused down-regulation of neuro-protective/anti-inflammatory …

    ottawa-retro Repository record

  7. Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells

    Strle, KlemenUniversity of Illinois at Urbana-Champaign2015

    … enzymatic activity. Active JNK associates with IRS-1, and this is a possible mechanism by which TNFalpha, and C2-ceramide, suppress the IGF-I-induced tyrosine phosphorylation of IRS-1. Indeed, a novel peptide inhibitor of JNK (I-JNK), potently suppressed JNK enzymatic activity and the ability of …

    uiuc Repository record

  8. Effects of Rosemary Extract and Rosemary Extract Polyphenols on Skeletal Muscle Insulin Resistance

    Shamshoum, HeshamBrock University2018

    … Akt phosphorylation, while increased IRS-1 Ser636/639 phosphorylation indicating insulin resistance. In addition, HG+HI increased mTOR phosphorylation/activation. Importantly, treatment with RE (5 μg/ml) significantly restored the insulin-stimulated glucose uptake (HG + HI + RE + I: …

    brock Repository record

  9. Inhibition of Free fatty acid-Induced Insulin Resistance by Rosemary Extract: Investigation of the Mechanisms Involved

    Filip, VlavcheskiBrock University2018

    … palmitate increased serine phosphorylation of IRS-1 and significantly decreased the insulin-stimulated phosphorylation of Akt. These effects were completely abolished in the presence of rosemary extract. Additionally, we investigated the effect of palmitate and rosemary extract on the …

    brock Repository record

  10. The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation

    Fang, YoujiaVirginia Tech2009

    … data also indicate that IRAK-1 can interact with IRS-1 protein both in vivo and in vitro. The binding sites for the IRAK1-IRS1 biochemical interaction are IRS-1's PH domain and IRAK-1's proline-rich LWPPPP motif. Our studies also indicate that IRAK-1 is involved with the negative regulation of …

    vt Repository record

  11. The Effect of Weight Reduction on Chronic Inflammatory Molecules and Insulin Resistance in type 2 DM

    박, 지원2011

    … receptor(IR-β), insulin receptor substrate(IRS)-1, Akt, and GSK-3, PAC-zeta, lambda, theta, delta, alpha, beta phosphorylation before and after insulin stimulation in 15 normal control group and 13 type 2 DM group and follow up 6 month later in 8 case type 2 DM. In DM group, we try to weight …

    ajou Repository record

  12. RUOLO DEL RECETTORE GABAA NELLE CELLULE ALFA PANCREATICHE E SUO COINVOLGIMENTO NELLE FASI DI DESENSIBILIZZAZIONE INDOTTA DALLA LIPOTOSSICITA NEL DIABETE DI TIPO II.

    PAPPALARDO, ALESSANDRO ORAZIO GIOVANNIUniversità degli studi di Catania2015

    … (diminuzione della fosforilazione di IRS-1 e Akt), e riduzione dell’effetto inibitorio del GABA sulla secrezione di glucagone; inoltre anche la fosforilazione del canale GABAA indotta dal GABA era notevolmente ridotta dopo l'esposizione a palmitato. Nella seconda parte di questo lavoro …

    catania Repository record

  13. Effects of Zinc on the Insulin Receptor and Insulin Signal Transduction Pathway

    Tang, Xiao-HanUniversity of Illinois at Urbana-Champaign2015

    … signaling pathway was investigated. First, on the receptor binding, zinc decreased insulin binding to its receptor via decreasing the affinities for both the high and low affinity sites, without affecting the number of binding sites, and this effect was cell type specific. In contrast …

    uiuc Repository record

  14. Classification and modeling of trees outside forest in Central American landscapes by combining remotely sensed data and GIS

    Herrera-Fernandez, Bernal

    … area of 199,600ha. Both areas are covered by an IRS 1-D panchromatic image with 5.8m spatial resolution. In the case of Costa Rica, a smaller area of 127,500ha was also selected for investigation. Twenty-three scanned aerial photos cover this area. <br>For the purposes of this study, TOF …

    freiburg-diss Repository record

  15. Hyperinsulinemia and Hyperglycemia Contribute to Diabetic Complications Through Cytokine Resistance and Altered Macrophage Function

    Hartman, Matthew EdwardUniversity of Illinois at Urbana-Champaign2015

    … dependent impaired JAK tyrosine of IRS proteins; more specifically, only mTOR, one of the two known serine kinases in this pathway, is able to generate serine phosphorylation that has a negative effect on the ability of JAK1 to tyrosine phosphorylate IRS-1, (2) with conditions …

    uiuc Repository record

  16. Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease

    Coakley, Meghan F.University College Cork2014

    … Akt, IR, and the insulin receptor substrate (IRS-1) were examined in relationship to Aβ and tau pathology in the 3xTg-AD mouse model, which contains three mutant human transgenes associated with familial AD or dementia. The 3xTg-AD mouse develops Aβ and tau pathology in a spatiotemporal manner …

    cork Repository record

  17. Effects of physical activity levels and nutritional intake on skeletal muscle protein turnover and cellular signaling

    Erin Leigh GlynnThe University of Texas Medical Branch2010

    … phosphorylation of insulin receptor substrate 1 (IRS-1). In contrast, mTOR activity may play an important role in paraplegia-induced muscle atrophy as 10 weeks of paraplegia in rats significantly downregulated the mTOR pathway. In humans and compared to modest carbohydrate ingestion, higher …

    utmb Repository record

  18. Determining the effect of lipid nanoemulsions on insulin signaling and the inflammatory pathways at the Blood-Brain Barrier

    Nair, Sanjana2022

    … receptor (IR) and insulin resistance substrate (IRS)-1(1). The insulin resistance leads to a compensatory increase in circulating insulin leading to hyperinsulinemia. In addition to the impairment of insulin signaling, another hallmark of AD is lipid dysfunction(3). The lipid bilayer of the …

    umn Repository record

  19. The effect of lifestyle modification on the insulin-signaling cascade among subjects with impaired glucose tolerance

    송, 경은2011

    … receptor(IR-β), insulin receptor substrate(IRS)-1, Akt, and GSK-3 before and after insulin stimulation in subjects of normal control(n=15) and subjects with impaired glucose tolerance(n=14). We also assessed the protein level of atypical forms of protein kinase C(PKC-ξ/λ) and active form of …

    ajou Repository record

  20. Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells

    Shen, Wen-HongUniversity of Illinois at Urbana-Champaign2015

    … phosphorylate insulin receptor substrate-1 (IRS-1), to induce accumulation of both E2F-1 and cyclin A, to hyperphosphorylate retinoblastoma (RB), and to induce enzymatic activity and association of Cdk2 with cyclin A. The cytostatic property of these cytokines was also shown by their ability …

    uiuc Repository record

Page 1 of 2