Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"IRP1"”.
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Die Bedeutung der "High-Pathogenicity Island" (HPI) für kommensale und uropathogene Escherichia coli
… im Vergleich zu den isogenen Mutanten Mutaflor® irp1 (Mutante der Siderophorsynthese) und Mutaflor® fyuA (Mutante des Siderophorrezeptors) in vivo untersucht. Dabei ergab sich eine signifikant höhere Kolonisierungsfähigkeit des Ausgangsstammes E. coli Mutaflor® gegenüber der fyuA-Mutanten. Durch …
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Elucidating the role of Mitoferrin (Mfrn), Iron Regulatory Proteins (IRP1 and IRP2) and Hephaestin (Heph) in Iron Metabolism by tagSNP and Protein-Protein Interaction (PPI) analysis
Precisely how Hephaestin (Heph) facilitate iron release from cells is poorly understood. The work in this thesis tried to establish the role of different iron metabolic proteins, Mitoferrin (Mfrn), IRPs and Heph in iron homeostasis. Analysis of 18 tagSNPs in the Mfrn gene was carried out in an …
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Molecular responses of iron regulatory proteins to iron overload in human liver
… HH. Protein levels of iron regulatory protein 1 (IRP1), a known regulator of iron uptake and storage in cells, were found to be consistently down-regulated in the liver of patients with HFE-related HH and also in a human hepatoma cell line exposed to ferric ammonium citrate. The intracellular …
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Misregulation of Iron Handling Proteins in Excitotoxic Brain Injury
… hippocampus.A sustained, upregulation of IRP1, IRP2, DMT1 and -IRE DMT1 protein was detected in astrocytes in the kainate lesioned hippocampus. An increase in ferritin expression, and increased level of ferric iron and ferrous iron were also observed in microglia and oligodendrocytes in …
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Iron regulates mRNA translation initiation through RNA iron responsive element (IRE)
… eIF4F/IRE-RNA has a much longer life time than IRP1/IRE-RNA which suggests both kinetics and stability of the complexes are important. 7. eIF4G, a subunit of eIF4F, binds to IRE-RNA without other subunits. A novel regulatory mechanism is proposed where metabolic iron (Fe<sup>2+</sup>) induces …