Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"IRF8"”.
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
… dependent on interferon regulatory factor 8 (IRF8). NLRC4-mediated caspase-1 activation and subsequent production of the inflammasome-dependent cytokines IL-1β and IL-18 and cell death were impaired in IRF8-deficient cells. IRF8 mediated the transcription of genes encoding NAIPs, the receptors …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… factor Interferon Regulatory Factor 8 (IRF8) as the specification factor of dendritic cell (DC) commitment in early phagocyte precursors. Employing an IRF8 reporter mouse, I showed the distinct Irf8 expression in haematopoietic lineage diversification and isolated a novel bone marrow …
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Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
… both CD4 and CD8 T cells. Transcription factors IRF8 and IRF4, in cDC1s and cDC2s respectively, mediate this suppression of inflammasome activation by limiting the expression of inflammasome-associated genes. Additionally, overexpression of either of IRF4 or IRF8 is sufficient to inhibit …
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WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?
… for WT1. Interferon regulatory factor 8 (IRF8), is absent or expressed at very low levels in leukemia. In paper II, IRF8 was shown to be a direct target gene of WT1, repressed by WT1 both in human hematopoietic progenitor cells and in leukemic cell lines. Furthermore, a strong …
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Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation
… and/or expression of negative regulators (IRF8, ETS-1). In addition, we found that estrogen epigenetically regulates IL-17 induction by miRNAs (miR-326 and miR-223). We also found that majority of IL-17 positive cells are CD8⁺ suggesting that estrogen-mediated IL-17 induction is …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… analysis revealed that Brd4 co-localized with Irf8 and Pu.1 at the promoter regions of Naips, activating their transcriptions. Moreover, myeloid lineage-specific Brd4 conditional-knockout (Brd4-CKO) mice were more sensitive to S. Typhimurium infection with the significantly enhanced bacterial …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… are bound by ZFP36L1 and transcription factors IRF8 and Notch-1, and multiple cytokines and chemokines, including IFN-γ, TNF-α, IL-2 and CCL3/4. In addition, I describe a novel reporter mouse model of ZFP36L1 with an N-terminal fusion of a red-fluorescent protein expressed from the endogenous …
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Investigating the role of macrophages in larval zebrafish heart regeneration
… the site of injury. I next used macrophage-less irf8-/- larvae and metronidazole-nitroreductase macrophage ablation to test the requirement for macrophages for several important regenerative processes. My data showed macrophages to be required for wound debridement and cardiomyocyte proliferation …
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The ontogeny and function of intestinal dendritic cells
… of CD103+CD11b- cDC depends on the TFs Id2, IRF8 and BatF3, the TF requirements for CD103+CD11b+ were not known. Using a mouse model that selectively depletes the TF IRF4 selectively in CD11c+ cells, we show that, similar to splenic/lymph node CD11b+ cDCs, intestinal CD103+CD11b+ cDCs depend …
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Regulation of T cell effector functions in the intestinal mucosa
… small intestinal mucosa. Further, we found that IRF8, but not IRF4, expression by intestinal dendritic cells (DCs) was critical for the development of the FoxP3+ subset in steady state but not the inflammatory setting. Collectively these findings broaden our understanding of the mechanisms …