Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"IRF5"”.
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Regulatory Mechanisms in Innate Immunity
… cytokines. As an important transcription factor, IRF5 was known to be essential for the host cytokine production in response to various ligands and SNPs in IRF5 have been closely related to autoimmune diseases. However, the mechanism by which IRF5 is activated is not well understood. In the first …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… significant reductions in the proinflammatory IRF5 and increases in the anti-¿¿inflammatory IRF4 in the APPPS1;IRAK4 KI animals. These changes were correlated with maintenance of A¿¿ clearance pathways and improvements in olfactory behavioral tests. Together, our results demonstrate that IRAK4 …
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Dynamic Programming of Innate Immunity in Health and Disease
… adapted by super-low dose LPS, mediated through IRF5. For the in vivo system, we have employed both acute and chronic models of inflammation. For the chronic model, we have tested the effects of super-low dose LPS on monocyte polarization in vivo, as well as its contribution to the pathogenesis …
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
… to activate the transcription factors NF-kB and IRF5 and the protein kinase Tpl2, but how IKKβ itself is activated in vivo is still unclear. It was found to require phosphorylation by one or more ‘upstream’ protein kinases in some reports, but by autophosphorylation in others. In the first part …