Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"IRF4"”.
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Exploring the role of IRF4 in the sensitivity of mantle cell lymphoma cells to Bruton's Tyrosine Kinase inhibitors
… develops previous work by the group identifying IRF4 as a central mediator of resistance to BTK inhibitors in MCL; the thesis aims to understand how resistance develops and to identify mechanisms to prevent or overcome BTKi resistance in MCL.<br/><br/>Methods: Cell models of BTKi sensitivity or …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… separated based on levels of IL-10 secretion, IRF4 expression segregates into the subset of Th2 cells expressing high levels of IL-10. To investigate the role of IRF4 in cytokine heterogeneity, Th2 cells were infected with retrovirus expressing IRF4. The cells overexpressing IRF4 secreted …
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Signals for B cell activation in antibody response
… affinity of antibodies produced outside the GC. IRF4 is essential for the plasma cell differentiation and Ig class switch. IRF4 mRNA and protein rapidly upregulate within one hour after naive B cells get stimulation with NP-Ficoll in QM×C57BL/6 mice, and then activated B blasts expressing …
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Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
… and CD8 T cells. Transcription factors IRF8 and IRF4, in cDC1s and cDC2s respectively, mediate this suppression of inflammasome activation by limiting the expression of inflammasome-associated genes. Additionally, overexpression of either of IRF4 or IRF8 is sufficient to inhibit inflammasome …
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The ontogeny and function of intestinal dendritic cells
… a mouse model that selectively depletes the TF IRF4 selectively in CD11c+ cells, we show that, similar to splenic/lymph node CD11b+ cDCs, intestinal CD103+CD11b+ cDCs depend on IRF4 for their development. Further, we demonstrate that IRF4-dependent cDCs play a key role in the generation and …
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Early divergent B cell differentiation during antibody responses
… independent type II responses. The protein IRF4, which is essential for CSR and plasmablast differentiation, is expressed in all responding cells immediately after immunization and selectively upregulated to high levels in plasmablasts. A hierarchy of gene expression was identified as B …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
… suppression of DC-promoting transcription factor Irf4. Genetic inhibition of RA production by tumor cells or pharmacologic inhibition of RA signaling within the TME increased stimulatory monocyte-derived cells, enhanced T cell-dependent anti-tumor immunity and demonstrated striking synergy with …
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Genetic alterations defining human primary melanoma and mechanisms of immune evasion
… mediated by Interferon Regulatory Factor 4 (IRF4). I then begin to experimentally validate and explore the biological pathway by which IRF4 may function in the context of melanoma. Checkpoint inhibitors have revolutionised melanoma care, yet only a minority of patients respond to these …
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Maternal β-Glucosylceramides Alter Neonate Hematopoiesis and Lung Microbiota
… precursors. This causes the expansion of IRF4+ dendritic cells, which are known to induce allergy. Furthermore, we show that the lung microbiota is altered in mouse pups born to allergic mothers and that this dysbiotic microbiota is sufficient to induce allergen hyperresponsiveness in …
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Onkogenomische Aspekte Zytokin-assoziierter Signaltransduktion
… Genen sind vor allem der Transkriptionsfaktor IRF4, die IL-13-Rezeptoruntereinheit IL13Ra1, die Rezeptortyrosinkinase EphB1 und die Proteinphosphatase PTPRK zu erwähnen. Diese Faktoren könnten mit dem malignen Phänotyp der Zellen verbunden sein und neue Ziele im Sinne einer Therapieoptimierung …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… Th9 development include STATs, PU.1, BATF, and IRF4. In this study, we identify ETV5 as a factor that promotes IL-9 and IL-10 production by binding to cis-acting regulatory elements in the respective genes. At the Il9 gene, ETV5 cooperates with PU.1 in regulating gene expression. At the Il10 …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… IRF5 and increases in the anti-¿¿inflammatory IRF4 in the APPPS1;IRAK4 KI animals. These changes were correlated with maintenance of A¿¿ clearance pathways and improvements in olfactory behavioral tests. Together, our results demonstrate that IRAK4 activation in later stages of disease impairs …
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
… the GRNs with CRISPR knock-outs, I showed that IRF4 was necessary for acquiring both GC and plasma cell fates. Further, knock-out of the GRNs governing the plasma cell fate rewired the memory B cell transcriptome and induced the emergence of GC cells. Finally, I studied the clonal control of …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… (IKZF3) and Interferon regulatory factor-4 (IRF4), a significant downregulation of protein levels was observed after treating the MM cell lines with sub-cytotoxic concentrations of ZnDDC (2-5 μM). After exposure to low concentration of ZnDDC, levels of both IL-2 mRNA and protein were …
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The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
… other associated Treg suppressive markers (i.e. IRF4 and Helios) during the course of these helminth infections. Taken together, our findings supported a role for IL-4Rα signaling in the positive regulation of Foxp3+ Tregs function and thus, the suppression of inflammatory responses during …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
… amplification of several oncogenes including IRF4, which has previously been implicated in ALCL pathogenesis. Next, I tested the second generation ALK inhibitor brigatinib, demonstrating the utility of our models as a platform to test targeted therapies. Brigatinib was highly effective in the …
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Regulation of T cell effector functions in the intestinal mucosa
… mucosa. Further, we found that IRF8, but not IRF4, expression by intestinal dendritic cells (DCs) was critical for the development of the FoxP3+ subset in steady state but not the inflammatory setting. Collectively these findings broaden our understanding of the mechanisms regulating CD8+ T …