Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"IRF3"”.
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Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3
… to activate downstream transcription factors IRF3 and NF-kB, which contribute to the induction of IFNb. Despite growing list of components revealed in RIG-I/MAVS/IRF3 pathway, molecular mechanism by which MAVS activates IRF3 upon viral infection has remained largely unclear. In current study, …
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Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction
… of the parallel interferon regulatory factor-3 (IRF3) signaling cascade in any facet of this process. Several key findings suggest that IRFs contribute to both cell growth and apoptosis, thus providing an appealing, and novel target for interrogation. In this thesis I describe how IRF3 …
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THE ROLE OF INTERFERON REGULATORY FACTORS IN REGULATING THE EXPRESSION OF NKG2D LIGANDS
… kinase TBK1 and its phosphorylation target IRF3. The activation of IRF3 in response to DNA damage was evidenced by its phosphorylation and nuclear translocation. TBK1 is upstream of IRF3 and similarly, its phosphorylation was observed during DNA damage. The pharmacological inhibition or …
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REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5
… TWO PROTEINS, INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES IN OBESITY-RELATED METABOLIC DISEASES. WE FOUND THAT IRF3 IS A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE DEVELOPMENT OF OBESITY AND TYPE 2 …
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LUBAC is required for the RIG-I mediated antiviral response
… The resulting signalling platform activates both IRF3 and NF-κB, resulting in induction of an antiviral response. Early sensing of infection is essential for effective clearance of virus infection with minimal damage to the host. In this study we set out to understand the contribution of the …
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Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
… pathways culminating in the activation of IRF3 and subsequent type I interferon (IFN) antiviral response. This intrinsic protective mechanism is orchestrated by a host of positive and negative regulators, which collectively govern the magnitude and duration of antiviral signaling. SRMS …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… factors including IFN regulatory factor 3 (IRF3). Interestingly, we found evidence that the same defense mechanisms are implicated in protecting organisms from cancer. We discovered that B-cell lymphomas and many tumor cell lines of various origin constitutively express cytosolic DNA as a …
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Probing the Mechanisms Underlying the Regulatory Effects of Cactin in Innate Immune Signalling Pathways
… also negatively regulates the activation of IRF3 and IRF7 and suppression of endogenous Cactin augments Poly(I:C)-mediated IFNβ induction. Cactin localises to the nucleus by virtue of two nuclear localisation sequences (NLS)s and its nuclear expression is essential for manifesting its …
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Characterization of The Roles of Carma3 and Bcl10 In Virus-Triggered Rig-I/Mavs Signaling Pathway
… to recruit TBK1and IKK complex to activate IRF3 and NF-κB, respectively. Herein, we revealed the important roles of CARMA3 and BCL10 in RIG-I/MAVS signaling pathway for the first time. CARMA3 or BCL10 deficient cells exhibited partially defective NF-κB activation but hyperactivation of …
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Host cell signaling in response to RSV infection
… B (NF-kappa B) and interferon response factor 3 (IRF3) to the nucleus at the early phase of viral infection. In contrast, siRNA-mediated TLR3 knockdown did not affect RSV-induced NF-kappa B binding to DNA but block the activating phosphorylation of NF-kappa B /RelA at serine residue …
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Innate sensing and regulation during enteric caliciviruses infections
… we show that MED23 interacts with IRF3, and is required for recruitment of RNA Polymerase II to promoters of IRF3-dependent genes. Taken together, our data indicate that MED23 plays a central role in antiviral responses by coupling IRF3 activation and RNA Pol II recruitment.
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… IFNb expression, interferon regulatory factor 3 (IRF3). Mutational analysis revealed that the CLD within the C-terminus of cFLIPL is responsible for inhibiting IRF3-CBP-DNA interactions. Further, when cFLIPL was knocked down in various tumor cell lines, levels of tumor protective interferon …
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The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein
… virus, induced the synthesis of IFN-β mRNA. IRF3, a key transcription factor for transcription of the IFN-β gene, was activated in mutant virusinfected cells, but not in wild-type virus-infected cells. Transfection assays implicated the activation of the TBK1 kinase as the step in IRF3 …
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Understanding Host Antiviral Signaling Pathways
… B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors regulate the synthesis of protective cytokines including type I interferons. The first detection system includes members of the toll-like receptor family (TLR3, TLR7, TLR8 …
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
… by suppressing interferon regulatory factor 3 (IRF3) dependent innate antiviral defenses. IRF3 plays a key role in viral-induced type I IFN induction pathway. Thus, viruses are well-known to evade the establishment of an antiviral state by regulating the activation of IRF3. However, functional …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
… targets interferon regulatory factor 3 (IRF3), a transcription factor essential for regulating type I interferon (IFN) expression. These findings also demonstrate that protective effects of R(+)WIN55,212-2 in EAE mice exist, as evidenced by reduced clinical scores, demyelination and …
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Investigations into novel signalling pathways in the response to viral and bacterial infections
… TLR7 signalling was shown to activate IRF3 and NFκB in murine bone marrow derived macrophages. However, while TLR7 mediated IRF3 activation was TRAM dependent, NFκB activation was not. TRAM was also shown to mediate signalling via a physiological activator of TLR7, human rhinovirus 16 …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
… While NSP1 was known to mediate degradation of IRF3 to antagonise the host immune response, the differences observed between Caco-2 and A549 cells were not due to IRF3 degradation. This study highlights the distinct transcriptional profile following virus replication; Caco-2 cells infected with …
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Unravelling the anti-inflammatory mechanisms of dietary fatty acids
… TLR4 downstream transcription factors NF-κB and IRF3, while n-3 PUFA, DHA and EPA solely inhibited NF-κB. Further investigation revealed that PUFA selectively regulate the expression of TLR4 and its associated molecule CD14 in response to LPS, but had no effect on LPS binding to TLR4. The exact …
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Identification of a gap junction communication pathway critical in innate immunity
… (NFKB) and Interferon regulatory factor 3 (IRF3). Stimulation of NFKB-GFP reporters resulted in a spatially homogeneous pattern of activation, found to be largely mediated by paracrine action of the pro-inflammatory cytokine TNFa. In contrast, the activation of IRF3 was spatially …
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