Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"IRF1"”.
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The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… factor expression and function, specifically of IRF1 and ATF3 in corneal epithelial cells to elucidate the transcriptional mechanisms underlying the protective function of flagellin on the cornea. </p> <p>Initially we used Superarray to screen for transcription factors and identified Interferon …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… CsA induces interferon regulatory factor-1 (IRF1)-dependent antiviral gene expression. While CsA does not increase IRF1 levels in Huh7 cells, it enhances IRF1 protein levels in A549 cells, which may contribute to its inhibitory effect against DENV-2. CsA inhibits cyclophilins, whose chaperone …
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MANIPULATING CELL STATES FOR LEUKAEMIA DIFFERENTIATION THERAPY USING NETWORK PHARMACOLOGY
… of MOGRIFY-identified TFs, specifically MYC and IRF1, also leads to co-operative induction of differentiation in APL cells. We also outline potential mechanisms by which MYC down-regulates IRF1 expression in NB4 cells. We anticipate that MOGRIFY could be used to discover TF-based differentiation …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… III IFN response. PEDV specifically inhibited IRF1 nuclear translocation. Peroxisomes are the innate antiviral signaling platforms for activation of IRF1-mediated IFN-λ production, and they were found to decrease in number in PEDV-infected cells. PEDV nsp1 blocked the nuclear translocation of …
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New Roles for Mitochondria in Shaping Antiviral and Stress Responses
… selective protein degradation of the ISG IRF1. Notably, glucose-rich conditions, relative to galactose, amplify IFN-γ efficacy to restrict herpes- and poxvirus infection. In contrast, cells in galactose media display no differences in herpes- and poxvirus replication between untreated and …
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Analysis of B lymphocyte activation and differentiation by expression profiling
… are T1 and T2 B cells. We also could show that IRF1 is downregulated upon BCR cross-linking in SLP65-/- B cells. In addition, we found that the SLP65-/- B cells express low levels of TACI and the expression levels of TACI is drastically reduced in EGRxSLP65-/- B cells. Due to the block at the …
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The role of miRNA-486-5p in hair growth and the hair follicle immune privilege
… suppression of IP by up-regulating HLA class 1, IRF1, ICAM1 and CADM1 expression of which CADM1 was confirmed to be a direct target of miR-486- 5p. Transcriptome profiling of primary human epidermal keratinocytes overexpressing miR-486-5p revealed damping the signalling pathways associated with …
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Computational and experimental methods for CRISPR-based saturation mutagenesis screens
… oncogene to identify drug resistant variants and IRF1 untranslated region (UTR) to map non-coding regulatory elements involved in transcriptional initiation.
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Unraveling the molecular mechanisms of the class II transactivator, CIITA in skeletal muscle
… is intact in these cells, but pSTAT1 and IRF1 do not bind to the CIITA PIV promoter. The CIITA promoter is not hypermethylated in RD (ERMS) cells, but shows a modestly enhanced methylation status in SJRH30 (ARMS) cells. We have also observed that histone acetylation, which normally …