Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"IRF-3"”.
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
… by suppressing interferon regulatory factor 3 (IRF3) dependent innate antiviral defenses. IRF3 plays a key role in viral-induced type I IFN induction pathway. Thus, viruses are well-known to evade the establishment of an antiviral state by regulating the activation of IRF3. However, functional …
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The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection
… infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or the loss of IRF-3 would be predicted to render early recognition pathways inoperative and thus impact viral infection. However, previous results had produced contradictory …
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Untersuchung Influenza Virus-induzierter Signalprozesse und deren Bedeutung in der Wirtszell-Abwehr
… für die Transkriptionsfaktoren AP-1, NF-kB und IRF-3 in seiner Promotorsequenz besitzt. In früheren Arbeiten konnten wir zeigen, dass die Influenza Virus-induzierte AP-1 abhängige Genexpression über den JNK/SAPK-Signalweg erfolgt (Ehrhardt, 1999; Ludwig et al., 2001). Unter den, an DNA Elemente …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and IFN-stimulated genes required for …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and IFN-stimulated genes required for …
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Coronavirus Replicase Proteins: Multifunctional Mediators of Replication and Innate Immunity Evasion
… shown to inhibit the induction of IFN-β-, IRF-3- and NF-κB-luciferase reporters. In contrast to MHV, the PLPs from HCoV-NL63 (PLP2) and SARS-CoV (PLpro) were able to inhibit type I IFN induction independently of catalytic activity albeit to a lesser degree than wildtype. Further …
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Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance
… the activation of interferon regulatory factor (IRF)-3 by virus infection or HCV dsRNA transfection. We found that a mutation in the caspase recruitment domain (CARD) of the DExH/D-box helicase protein RIG-I, a component of the TLR3-independent intracellular dsRNA-responsive IRF-3 activation …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
… the latent downstream transcription factors IRF-3 and NF-kappaB. These transcription factors bind to the promoter region of effector genes including IFN-beta, producing an antiviral amplification loop within and around the infected cell. This response is critical for immunity to infection. …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… of these cytokines through the NF-κΒ and IRF-3 transcription factors. TNF-α is a critical initiator of the pro-inflammatory response during infection. Previous studies found that MC159 is a potent inhibitor of the TNF-α pathway by blocking activation of the NF-κB pro-inflammatory …
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A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism
… of interferon genes) to induce expression of an IRF-3 dependent luciferase reporter. Furthermore, using immunofluorescence I demonstrated that HCoV-NL63 non-structural protein 3 (viral protein in which PLP2 resides) co-localizes with STING suggesting that HCoV-NL63 PLP2 may be targeting STING …
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Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape
… activation of interferon regulatory factor 3 (IRF-3). As a result, BRSV is able to block the establishment of a cellular antiviral state. The characterization of interactions between virus (NS proteins) and the host cell (IFN system) will have important implications in the development of …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… of interferon regulatory transcription factors IRF3, IRF7 and NF-κB. These transcription factors mediate inflammatory process to clear virus infection. Viruses can evade host antiviral defenses by using several strategies. SARS coronavirus (SARS-CoV), a highly contagious causative agent of …
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Hepatitis C Virus NS5A Targets the Nucleosome Assembly Protein NAP1L1 to Control the Interferon Response
… and specifically modulates TBK1/IKKε mediated IRF-3 phosphorylation and NF-κB levels. Hence, both the TLR3 and RIG-I/MDA5 pathways are affected by NAP1L1 depletion. I could further demonstrate that NAP1L1 controls the basal transcription of genes involved in the immune pathway and that it …
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Untersuchung der Typ I Interferon-Signaltransduktion in HPV-Onkogen immortalisierten Keratinozyten
… IFN-abhängiger Gene einher, wie z.B. PKR, MxA, IRF-7 und p48 (IRF-9). Untersuchungen der IFN-Signaltransduktion zeigten, daß E6 auf die �Interferon-Regulatory-Factor� (IRF)-3-Aktivierung und Dimerisierung sowie die nachfolgende Induktion des IFN--Gens keinen negativen Einfluß ausübt. Dies steht …
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Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model
… on viral RNA replication, utilising TBK-1 and IRF-3 signalling to induce an antiviral state and viral killing. This late response also seems to play a role in resolving the ‘early’ responses to prevent the cytokine storm associated with severe uncontrolled response. The complexity and varied …
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Acute pancreatitis, from local defense to remote organ injury
Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung …