Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"IRF-1"”.
-
Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology
Interferon regulatory factor 1 (IRF-1), the founding member of IRF family, is a nuclear transcription factor first described as a transcription factor that binds to the upstream region of interferon induced genes following viral infection. In addition, IRF-1 has been reported to be involved in cell …
-
A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… CHRY treatment also led to upregulation of IRF-1 mRNA and protein which was dependent on Stat1. Further analyses demonstrated that topical treatment with CHRY but not TPA upregulated interferon-gamma (IFNg) mRNA in the epidermis and that the induction of both IRF-1 and uStat1 was dependent …
-
Untersuchung der Typ I Interferon-Signaltransduktion in HPV-Onkogen immortalisierten Keratinozyten
… IFN-abhängiger Gene einher, wie z.B. PKR, MxA, IRF-7 und p48 (IRF-9). Untersuchungen der IFN-Signaltransduktion zeigten, daß E6 auf die �Interferon-Regulatory-Factor� (IRF)-3-Aktivierung und Dimerisierung sowie die nachfolgende Induktion des IFN--Gens keinen negativen Einfluß ausübt. Dies steht …
-
The regulation of human airway epithelial expression of viperin by human rhinovirus
… DNA binding of interferon regulatory factor 1 (IRF-1). We showed that CSE inhibits HRV-induced viperin mRNA and protein expression but that CSE does not alter HRV-induced promoter activation, raising the possibility that CSE-mediated inhibition of viperin induction is due to epigenetic …
-
Identification and Characterization of Control Elements within the Murine CD4 Gene
… and AP-1 for the 5' intronic enhancer, and PU.1, IRF-1, and GATA-1 for the 3' intronic enhancer. Among them, Elf-1 and PU.1, members of the Ets protein family, and AP-1 have been implicated in the regulation of T cell-specific gene expression. An intronic promoter is located in the 138 bp fragment …
-
The regulation and function of viperin during rhinovirus infection
… protein 5 (MDA5), or IL-29 signalling, promotes IRF-1 mediated viperin transcription. Viperin then establishes a protein-protein interaction with MDA5 which results in enhanced MDA5 stability in RV infected cells. This leads to enhanced signalling through MDA5, as measured by increased CXCL10 …
-
Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
"Cholesterols are enriched in the brain and can be oxidized to oxysterols by spontaneous or enzyme-mediated processes. Oxysterols are transport forms of cholesterols across cell membranes and the blood-brain barrier. Here, to elucidate the roles of oxysterols in brain inflammation, I treated …
-
The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… factor expression and function, specifically of IRF1 and ATF3 in corneal epithelial cells to elucidate the transcriptional mechanisms underlying the protective function of flagellin on the cornea. </p> <p>Initially we used Superarray to screen for transcription factors and identified Interferon …
-
Interference of Toxoplasma gondii with IFN-γ-regulated gene expression of its host cell
… Expression des interferon regulatory factor-1 (IRF-1). Des weiteren verringern beide, lebende T. gondii und Parasitenlysat, die transkriptionelle Aktivität des CIITA Promotor IV, während nur lebende T. gondii dazu fähig sind einen minimalen GAS enthaltenden Promotor zu beeinflussen, wie durch …