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Showing 1 to 20 of 64 for “"IRF"”.

  1. Improvement of tunable diode laser spectrometer IRF

    Dinh, Vincent V

    sjsu Repository record

  2. Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology

    Al Samman, Khaldoon Mohammed A, Alsamman, KhaldoonThe University of Edinburgh2012

    Interferon regulatory factor 1 (IRF-1), the founding member of IRF family, is a nuclear transcription factor first described as a transcription factor that binds to the upstream region of interferon induced genes following viral infection. In addition, IRF-1 has been reported to be involved in cell …

    edinburgh Repository record

  3. Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation

    Jiang, Xin Ru, <p>0000-0002-8938-8886</p>2025

    … was associated with upregulation of the IRF family of transcription factors through epigenetic reprogramming. Overall, this study provides critical insights into the mechanisms driving sustained NK cell cytotoxicity in response to oncolytic viral infection of tumor cells and highlights …

    uthsc Repository record

  4. Integracja szlaków sygnalizacyjnych interferonu gamma i receptora TLR4 w procesie zapalnym naczyń krwionośnych, warunkowana czynnikami transkrypcyjnymi STAT1 i IRF

    Chmielewski, Stefan2014

    amu-pl

  5. Charakterisierung des patho-physiologischen Stellenwertes des Transkriptionsfaktors Interferon-Regulator-Faktor-1 (IRF-1) bei der Coxsackievirus-Infektion der Maus

    Michaelis, CorneliaLudwig-Maximilians-Universität

    lmu-germany Repository record

  6. The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection

    Menachery, Vineet2010

    … infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or the loss of IRF-3 would be predicted to render early recognition pathways inoperative and thus impact viral infection. However, previous results had produced contradictory …

    wustl Repository record

  7. Untersuchung Influenza Virus-induzierter Signalprozesse und deren Bedeutung in der Wirtszell-Abwehr

    Ehrhardt, ChristinaUniversität Würzburg

    … für die Transkriptionsfaktoren AP-1, NF-kB und IRF-3 in seiner Promotorsequenz besitzt. In früheren Arbeiten konnten wir zeigen, dass die Influenza Virus-induzierte AP-1 abhängige Genexpression über den JNK/SAPK-Signalweg erfolgt (Ehrhardt, 1999; Ludwig et al., 2001). Unter den, an DNA Elemente …

    wurz-thes Repository record

  8. Comparison of Luteolysis and Timed Artificial Insemination Pregnancy Rates after Administration of PGF2a in the Muscle or the Ischiorectal Fossa in Cattle

    Holland, Sarah C.Virginia Tech2015

    … quality assurance is the ischiorectal fossa (IRF). The objective of this study was to determine whether administration of PGF2α in the IRF results in a similar physiologic response to administration of PGF2α given IM. Yearling angus-cross heifers (n=112) were blocked by weight and randomly …

    vt Repository record

  9. Effect of Obesity on Outcomes following Total Hip/Total Knee Arthroplasty among Medicare Beneficiaries with Osteoarthritis

    Kulkarni, KshitijaThe University of Texas Medical Branch at Galveston2021

    … stay (LOS) at inpatient rehabilitation facility (IRF), and discharge destination following IRF stay, and on long-term outcomes following discharge from the IRF including 30-day hospital readmissions, the reasons for readmission and mortality within the duration of the study period. The study …

    utmb Repository record

  10. Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus

    Lester, Sandra Nicole2020

    … by suppressing interferon regulatory factor 3 (IRF3) dependent innate antiviral defenses. IRF3 plays a key role in viral-induced type I IFN induction pathway. Thus, viruses are well-known to evade the establishment of an antiviral state by regulating the activation of IRF3. However, functional …

    tenn-hsc Repository record

  11. Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease

    Foy, Eileen2007

    … protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and IFN-stimulated genes required for …

    tdl Repository record

  12. Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease

    Foy, Eileen2010

    … protein as an interferon regulatory factor 3 (IRF-3) and NF-<small>K</small>B antagonist and further mapped this activity to the NS3/4A serine protease domain. HCV antagonism of IRF-3 and NF- <small>K</small>B prevents the expression of interferon (IFN) and IFN-stimulated genes required for …

    utswmed Repository record

  13. Untersuchung der Typ I Interferon-Signaltransduktion in HPV-Onkogen immortalisierten Keratinozyten

    Ritter, Tina MariaUniversität Heidelberg

    … IFN-abhängiger Gene einher, wie z.B. PKR, MxA, IRF-7 und p48 (IRF-9). Untersuchungen der IFN-Signaltransduktion zeigten, daß E6 auf die �Interferon-Regulatory-Factor� (IRF)-3-Aktivierung und Dimerisierung sowie die nachfolgende Induktion des IFN--Gens keinen negativen Einfluß ausübt. Dies steht …

    heid-diss Repository record

  14. Examination of discharge settings and readmission rates following hospitalization for total knee arthroplasty

    Welsh, Rodney LaineThe University of Texas Medical Branch at Galveston2021

    … to inpatient rehabilitation facilities (IRFs). The other two common post-acute settings include skilled nursing facilities (SNFs) and home- and community-based rehabilitation. We used Medicare data from beneficiaries who received TKA to examine 1) time trends in hospital discharge …

    utmb Repository record

  15. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Svensson, EmelieDivision of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University2006

    … downregulated interferon regulatory factor 8 (IRF-8). Using a bacterial II hybrid assay, we also identified cofilin 1 as a novel protein partner of WT1. Our data also indicate that BCR/ABL1 induce expression of the WT1 gene via the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway in …

    lund Repository record

  16. Timing performance of superconducting nanowire single-photon detectors

    Najafi, FarazMassachusetts Institute of Technology2015

    … (also called instrument response function IRF) of these detectors as a function of bias current, nanowire width and wavelength. The study of the IRF yielded several unexpected results, among them a wavelength-dependent exponential tail of the IRF and a discrepancy between experimental …

    mit Repository record

  17. An Integrated Real options Framework for model-based identification and valuation of options under uncertainty

    Mikaelian, TsolineMassachusetts Institute of Technology2009

    … introduces an Integrated Real options Framework (IRF) that supports holistic decision making under uncertainty by considering a spectrum of real options across an enterprise. In the context of the IRF, enterprise architecture is described in terms of eight views and their dependencies and modeled …

    mit Repository record

  18. Coronavirus Replicase Proteins: Multifunctional Mediators of Replication and Innate Immunity Evasion

    Clementz, Mark Anthony2016

    … shown to inhibit the induction of IFN-&beta;-, IRF-3- and NF-&kappa;B-luciferase reporters. In contrast to MHV, the PLPs from HCoV-NL63 (PLP2) and SARS-CoV (PLpro) were able to inhibit type I IFN induction independently of catalytic activity albeit to a lesser degree than wildtype. Further …

    loyola-thes Repository record

  19. Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance

    Sumpter, Rhea Myers, Jr.2010

    … the activation of interferon regulatory factor (IRF)-3 by virus infection or HCV dsRNA transfection. We found that a mutation in the caspase recruitment domain (CARD) of the DExH/D-box helicase protein RIG-I, a component of the TLR3-independent intracellular dsRNA-responsive IRF-3 activation …

    utswmed Repository record

  20. A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis

    Bozeman, Ronald2013

    … CHRY treatment also led to upregulation of IRF-1 mRNA and protein which was dependent on Stat1. Further analyses demonstrated that topical treatment with CHRY but not TPA upregulated interferon-gamma (IFNg) mRNA in the epidermis and that the induction of both IRF-1 and uStat1 was dependent …

    uthsc Repository record

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