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Showing 1 to 20 of 52 for “"IRES"”.
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Mechanisms of Regulation of Tau Ires Mediated Translation
… by utilizing sequences in their 5’ UTR called IRES. It was previously shown that the 5’ UTR of the tau mRNA contains an IRES. In this study I show that IRES dependent translation of tau IRES is regulated at multiple levels in order to regulate the expression of the tau protein.</p> <p>Tau …
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Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C
… Το 5' UTR του HCV περιέχει μια περιοχή IRES απο την οποία γινεται η έναρξη της cap ανεξάρτητης μετάφρασης του ιικού RNA. Η HCV IRES εξαρτώμενη μετάφραση του ORF παράγει μια ενιαία πρόδρομη πολυπρωτεΐνη που μεσω μετα-μεταφραστικής τροποποίησης από κυτταρικές και ιικές πρωτεάσες, οδηγεί …
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Investigations into the role of RNA modification in the function of the c-Myc IRES
… survival, and internal ribosome entry segments (IRES) have been shown to recruit the mRNAs to ribosomes directly in these conditions. It is known that the majority of cellular IRESs, unlike viral IRES, require a “nuclear event” before they are active the cytoplasm and recent data have shown that …
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Conservation of Translation Initiation Between Prokaryotes and Eukaryotes
… al. (2015) reported that the eukaryotic PSIV IGR IRES can initiate prokaryotic translation and effectively circumvent domain-specific divergences. This novel discovery led us to investigate whether this IRES is unique in its ability to initiate prokaryotic translation and attempt to elucidate any …
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Analysis of single event transients in arbitrary waveforms using statistical window analysis
… the Ionizing Radiation Effects Spectroscopy (IRES) technique to enhance the measurement of transient anomalies within arbitrary waveforms. The IRES filter convolves time data with a sliding window consisting of a moment-generating function. The resulting time-dependent statistical moments are …
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Differential Regulation of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex to rc2 Modulates Aurora A Kinase Expression
… of the cap to internal ribosomal entry site (IRES). IRESs are found in certain classes of viruses and a subset of eukaryotic mRNAs. IRES dependent translation is thought to occur during times when the cap is down regulated such as during stress or cell proliferation.</p> <p>Previously we found …
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Ionizing radiation effects spectroscopy
… termed ionizing radiation effects spectroscopy (IRES). IRES identifies radiation effects based on statistical time-frequency analyses of native waveform behavior, thus having a minimal impact on operating performance. The resulting measures are used to identify parametric shifts as well as …
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Human La Function in Expression of Coding Transcripts
… from the internal ribosome entry sites (IRESs) of several cellular and viral coding RNAs. In this study, we investigated the molecular mechanisms by which La interacts with coding transcripts. We show that in addition to a sequence specific UUU-3'OH binding mode, human La exhibits both a …
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Targeting transcriptional and translational mechanisms to enhance utrophin A expression as a therapy for Duchenne muscular dystrophy
… is enhanced via Internal Ribosome Entry Site (IRES)-mediated translation in response to skeletal-muscle regeneration and glucocorticoid treatment. Using transgenic reporter mice, we found that IRES-mediated translation of utrophin A occurs exclusively in skeletal muscle fibers and no other …
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The Role of Secondary and Tertiary Structure in the Cap-Independent Translation of FGF-9 and HIF-1-alpha
… as either internal-ribosome-entry-site (IRES)-like, where the ribosome is recruited at or near the RNA start codon, or cap-independent-translational-enhancer (CITE)-like, where the 5’ UTR must have an unpaired, accessible 5’ end for successful ribosomal recruitment. IRES-like and …
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Structural Insights into Noncanonical Mechanisms of Translation
… cis-acting internal-ribosome-entry sites (IRESs) within their genomes that direct end-independent initiation. The IRES of hepatitis-C virus (HCV), for example, interacts directly with the mammalian ribosome and functionally replaces many of the canonical initiation factors. However, the …
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Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
… (HRVs) utilize Internal Ribosome Entry Sites (IRES) to drive viral protein synthesis. IRESs are specialized RNA elements present within the 5’ UTR of mRNAs that recruit ribosomes independently of the 5’ m7G cap structure. hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1), a multifunctional …
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Assessing and understanding the generation and function of RNA decay intermediates in non-insect borne flaviviruses
… the poliovirus internal ribosomal entry site (IRES) element. We provide evidence that the stalling of XRN1 in the 5' UTR of BVDV is dependent on both the presence of the entire IRES structure and the presence of a stem loop 5' to the IRES element through the analysis of a series of truncations. …
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The Multifunctional Capsid Gene of Hepatitis C Virus
… proteins were translated using a heterologous IRES. This data suggests that these RNA structures are important for translation from the HCV IRES and that the defective translation exhibited by the SLVI mutants contributed to their impaired replication. Thus, RNA structures within the capsid …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… L , believably at Internal Ribosome Entry Sites (IRES) in the mRNAs 5‘ Untranslated Regions (UTR). The hnRNP A1-bound mRNAs are then shuttled to the cytoplasm where they are translated in a 5‘ cap-independent manner following ribosomal recruitment by the IRES structures. Insight into how these …
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Investigation of Age Related Differences in the Rewiring of P2-Olfactory Receptor Neurons
… glomeruli in the olfactory bulb. In the P2 IRES tau-lacZ mouse, the P2 ORN subtype has been previously mapped to two glomeruli, using X-gal staining. To determine if age affects ORN regeneration, left olfactory nerve transections were performed on P2 mice from immature (five-weeks old) and …
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Translation of Partially Decayed Messenger RNAs in Yeast
… site from the cricket paralysis virus (CrPV IRES) to allow for cap-independent translation of the decay-protected gene, <em>LacZ</em>, encoding the enzyme β-galactosidase. Through the use of primer extension, βgalactosidase assay, and western blots, the results indicate that the …
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Production and Testing of a Novel Live-Attenuated Chikungunya Vaccine
… end, multiple strategies were adapted from the IRES-based vaccine strategy first employed with VEEV vaccine strain, TC-83. The first strategy, CHIKV/IRESv1, was highly stable during cell culture passages in Vero cells, and was unable to replicate in mosquitoes. The vaccine was then tested for …
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Structural Basis For Poliovirus Cloverleaf-Mediated Regulation Of Genome Replication
… comprise an internal ribosomal entry sequence (IRES), which makes cap-independent translation possible. Stem-loop I, also known as the cloverleaf, serves as a switch to shut off translation, and promote negative strand RNA synthesis. The cloverleaf has previously been shown to form a …
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Mechanism of transmissible gastroenteritis virus nsp1-mediated translation inhibition
… as well as certain internal ribosome entry site (IRES)- containing mRNAs, in HeLa S10 extract but not in rabbit reticulocyte lysate or wheat germ extract. In this dissertation the mechanism of TGEV nsp1-mediated translation inhibition is further elucidated. Immunofluorescence analysis showed that …
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