Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"IRE1"”.
-
Ire1 regulates cyp11a1 transcription to mediate steroidogenesis in the ovary
… identified inositol-requiring enzyme 1 alpha (IRE1) as a mediator CYP11A1 transcription. IRE1 is an ER stress signal transducer, however an ER stress response is not induced in KGN cells by forskolin treatment. We hypothesize that IRE1 is necessary to mediate CYP11A1 transcription in response …
-
Structure, Mechanism and Chemical Modulation of the Protein Kinase-nuclease Dual-enzyme IRE1
… ancient member of the ER stress transducers, IRE1. ER stress stimulates IRE1 to activate a UPR-dedicated transcription factor called XBP1 in metazoans (or HAC1 in yeast) to bolster the productive capacity of the ER and purge misfolded proteins from the ER. To activate XBP1/HAC1, IRE1 cleaves …
-
Rac1 and IRE1 are Required to Prevent Early Loss of Intestinal Homeostasis in Drosophila melanogaster
<p>No abstract available</p>
-
Regulation of mammalian IRE1α: Co-chaperones and their importance
… to the nucleus by promoting oligomerisation of IRE1, a conserved transmembrane ER stress receptor. Despite significant research, the mechanism of coupling ER stress to IRE1 oligomerisation and activation has remained contested. There are two proposed mechanisms by which IRE1 may sense …
-
Translational Control by the Ribosome-Associated Complex in the Unfolded Protein Response
… by selectively attenuating activation of the IRE1 branch of UPR. When RAC is reduced, Xbp1 mRNA splicing is inhibited upon ER stress. Consistent with this activity, ER stress induces changes in the subcellular distribution of RAC, which coincides with the localization of Xbp1 mRNA. …
-
Stress-signal recognition in the unfolded protein response
… is widely accepted that the key UPR transducer – IRE1 – responds to the unfolded protein burden by dimerisation/oligomerisation-dependent activation, however, the molecular basis of this upstream event in the UPR remains elusive. This thesis provides insight into regulatory mechanisms acting on …
-
P4HB TARGETING HALTS TUMOR GROWTH AND RE-SENSITIZES RESISTANT MELANOMA CELLS TO DABRAFENIB AND TRAMETINIB STANDARD-OF-CARE THERAPY VIA IRE1-⍺ ACTIVATION AND AKT DOWNMODULATION
… of misfolded proteins and activating IRE1⍺ signalling pathway as part of the unfolded proteins response. This resulted in partial cellular death and autophagy induction. Additionally, P4HB knockdown and subsequent ER stress increment reduced AKT phosphorylation, generating a window of …
-
Establishing The Role Of The Pancreatic Transcription Factor Mist1 In Xbp1-Mediated Maintenance Of Pancreatic Acinar Cell Homeostasis
… prompting us to investigate whether loss of the IRE1/XBP1 branch via conditional ablation of XBP1 in mature mouse PACs could be compensated for by the remaining UPR pathways. We show that survival and homeostasis of PACs is wholly dependent on the IRE1/XBP1 axis of the UPR. Specifically, ablation …
-
Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and Its Impact on Proteostasis
… to ER Stress Response (MERSR). During MERSR, the IRE1 branch of UPRER is inhibited, introducing a previously unknown regulatory component of MCSR. Moreover, proteostasis is enhanced through the upregulation of the PERK-eIF2a signaling pathway, increasing phosphorylation of eIF2a and improving the …
-
The unfolded protein response and HLA-B27 misfolding: implications for ankylosing spondylitis
… of BiP and splicing of XBP1, a key step in the IRE1 pathway of the UPR which is increasingly being linked with intestinal inflammation. We also demonstrate that different cell lines respond to different ER stress stimuli in distinct ways. We establish that HT1080 cells inefficiently induce a UPR …
-
Regulation of the unfolded protein response by GADD34 and CReP
… ER-to-nucleus signal kinase 1 (IRE1). PERK activation leads to the phosphorylation of the α-subunit of the translation initiation factor eIF2α on Serine 51 in activating its function. EIF2α phosphorylation leads to up-regulation of GADD34 and GADD34 bind protein phosphatase 1 …
-
The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
… factor 6 (ATF6), inositol-requiring 1 (IRE1) and PKR-like ER localized kinase (PERK). The UPR is largely a cytoprotective response and is thought to contribute to tumor survival in the face of inadequate nutrients and oxygen. Microarray analyses were conducted on Daoy, a human …
-
Identification of a Novel Regulator of ER Stress-Induced Apoptosis
… event during ER stress and the UPR is the Ire1-mediated splicing of unspliced xbp1 (xbp1U) into the potent transcription factor spliced Xbp1 (Xbp1S). If the ER cannot return to homeostasis, the apoptotic program is activated. Programmed cell death (apoptosis) is an evolutionarily conserved, …
-
Studies on the interaction between porcine reproductive and respiratory syndrome virus and its natural host cell
Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, causes a costly global disease of swine. PRRSV infects their alveolar macrophages (AMΦ) resulting in an interstitial pneumonia. The ability of PRRSV to modulate the production of interferon (IFN)a and tumor necrosis factor …