Global ETD Search
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Showing 1 to 3 of 3 for “"IRAKs"”.
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… of the kinase and pseudokinase domains of the IRAKs.<br/><br/>In collaboration with Janssen Pharmaceutica, I performed a high-throughput assay to screen for small molecule binders of the IRAK pseudokinases. I identified and started to characterise twelve small molecules that bind to the IRAK3 …
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The Association Between The Il-1 Pathway
… are IL-1RI, IL-1RAcP, IL-1RA, MYD88, TOLLIP, IRAKs, MEKK1, MEK3, MEK6, JNK, P38, c-JUN, ECSIT, TRAF6, TAB1, TAK1, RKIP, NIK, IKKα, IKKβ, IκBα, and NF-κB.</p> <p>The individual SNP analysis proved to be interesting though inconclusive. There were some borderline significant results, such as …
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
Alzheimer’s disease (AD) is characterized by the deposition of ¿¿-¿¿amyloid into plaques and neurofibrillary tangles in the brain that is accompanied by a robust immune response. Microglia, the tissue macrophages of the brain, detect and respond to deposited amyloid. Their response is coordinated …