Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IRAK4"”.
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THE ROLE OF IL-¿¿1 RECEPTOR-¿¿ASSOCIATED KINASE 4 IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE
… interleukin-¿¿¿1 receptor-¿¿associated kinase 4 (IRAK4), to investigate the role of all TLRs in the microglial response to A¿¿. Using mice where inactive IRAK4 had been knocked into the endogenous IRAK4 (IRAK4 KI) we found that IRAK4 is necessary for microglia to activate proinflammatory MAP …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… or to mice with catalytically inactive IRAK1 or IRAK4 kinases prevented the increase in the monocytes, suggesting that a TLR7-MyD88-IRAK4-IRAK1 pathway not only drives lupus in ABIN1[D485N] mice but also increases the number of patrolling monocytes. Targeting this pathway using an IRAK4 specific …
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Investigating the impact of ageing on the tumour microenvironment and its crosstalk with malignant cells in pancreatic cancer
… the Toll-like receptor signalling cascade and IRAK4 activation in aged mouse models as a potential age-dependent therapeutic vulnerability. Finally, while senolytic therapy failed to show beneficial results, inhibition of IRAK4 significantly and selectively reduced tumour growth in aged mouse …
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… active IRAK family members, IRAK1 and IRAK4, have advanced our understanding of their roles in the TLR/IL-1R signalling pathway. However, there is no structural or mechanistic information about the two IRAK pseudokinases, IRAK2 and IRAK3. For this reason, I focused my research on the …
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The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
… of TLR4 and the downstream effectors IRAK4 and NF-κB in Smad3⁻/⁻-infected colonic tissues. Examination of adaptive immune regulation in this model demonstrated that SMAD3 was necessary for FOXP3 expression in H. hepaticus-infected splenocytes. Loss of SMAD3 resulted in up-regulation of …
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Understanding the Myddosome Complex: An Exploration of How Homotypic Death Domain Interfaces Contribute to Overall Structure.
… al [1], by combining the Death Domains of MyD88, IRAK4 and IRAK2. The complex was shown to form a left-handed helical tower as it assembles in a staggered hexagonal pattern, due to the three characteristic types of homotypic Death Domain (DD:DD) interactions seen in complexes of the Death Domain …