Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IRAK-M"”.
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Identificazione e caratterizzazione di un gene associato all'asma ad insorgenza precoce persistente
… linkage to a portion of 12q13-24. We identified IRAK-M as the gene in the candidate region implicated in early-onset persistent asthma. We defined protective and predisposing haplotypes and replicated associations in an outbred Italian population. Sequence analysis in 100 patients found mutations …
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Negative Regulation of Inflammation: Implications for Inflammatory Bowel Disease and Colitis Associated Cancer
… interleukin receptor associated kinase M (IRAK- M), is explored in detail within the present dissertation. Investigation of IRAK-M in mouse models of colitis, which mimics human IBD, and in mouse models of inflammation-driven tumorigenesis, which models colitis associated cancer, …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… of the inhibitory TLR4 pathway molecules Lyn or IRAK-M resulted in sustained induction of IL-12 by high doses of LPS. By activating CREB, we were able to reduce inflammation in WT BMDM, and saw that this corresponded with increased phosphorylation of CREB. Overall, we are confident that this …
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Molecular and Cellular Mechanisms Responsible for Low-grade Stress and Inflammation Triggered By Super-low Dose Endotoxin
… an Interleukin-1 receptor-associated kinase 1 (IRAK-1) dependent manner. In the second study, the molecular mechanisms governing the role of super-low dose LPS on cellular stress and endosome/lysosome fusion were examined. In the presence of low-dose LPS (50pg/ml), endosomal-lysosomal fusion is …
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… up-regulation of negative regulators, such as IRAK-M and Tollip. In addition, MΦ subsets differentially responded to inflammation induced by pro-inflammatory cytokines, TNFα and IL-1β in mono- and co-culture models. In conclusion, tolerisation induced in MΦs is presented by the suppression of …
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Low-Input and Single-Cell Transcriptomic Technologies and Their Application to Disease Studies
… mice, we also included TRAM-deficient and IRAK-M-deficient mice. We concluded that low-dose LPS specifically regulates the TRAM-dependent pathway of TLR4 signaling, and high-dose LPS exclusively upregulates exhaustion markers by impacting metabolic and proliferative pathways.