Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"IRAK-4"”.
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Structural and Biochemical Studies of the Innate Immune Pathway
Investigating the biochemical properties of the IRAK-4 DD led to a series of molecular recognition experiments with MyD88. In vitro transcription and translation pull-down experiments performed with IRAK-4 DD and MyD88 suggest that the ID of MyD88 might mediate this interaction.
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Die Rolle der Caspase-1 abhängigen Cytokine, IL-1β und IL-18, bei der hyperoxie-induzierten Schädigung des unreifen Gehirns.
… neuronalen Zellschadens führte. In Versuchen mit IRAK-4 (-/-) Mäusen, welchen die Interleukin-1 Rezeptor assoziierte Kinase 4 fehlt, wurde diese Beziehung zwischen den inflammatorischen Zytokinen und dem hyperoxischen Hirnschaden bestätigt. Bei diesen Tieren ist die intrazelluläre …
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Investigating TLR-4 signalling in response to protein ligands
… four Interleukin-1 receptor- associated kinase (IRAK) 4 and four IRAK1/2 molecules. This triggers a signalling cascade which results in nuclear factor (NF)-κB transcription factor activation and production of pro-inflammatory effector molecules such as the cytokine Tumour Necrosis Factor (TNF)-α. …