Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"IRAK"”.
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Contratistas y otros actores privados durante el conflicto de Irak: (2003-2011)
… de estudio se toma la intervención militar en Irak realizada entre los años 2003 y 2011, periodo durante el cual se analiza el uso de actores privados con fines de lucro empleados como contratistas al servicio del Gobierno de los EE.UU. Parte de la investigación del presente trabajo se realizó …
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Role of IRAK-1 in the Dynamic Regulation of Reactive Oxygen Species
… interleukin-1 receptor associated kinase 1 (IRAK-1) is a key downstream component of TLR4, we test the hypothesis that IRAK-1 may play a critical role in maintaining the balance of LPS triggered ROS generation and clearance. Using wild type and IRAK-1 deficient murine embryonic fibroblasts, …
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The involvement of IRAK-1 in the regulation of NFATc2 in T cells
… for innate immune responses. Here, I report that IRAK-1 also regulates cell-mediated immune responses. NFATc2 (nuclear factor of activated T cells) was found to be associated with IRAK-1 in T cells in vitro and its activity was elevated in the absence of IRAK-1. In addition, IRAK-1-/- mice had …
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The Role of IRAK-1 in the Regulation of Free Radicals and Oxidative Stress during Endotoxemia
… Interleukin-1 Receptor associated kinase (IRAK-1), an intracellular kinase downstream of Toll-like Receptor 4 (TLR4) has been shown to contribute to the inflammatory cascade associated with LPS-TLR4 signaling pathway. However, its role in ROS production has not been defined. Therefore, we …
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Conflictos territoriales, uso de la fuerza y legítima defensa a la luz del conflicto entre Irán e Irak
… desarrollado entre 1980 y 1988 entre Irán e Irak. Así hemos considerado la licitud del uso de la fuerza ("jus ad bellum") prestando atención a los argumentos desarrollados por los contendientes. En primer término, hemos examinado la licitud de su empleo para resolver un conflicto territorial, …
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The Involvement of Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) as a Critical Modulator of Macrophage Migration
… of a key innate immunity signaling kinase, IRAK-1, as a critical modulator of murine macrophage migration. Macrophage migration induced by a potent PKC activator, phorbol 12-myristate 13-acetate (PMA), or lipopolysaccharide (LPS) was significantly decreased in IRAK-1-/- murine macrophages …
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The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
… Interleukin-1 receptor-associated kinase-1 (IRAK-1) is a serine/threonine kinase functioning in Toll-like Receptor signaling pathways, and plays an important role in inflammation and immune response. In our studies, we demonstrated that IRAK-1 is involved with the negative regulation of …
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Die Hemmung der Bildung des Interleukin-1-Rezeptorkomplexes als redoxregulierter antiinflammatorischer Mechanismus
… und die IL-1RI-assoziierte Kinase IRAK werden nach Ligandenbindung an den Rezeptor rekrutiert. Nach ihrer Phosphorylierung dissoziiert die IRAK vom IL-1RI-Komplex und aktiviert weitere Kinasen, was letztendlich zur Aktivierung von NF-κB und zur Induktion der Transkription von Genen …
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Novel Mechanisms Underlying the Inflammatory Effects of Leptin and Low Dose Endotoxin
… Interleukin-Receptor Associated Kinase 1 (IRAK-1) is an intracellular signaling component shown to activate NFκB which leads to the induction of proinflammatory mediators. Deletion of IRAK-1 in mice has beneficial effects in alleviating inflammatory complications and human variations in …
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Structural and Biochemical Studies of the Innate Immune Pathway
Investigating the biochemical properties of the IRAK-4 DD led to a series of molecular recognition experiments with MyD88. In vitro transcription and translation pull-down experiments performed with IRAK-4 DD and MyD88 suggest that the ID of MyD88 might mediate this interaction.
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Identificazione e caratterizzazione di un gene associato all'asma ad insorgenza precoce persistente
… linkage to a portion of 12q13-24. We identified IRAK-M as the gene in the candidate region implicated in early-onset persistent asthma. We defined protective and predisposing haplotypes and replicated associations in an outbred Italian population. Sequence analysis in 100 patients found mutations …
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The IRAK-1 binding protein SIMPL functions as a p65/RELA co-activator in NF-KB dependent gene expression following tumor necrosis factor-alpha stimulation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… of the interleukin-1 receptor associated kinase (IRAK) family to form an oligomeric signalling complex called the Myddosome. Subsequently, IRAK kinases and pseudokinases recruit and activate a number of E3 ubiquitin ligases that trigger downstream signalling events to induce the production of pro- …
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Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
… Interleukin-1 receptor-associated kinase 1 (IRAK-1) is critical for LCN2 expression. In the second study, the molecular mechanisms governing the persistent induction of interleukin 6 (IL-6) upon a 50 pg/mL challenge of LPS in macrophages was examined. At this dose, only the persistent …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… and depends on the TLR signaling molecule IRAK-1 and its kinase activity. Importantly, Listeria monocytogenes induces NLRP3-dependent rapid caspase-1 activation and pyroptosis, both of which depend on IRAK-1. These results demonstrate that simultaneous sensing of microbial ligands and …
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Design and Development of a Novel Immunological Method to Quantify target-specific cysteine redox state in a microplate
… of interleukin 1 receptor associated kinase (IRAK) 1<br/>could not be measured using mobility shift assays. To address this technical<br/>impediment, a novel technique called RedoxiFluor was developed. RedoxiFluor<br/>involves the labelling of reduced, and reversibly oxidised thiols with …
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Az arab-országok és az Európai Unió gazdasági kapcsolatai
… Katar, Egyesült Arab Emirátusok, Omán, Jemen és Irak) valamint az Európai Unió gazdasági, kereskedelmi, politikai, társadalmi és egyéb kapcsolatival foglalkozik. Ezen térség országainak regionális tömbjei és az EU szempontjából fontos országok viszonyait vázolom fel. A két nagy regionális …
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Negative Regulation of Inflammation: Implications for Inflammatory Bowel Disease and Colitis Associated Cancer
… interleukin receptor associated kinase M (IRAK- M), is explored in detail within the present dissertation. Investigation of IRAK-M in mouse models of colitis, which mimics human IBD, and in mouse models of inflammation-driven tumorigenesis, which models colitis associated cancer, …
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U.S. rally effect en la guerra contra ISIS
… la ofensiva contraterrorista estadounidense en Irak y Siria en 2014 que se manifestó en el creciente interés de la ciudadanía por este tema y en los resultados de las encuestas de opinión pública.
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The Role of Foreign Intervention in the Balance of Power System of the Greater Middle East: The Case of Iraq
… régióban azonban talán a központi elhelyezkedésű Irak tekinthető a fegyveres konfliktusok által az egyik leginkább érintett országnak. Irak területe az Egyesült Államok vezette 2003-as inváziót követően gyakorlatilag állandó csatatérré változott, ugyanakkor Bagdad már jóval korábban, Szaddám …
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