Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"IQGAP1"”.
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Investigation of the role of IQGAP1 in metastasis
… This thesis describes the characterization of IQGAP1, a key regulator of the cytoskeleton, as a potentially critical player in metastatic progression. Here I show a strong positive correlation between IQGAP1 expression levels and metastatic progression in both in vivo-selected human metastatic …
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IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
… proteins including the molecular scaffold IQGAP1 and the small GTPase Rac1. Subsequent investigation revealed that the association between Rac1 and IQGAP1 increased with GnRH receptor stimulation and that GnRH increased Rac1 activity. Demonstrating functional relevance, inhibiting Rac1 …
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Identifying a role for the scaffolding protein IQGAP1 in liver health and disease
… IQ motif-containing GTPase-Activating Protein 1 (IQGAP1), an evolutionarily conserved scaffolding protein that is frequently up-regulated in liver disease, in the liver’s response to nutritional and cholestatic stress as well as in liver tumorigenesis. In chapter 2, I review how IQGAP1’s complex …
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Deciphering the roles of scaffold proteins (IQGAP1 and IQGAP2) and xenosensor (CAR) in liver biology
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Intracellular and extracellular promoters of metastasis to different organs
… First, I investigated the scaffold protein IQGAP1, which promotes primary tumor growth and invasiveness in several cancers. However, the role of IQGAP1 in metastasis has been unclear. We used IQGAP1 knockdown and knockout to investigate its role in the metastatic cascade in melanoma and …
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
… I identified the molecular scaffold, IQGAP1. IQGAP1 enhances AMPAR turnover through binding to ubiquitinated AMPARs and promoting receptor internalization. In addition, I also found a decrease in AMPAR abundance following enhanced expression of IQGAP1. Furthermore, activation of …
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The role of PAK6 in HGF-induced prostate cancer cell migration
… IQ motif containing GTPase activating protein 1 (IQGAP1) as a PAK6 binding partner in DU145 cells. Furthermore, PAK6 interacts with IQGAP1 in an HGF-dependent manner and both proteins act synergistically to induce cell colony escape. Additional studies suggest a complex relationship between …
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A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins
… recognised and identified by SEREX 1) and IQGAP1 (IQ motif containing GAP1). The concentration dependent interaction of PARIS-1 and IQGAP1 with PtdIns(3,4,5)P3 was confirmed by an in vitro, SPR based assay. Intriguingly, IQGAP1, a potential tumour promoter, lacks a currently established LBD …
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The Genetics of Differential Fat Distribution: The Insulin Resistance Atherosclerosis Family Study
… In the AA GWAS, novel VSR (MYO18B, PDSS2, and IQGAP1) and VAT (FETUB, PTPRD, STAT3, and FAAH) genes were identified. In the analysis of 99 SNPs within these candidate genes in the AA of the Diabetes Heart Study (DHS), MYO18B was the only gene that illustrated evidence of association for obesity …