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Showing 1 to 1 of 1 for “"IPS-1 Cardif TICAM-1 Picornavirus"”.
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… Hepatitis A virus (HAV), a hepatotropic picornavirus, is capable of blocking IRF3 activation and type I IFN expression in cell culture, but the exact mechanism(s) remains undefined. Our studies revealed that HAV disrupts RIG-I/MDA5-mediated induction of type I IFN through proteolysis of …