Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"IPF"”.
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CHARACTERIZATION AND EVALUATION OF CLINICALLY RELEVANT READOUTS IN A PRE-CLINICAL MODEL OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive age-related interstitial lung disease (ILD) with a poor prognosis and very limited therapeutic options (Raghu et al. 2015; Spagnolo et al. 2018). To date, Pirfenidone and Nintedanib are the only two therapies approved for IPF worldwide. …
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Basis risk and property derivative hedging in the UK : implications of the 2007 IPF Study of tracking error
… the Investment Property Forum study in 2007 (the IPF Study). The thesis first analyzes the risks relevant to hedging and defines the basis risk. Considering hedgers with different objectives measure hedging efficiency differently, this thesis divides the hedging users into two major categories: …
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A study of platelets and the endothelium in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease associated with significant morbidity and early mortality. Despite this, the pathogenesis remains poorly understood and there is no effective disease modifying treatment. Epidemiological studies demonstrate an association between IPF …
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The pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a restrictive pulmonary disorder of unknown aetiology with a relentless disease course and a median survival of 3 years after the diagnosis. It is the most common idiopathic interstitial lung disease (ILD) with a basal and peripheral predominance associated …
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Sex Specific Gene Expression Profiles In Fibrosis and Copd
… (COPD) and idiopathic pulmonary fibrosis (IPF) are chronic progressive lung diseases with rising mortality rates in the United States. Epidemiological studies have revealed gender specific trends in the prevalence and mortality of these diseases such that more males are afflicted with IPF …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
<p>Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia with a median survival time of 2-4 years after diagnosis. The alarming mortality rate is due to the lack of effective treatments. IPF is a chronic disease that is characterized by alveolar destruction due to …
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Clinical evaluation of fibrotic idiopathic interstitial pneumonia
Idiopathic pulmonary fibrosis (IPF) is a fatal condition with limited treatment options. The diagnosis is usually made radiologically but a careful history to exclude identifiable causes of interstitial lung disease is required. Although the median survival is poor, there is considerable …
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Accelerated Sepsis Diagnosis by Seamless Integration of Nucleic Acid Purification and Detection
… by combining immiscible phase filtration (IPF) and digital microfluidic droplet actuation (DM) on a fluidic device. In IPF, as nucleic acid-bound magnetic beads are transported from an aqueous phase to an immiscible phase, the carryover of aqueous contaminants is minimized by the high …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects 5 - 8 million individuals worldwide and 200,000 individuals in the United States alone. Although prevalent, we do not know what causes IPF and no effective curative treatment exists for this disease. Our laboratory has …
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The characteristics of intersitial lung disease patients attending Groote Schuur Hospital Respiratory clinic
… The incidence of Idiopathic pulmonary fibrosis (IPF) is unknown on the African continent. Groote Schuur Hospital (GSH) provides a tertiary referral and follow-up service for patients with suspected ILDs. We set out to determine the burden of IPF and progressive pulmonary fibrosis (PPF) in an …
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Development of an in vitro human lung organoid system to study alveolar type 2 stem cell maintenance and dysfunction during disease
… including Idiopathic pulmonary fibrosis (IPF). The appearance of aberrant cell types within disease-associated honeycomb regions of the distal lung are a hallmark of human IPF. However, the role of hAT2 cells in IPF development has not been fully explored, partially due to current in vitro …
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Approaches to lead generation for idiopathic pulmonary fibrosis targets
Idiopathic pulmonary fibrosis (IPF) is a common and devastating lung disease. There is currently no cure for IPF, and the limited pharmaceutical agents available to patients do not improve lung function, and only give moderate improvements in quality of life. Consequently, IPF is a major cause of …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects about 5 to 8 million individuals in the world. Despite the high prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix …
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Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
<p>Idiopathic Pulmonary Fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death within 2-3 years of diagnosis. IPF incidence and prevalence rates are increasing annually, and because the pathogenesis is unknown, there are no effective treatments available. Inhibition of …
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Spezifische Zytokinmuster und Schrankenstörung bei interstitiellen Lungenkrankheiten
… (EAA) und interstitieller Lungenfibrose (IPF). Unbehandelte Sarkoidosepatienten hatten über den Normbereich erhoehte IL-2 Rez. Werte im Serum, in der BALF konnte der IL-2 Rez. regelmaessig nachgewiesen werden, ein Normbereich ist in der Literatur nicht definiert. Die IL-8 Werte bei …
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Bedeutung der VATS (Video-Assistierte Thorakoskopie) mit Lungenbiopsie in der Diagnostik der idiopathischen interstitiellen Lungenkrankheiten
… ob eine idiopathische Lungenfibrose (IPF) mit ihrem histologischen Bild einer UIP vorliegt, da diese mit einer schlechten Prognose verbunden ist und auf eine immunsuppressive Therapie nur unzureichend anspricht. Dies könnte nach neuesten Erkenntnissen daran liegen, dass die …
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Extending the Information Partition Function: Modeling Interaction Effects in Highly Multivariate, Discrete Data
… of the information partition function (IPF) derived by Engler (2002), Oliphant (2003), and Tolley (2006) that will allow modeling of discrete, highly multivariate data in linear models. We report results of the modified IPF model on the World Health Organization's Survey on Global Aging …
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Advanced Characterization of Nanocrystalline Materials by Synchrotron Radiation X-ray Diffraction
… contribute to the Instrumental Profile Function (IPF). Exploring and characterizing the optical components for powder diffraction beamlines is the bottom line of the present Thesis, with the purpose of properly calibrating and adjusting all components in order to deliver the beam under the best …
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