Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"IP6"”.
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HIV needs the small molecule IP6 to build its capsid
… of the small molecule inositol hexakisphosphate (IP6), which can bind to both the immature (via residues K158 and K227) and mature (R18 and K25) CA lattice is crucial. The data herein demonstrate the importance of these charged rings for viral replication and infection. In the mature capsid, R18 …
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Analysis of Vibrio parahaemolyticus Virulence Systems
… highly similar to the inositol hexakisphosphate (IP6)-inducible cysteine protease domain of several large bacterial toxins. Mutations of conserved catalytic residues and of residues in the putative IP6-binding pocket abolished toxicity in yeast. Furthermore, VPA1380 was not toxic in yeast cells …
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Regulation of Sister-Chromatid Cohesion
… The structure reveals inositol hexakisphosphate (IP6) as an unexpected cofactor of Pds5. The IP6-binding segment of Pds5B engages the N-terminal region of Scc1 and inhibits the binding of Scc1 to Smc3. Our results suggest a direct role of Pds5 in cohesin release from chromosomes by stabilizing a …
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Differential modulation of HIV-1 capsid uncoating kinetics revealed by a novel single-particle uncoating assay
… and the newly discovered CA-binders IP6 and ATP, strongly delay initiation of uncoating but do not prevent subsequent lattice disassembly. We also determined that CPSF6 binds the HIV-1 capsid with higher affinity than previously reported. This is the first report demonstrating the …
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Evaluation of Moving Target IPv6 Defense and Distributed Denial of Service Defenses
… (SYN) Flood, HTTP/GET Flood, Denial6, Dos-New-IP6, and Slowloris attacks. Attacks on the MT6D key distribution mechanism are not considered. Strengths and weaknesses of the aforementioned defenses are presented and analyzed. This project examines different metrics including the performance …
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Biogeoquímica del fósforo en el suelo: optimización de criterios para un uso agronómico eficiente y ambientalmente aceptable de un recurso no renovable
… soil (R2 = 0.49; P < 0.01), also monoesters and IP6, as OP proportion, increased as increased Olsen P in soil in vineyards and olive orchards, where almost no crop residue accumulation occurs. All these results reveal that, under P starvations conditions, some hydrolysis of these OP forms and …
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Structural and biochemical studies of plant inositol phosphate kinases
… signalling beyond simply regulating levels of IP6. At ITPK4, a member of the inositol tetrakisphosphate family, contained a novel additional N-terminal sequence not present in other members of this family as well as a distinctly different kinase activity to other family members. It was …
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Developing an Advanced IPv6 Evasion Attack Detection Framework
… The standard unpack function included in the “ip6” section of the “dpkt” package follows extension headers which means following its parsing, one has no access to all the extension headers in their original order. By defining, a new field called all_extension_headers and adding each header to …
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Cryo-EM as a Tool to Study the Diverse Interactome of Ku 70/80 in NHEJ and Beyond
… stimulator of NHEJ, inositol hexakisphosphate (IP6) (16, 17), which co-purified alongside Ku. Following that, in collaboration with members of our group and cryo-EM facilities in Cambridge, the diverse interactome of Ku with NHEJ components such as DNA-PK, the Ligase IV-XRCC4 complex and XLF was …