Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"IP3R"”.
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitously expressed endoplasmic-reticulum (ER)-resident calcium channel. Calcium release mediated by IP3Rs influence many signaling pathways including those regulating apoptosis. IP3R activity is regulated by protein-protein interactions, …
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Interactions between IP3 receptor and Kras-induced actin-interacting protein
Inositol 1,4,5-trisphosphate receptors (IP3R) function as intracellular channels, facilitating the release of Ca2+ from the endoplasmic reticulum (ER) upon IP3 binding. Before responding to IP3 in intact cells, IP3R must undergo a process called 'licensing,' involving the association with …
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Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors
… The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium channel expressed in cardiac tissue. There are three IP3R isoforms encoded by separate genes. In the heart, the IP3R-2 isoform is reported to being most predominant with regards to expression levels and functional significance. …
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High-resolution optical analyses of IP3-evoked Ca2+ signals
… express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they bind IP3 produced after activation of cell-surface receptors. Vertebrate genomes encode three closely related subtypes of IP3R (IP3R1-3). High-resolution optical analyses …
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Spatio-Temporal Calcium Dynamics of the Interstitial Cells of Cajal
… (ER), through inositol-trisphosphate receptor (IP3R) release, and mitochondria, through the uniporter. In the intestinal regions, a non-specific cation channel (NSCC) is associated with the membrane depolarizations, and is inhibited by intracellular calcium. One theory proposes that the …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… to inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) activation, since they were attenuated by pharmacological inhibition of either phospholipase C or IP3Rs themselves. However, diamide, even at high concentrations, did not increase PIP2 hydrolysis, suggesting diamide increases the sensitivity …
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The dissemination of oncogenic RasV12-transformed cells in the adult Drosophila intestine
… via the inositol triphosphate receptor (IP3R) disassembles E-cad at adherens junctions while Ca2+ entry via Piezo assembles E-cad at invasive protrusions. Thus, our study provides molecular insights into the unconventional role of E-cad in cell invasion during cell dissemination in vivo …
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
… (IP3), activation of IP3 receptors (IP3Rs), release of Ca2+ from the endoplasmic reticulum (ER), and activation of store-operated Ca2+ entry (SOCE). Lysosomes are the core digestive compartments of the cell, but their importance as signalling organelles is also now widely appreciated. …
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Contributions of type 2 IP3 receptors to intercellular adhesions and invasion of glioblastoma cells
… by inositol 1,4,5-trisphosphate receptors (IP3Rs), which mediate Ca2+ release from the endoplasmic reticulum. Mammals express three IP3R subtypes (IP3R1-3). I show that in glioblastoma cell lines, IP3R2 is the least abundant subtype (<5% of all IP3Rs), and that loss of IP3R2 selectively …
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Hyperactivation of human sperm by 4-Aminopyridine: key role for mobilisation of stored Ca2+ in the sperm neck
… of human sperm. 4-aminopyridine induced IP3R and RyR store release in sacroplasmic reticulum and brain microsomal vesicles. Although the physiological factor(s) that activate hyperactivation in vivo remains elusive we can conclude that release of the neck/midpiece intracellular Ca2+ store …
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Identifying new actions of estrogen receptor targetable with small molecules
… cells, BHPI opens the endoplasmic reticulum IP3R calcium channel, triggering efflux of calcium into the cytosol, strongly activating all three arms of the UPR. BHPI activates the PERK arm of the UPR, which leads to phosphorylation of eukaryotic initiation factor 2α (eIF2α), and potent …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
… of EGF receptor (EGFR), PLCγ or IP3 receptor (IP3R) blocks the increase in intracellular Ca2+. While blocking the increase in intracellular Ca2+ by locking the IP3R calcium channel with 2-APB had no effect on EGF activation of the ERK or AKT signaling pathways, it abolished EGF-mediated …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… release through FGFR1/beta-klotho-PLCgamma-IP3R; without affecting protein synthesis on acinar cells. The effect of FGF21 on secretion results in lower levels of ISR activation by decreasing intracellular protein load. However, endogenous FGF21 is downregulated in pancreatitis, which leads …
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Calcium signalling in the nervous system
… (IP3) and inositol 1,4,5-trisphosphate receptor (IP3R) on the endoplasmic membrane. Purinergic signalling was excluded as autocrine trigger of these events. In a second study, I showed that cultivated microglia lack functional NMDA receptors on the plasma membrane. In contrast to the in situ patch …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… at the MAM triggering a phosphorylated IP3R-mediated ER Ca2+ depletion, resulting in the activation of the unfolded protein response. This efflux of Ca2+ is then buffered by the mitochondria, through the MAM, resulting in mitochondrial Ca2+ overload, activation of the caspase cascade and …
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Targeting mdr1 and endocrine therapy-resistant cancers through estrogen receptor
… opens endoplasmic reticulum (EnR) IP3 receptors (IP3R) leading to extremely rapid (<1 min.) efflux of calcium (Ca2+) from the lumen of the EnR into the cell body. Elevated intracellular Ca2+ primes cells for subsequent actions of E2-ER; depletion of EnR Ca2+ activates the unfolded protein response …
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
… both cholesterol homeostasis and regulation of IP3R degradation which functions as an ER calcium channel and mitochondria-ER tether. Once confirmed the identification of these two disease genes will add to the growing literature implicating lipidomic/calcium processing pathways and their …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… of the inositol trisphosphate receptor (IP3R) on the ER membrane and is required for the fission of EGFR/CD147-positive NCE vesicles from the PM. At the functional level, we extended the relevance of NCE to alternative EGFR ligands, beyond the EGF. Saturating doses of the two EGFR …
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Pharmacological regulators of T cell calcium stores
… to T cell growth control. We observed that the IP3R modulator, 2- aminoethoxydiphenyl borate (2-APB) induced antigen-like Ca<sup>2+</sup> spike that correlates with suppression of T cell growth rates.</p> <p>In this study we have identified two novel T cell Ca<sup>2+</sup> store regulators, …
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A MULTIORGANELLE PLATFORM REGULATES EGFR ENDOCYTOSIS AND SIGNALLING
… through the inositol trisphosphate receptor (IP3R), is required, along with the dynamin, for the fission of TIs and the completion of EGFR-NCE. Preliminary data from our laboratory suggested the possible involvement of mitochondria in EGFR-NCE: a significant enrichment in mitochondrial …
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