Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"IP3"”.
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High-resolution optical analyses of IP3-evoked Ca2+ signals
… express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they bind IP3 produced after activation of cell-surface receptors. Vertebrate genomes encode three closely related subtypes of IP3R (IP3R1-3). High-resolution optical analyses …
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Interactions between IP3 receptor and Kras-induced actin-interacting protein
Inositol 1,4,5-trisphosphate receptors (IP3R) function as intracellular channels, facilitating the release of Ca2+ from the endoplasmic reticulum (ER) upon IP3 binding. Before responding to IP3 in intact cells, IP3R must undergo a process called 'licensing,' involving the association with …
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Contributions of type 2 IP3 receptors to intercellular adhesions and invasion of glioblastoma cells
… by inositol 1,4,5-trisphosphate receptors (IP3Rs), which mediate Ca2+ release from the endoplasmic reticulum. Mammals express three IP3R subtypes (IP3R1-3). I show that in glioblastoma cell lines, IP3R2 is the least abundant subtype (<5% of all IP3Rs), and that loss of IP3R2 selectively …
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A quantitative study of neuronal calcium signaling
… release from the endoplasmic reticulum via IP3 receptors which includes diffusion of calcium and IP3 as well as calcium buffering by the mitochondria results in a calcium wave similar to what has been observed experimentally. Finally, I use a branch structure together with IP3 generation, …
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Identifizierung und Funktion von Effektorproteinen der NO/cGMP Signalkaskade
… der cGMP-Kinase I und ihrer Substrate IRAG und IP3-Rezeptor Typ I beschrieben, der für die Steuerung des Calciumausstroms aus Speichern des sarkoplasmatischen Retikulums verantwortlich ist. In der vorliegenden Arbeit sollte dieser mikrosomale Komplex genauer untersucht und die beteiligten …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… were due to inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) activation, since they were attenuated by pharmacological inhibition of either phospholipase C or IP3Rs themselves. However, diamide, even at high concentrations, did not increase PIP2 hydrolysis, suggesting diamide increases …
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Mechanisms of Calcium Wave Initiation and Propagation in Astrocytes
… from inositol-1,4,5-trisphosphate (IP3) dependent stores. This lead to the hypothesis that Ca waves are mediated by mobilization of IP3 in the stimulated cell that then diffuses to surrounding cells through gap junctions composed of Cx43 where it initiates Ca<sup>2+</sup> …
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The role of AMP-activated protein kinase in endothelial VEGF signalling
… endothelial cells via the generation of DAG and IP3. DAG increases Ca2+ influx through a family of non-selective cation channels, whereas IP3 promotes the release of Ca2+ from intracellular stores. High potassium-induced depolarisation, which reduces the driving force for Ca2+ entry through …
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Mode of action of FMRFamide-like peptide on drosophila body wall muscle conractions
… phosholipase C-~ (PLC~) gene (norpA larvae) or IP3 receptor mutants, which suggested that the PLC-IP3 pathway is not involved in mediat ing the peptide's effects. Alatransgenic flies lacking activity of calcium/calmodul in-dependent protein kinase (CamKII showed an increase in muscle tonus …
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Analysing Mathematical Models of Intracellular Calcium Dynamics using Geometric Singular Perturbation Techniques
… a pulse of inositol (1,4,5)- trisphosphate (IP3) is applied to a cell, can be used to distinguish between two competing mechanisms which lead to calcium oscillations [53]. However, detailed mathematical investigation of models has identified an anomalous delay in the pulse responses of some …
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Targeting mdr1 and endocrine therapy-resistant cancers through estrogen receptor
… to the production of inositol triphosphate (IP3). The IP3 binds to and opens endoplasmic reticulum (EnR) IP3 receptors (IP3R) leading to extremely rapid (<1 min.) efflux of calcium (Ca2+) from the lumen of the EnR into the cell body. Elevated intracellular Ca2+ primes cells for subsequent …
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
… and formation of inositol 1,4,5-trisphosphate (IP3), activation of IP3 receptors (IP3Rs), release of Ca2+ from the endoplasmic reticulum (ER), and activation of store-operated Ca2+ entry (SOCE). Lysosomes are the core digestive compartments of the cell, but their importance as signalling …
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Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area
… via an increase in inositol 1,4,5-trisphosphate(IP3) sensitivity. Isolation-mediated effects on Ca²⁺ signaling and NMDAR plasticity were not reversed by a subsequent period of resocialization. Furthermore, social isolation during this critical period occludes the effect of repeated amphetamine …
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Assessing Crosstalk Between Calcium and cAMP in Pancreatic Alpha Cells
… stores. Store release appears to be through IP3 mediated pathways and not through the ryanodine-sensitive receptor.</p>
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Third Order Nonlinearity In III-Nitride Microwave Switches
… is to minimize the level of this distortion. The IP3 (Third order intercept point), a measure of third order distortions level is an important figure of merit for microwave devices.</p> <p>In this work, the 3rd order distortions in III-Nitride switches are studied by using direct two-tone …
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Analyzing a calcium-dependent UV response that results in a global chromatin compaction in mammalian cells
… in HEMs. Chemical inhibition of P2RY6 and IP3 receptors resulted in a significant reduction in calcium influx and chromatin compaction after UV irradiation of cells. Inhibition on other candidate calcium channel, TRPA1, which mediates UVR-induced calcium influx and early melanin synthesis, …
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Characterization of the Tetraspanin protein Tspan18
… was independent of Lyn, Syk, PLC2 and IP3 receptors, which are essential for B cell receptor signalling. However, Tspan18 signalling did require extracellular calcium and the calcium-activated phosphatase calcineurin, which activates NFAT. Additional studies that included the Jurkat T …
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Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
… via mitochondrial Ca2+ uniporter and IP3 receptor critically contribute to celastrol-induced paraptosis-like cell death.
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Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells
… ligand) co-administration on inositol phosphate (IP3) and adenosine 3-,5-cyclic monophosphate (cAMP) release was assessed to study a possible heterologous-interaction or cross-talk between the EP2 and FP receptors. The study showed that in FPEP2 cells, PGF alone does not alter cAMP production, but …
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Cloning and charaterisation of the Thyrotrophin-releasing hormone receptor and Gonadotrophin-relasing hormone receptor from chicken pituitary gland
… diacylglycerol (DAG) and inositoltrisphosphate (IP3)] signalling cascade. The signalling generates the physiological effects of the hormones. The TRH-R and GnRH-R are members of G-protein coupled receptor (GPCR) family. The objective of this thesis was to clone and characterise the chicken TRH …
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