Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"IP-MS"”.
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Investigating the role of nuclear transport proteins secreted by cancer cells
… CaSki cervical cancer cells was used to treat recipient cells, both cancerous and non-cancerous. This was followed by monitoring the uptake of Kpnb1-eGFP and effects on biological phenotypes including proliferation and migration. Our study observed that the internalisation of Kpnb1-eGFP from …
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Molecular Mechanisms of C11orf95 translocations in cancer.
… as well as their transformative potential in multiple murine models. However, the mechanisms by which C11-RELA fusions transform neural stem cells into ependymomas remain elusive. Using multi-OMICS methodologies, we show that oncogenic C11orf95 fusions co-opt spatiotemporally regulated …
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Role of UV90 Gene in the FRQ-Less Oscillator of the Neurospora Crassa Circadian System
Circadian rhythms are found in all domains of life and control many physiological processes. Transcription/translation feedback loops (TTFLs) are important molecular mechanisms in circadian systems. In the model eukaryote Neurospora crassa, TTFL includes FRQ (frequency) and WCC (white-collar …
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Investigating the ubiquitin conjugating machinery in *Plasmodium falciparum*
*Plasmodium falciparum* is the causative agent of the most lethal form of human malaria. In the absence of a vaccine and the emergence of drug-resistant parasites, novel targets against malaria are required. The ubiquitin-proteasome system (UPS), which involves the attachment of the small protein …
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The Role of the ORB2 RNA-binding Protein in Post-transcriptional Regulation
… (RBPs) are key components of the post-transcriptional regulatory framework and can determine the translational fate of their RNA targets. A wide variety of post-transcriptional regulatory mechanisms are employed during the early Drosophila embryo and it has been established as a system well …
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Investigating the functional roles of the viral frameshift protein 2B* in EMCV infection
… pathway. The synergistic relationship between 2B* and caspase-3-mediated cell lysis means that EMCV can induce lysis independently of one of either caspase-3 or 2B* but when both are present lysis occurs more rapidly. Furthermore, interaction partners of 2B* were identified and …
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Inquiries into the Mycobacterial Caseinolytic Protease System
… of noxious host stressors. Along with transcriptional responses, the maintenance of protein homeostasis is critical to this adaptability and pathogenicity. Previous transposon insertion sequencing (TnSeq) screens, in conjunction with our laboratory's work on mycobacterial genetic …
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Investigating nuclear transport proteins as secreted cancer biomarkers
… in oesophageal cancer. Recent mass spectrometry (MS) analysis of cancer cell secreted proteins identified elevated levels of 13 members of the nuclear transport protein family in the secretomes of transformed, cervical cancer and oesophageal cancer cell lines. The nuclear transport proteins have …