Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"IP-10"”.
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Evaluation of IP-10 and TNFalpha-transducing parvoviral vectors as antitumoral agents in animal glioblastoma models
… efficacy of parvoviral vectors expressing human IP-10 or mouse TNFalpha as tools against subcutaneous glioblastoma tumors in two animal models. First, new recombinant MVMp- and H1- based vectors expressing human IP-10 or mouse TNFalpha were constructed. It was shown that parvoviral vectors could …
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
… such as LTC4, LTD4 and LTE4 are proinflammtory lipid mediators synthesized by the 5-lipoxygenase pathway from arachidonic acid and play important roles in eosinophilic chemotactic activity to airway inflammation characterized by bronchoconstriction, mucus secretion and airway hyperresponsiveness …
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ULTRA-LOW LEVEL SOLUBLE P24 IS ASSOCIATED WITH INFLAMMATION IN PEOPLE WITH HIV ON LONG-TERM VIROLOGICALLY SUPPRESSIVE ANTIRETROVIRAL THERAPY
… We therefore seek to investigate whether peripheral inflammation and mortality risk are associated with p24 production in this population. Methods: PWH on suppressive ART and age/sex-matched healthy controls without HIV were enrolled. Ultra-low level serum p24 was cross-sectionally (baseline) …
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Local Inflammatory Responses in Pseudomyxoma Peritonei
… source and biological effect on cell growth.|Multiplex cytokine assays were conducted on 37 ascites and 13 serum specimens from PMP patients to determine the cytokines expressed with a focus on pro-inflammatory cytokines. Tissue sections from 10 PMP specimens were immunostained for interleukin 6 …
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Maternal body mass index and proinflammatory immune markers in HIV-infected pregnant woman on antiretroviral treatment in Cape Town, South Africa
… is a protocol (Part A), journal formatted manuscript (Part B) and Appendices (Part C) for a study on maternal BMI and inflammation in WLWH. A subset cohort from the Prematurity Immunology in HIV-infected Mothers and their infants Study (PIMS) study had three plasma immune markers (c-reactive …
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Impact of long-acting contraceptives on female genital tract cytokine profiles in a randomised controlled trial
… acquisition, among a sub-cohort of ECHO participants. This study included 167 ECHO participants at the Setshaba Research Centre in Pretoria and MatCH Research Unit in Durban, South Africa. Eleven cytokines and antimicrobial peptides were measured in lateral vaginal wall swabs in duplicate using …
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Effekt der Myelinphagozytose auf Makrophagen und Mikroglia in vitro: Suppression inflammatorischer Aktivität und Apoptoseinduktion
Die Multiple Sklerose (MS) ist eine der häufigsten neurodegenerativen Erkrankungen, die im jungen und mittleren Alter zur Behinderung führt und erweckt dadurch schon seit längerem das medizinische Forschungsinteresse. Die Zerstörung der periaxonalen Myelinscheiden im ZNS ist das …
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Enhancing T-Cell Responses to Vaccination of HIV-1 infected Subjects on Antiretroviral Therapy
… found that the pro-inflammatory chemokine IP-10 was elevated in the sera of those infected with HIV-1 while on ART. Additionally, elevated levels of IP-10 were associated with decreased cellular immune responses, which could be improved by neutralizing IP-10 prior to antigen stimulation. …
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The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases
… and the chemokine receptors they express. Multiple sclerosis (MS), subacute sclerosing panencephalitis (SSPE) and coeliac disease (CD), with associated neurological complications, are neuroinflammatory diseases with different aetiologies, but which share common CNS neuropathological features …
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Rekombinante Parvoviren in der Gentherapie von Krebs : Vektorcharakterisierung und Analyse der Wirksamkeit
… MDC (Makrophagen-abgeleitetes Chemokin) oder IP-10 (Interferon--induziertes Protein 10) tragen, in dem Tumormodell RENCA/Balb/c Maus untersucht. Dabei konnten deutliche antitumorale Effekte verzeichnet werden. Im Blickpunkt der Untersuchung stand die Prüfung einer Kombinationstherapie des …
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The Effect of Centrally Administered D-Alanine-Methionine-Enkephalinamide (Dala) on the Copulatory Behavior of Male Hamsters
… opiate antagonist was given intraperitoneal (IP) 10 minutes before DALA ICV. Ten minutes after each administration of DALA, males were exposed to estrus females for 50 minutes and their copulatory behavior observed. Investigative latencies, first mounting latencies, and ejaculatory latencies …
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Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
… at -80°C. Different populations of major peripheral immune cells (CD45+: lymphocytes, monocytes and granulocytes) and CNS-derived immune cells (microglia (CD45-TMEM119+) and astrocytes (CD45-ACSA+) were examined along with their respective sub-groups. The sample supernatants were batch …
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Antibacterial peptides - key players in host defense at epithelial surfaces
… concentrations of the chemokines CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC were found in tonsil fluid. Similarly, these chemokines were produced by activated pharyngeal epithelial cells in vitro. CXCL9/MIG was the predominant chemokine and also the most potent in killing GAS. Epithelial recognition …
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Understanding the role of extrinsic regulators in normal and malignant haematopoiesis
… and in vivo. This work established the principle that core functions of HSCs could be maintained in the absence of the bone marrow microenvironment and allowed the identification of key factors dispensable for HSC function (Chapter 3). Next, to understand the role of extrinsic regulators in …
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Molecular analysis of innate immunity in type 1 diabetes
… susceptibility of TRAIL-deficient NOD.Tnfsf10⁻/⁻ mice and of mice which exhibited allelic Fasl expression (NOD.D1Bax208ᵐ¹ and NOD.D1Bax208ᵐ²). Immune cells from these three mouse lines were systematically characterised by flowcytometry, and their diabetogenic potential determined by adoptive …
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Die Rolle von dendritischen Zellen und Chemokinen bei der Regulation der Immunantwort gegen Erreger der kutanen Leishmaniose
… Netzwerk von heterogenen Zellpopulationen. In peripheren Geweben liegen sie als unreife Zellen mit einem hohen Potential zur Aufnahme und Prozessierung von Mikroorganismen vor. Nach der Aufnahme von eindringenden Mikroorganismen beginnen dendritische Zellen jedoch, sich von einem prozessierenden …
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Host-microbe interactions in the inflamed gut
… whether the probiotic Enterococcus faecium NCIMB 10415 (NCIMB) is capable of reducing chronic gut inflammation by changing the existing gut microbiota composition and aimed to identify mechanisms that are involved in possible beneficial effects of the probiotic. To identify health-promoting …
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Mutations In Stat3 Associated With Human Hyper Ige Syndrome Enhance Nfκb and Mapk-Mediated Gene Expression
… disrupt protein domains responsible for transcriptional function. Patients with HIES display osteoporosis and enhanced inflammatory cytokine production similar to hematopoietic Stat3-deficient mice. Since osteoclast and inflammatory cytokine genes are NFκB targets, these observations indicate a …
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Influence of agglomeration phenomenon in machining of AISI D2 hardened steel using nano chromium powder mixed-EDM
… hardened steel in PMEDM environment by employing 10, 15, and 20 Amps; 20, 25, and 30 μs; 2, 4, and 6 g/L for peak current (IP), pulse duration (Ton), Nano Chromium Powder (NCP) concentration (PC), respectively. These parameters, which are produced by Finite Element Analysis (FEA), predicted the …
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Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10
… states. The CXC chemokine ligand (CXCL) 10 (formerly known as IP-10) is induced locally in the central nervous system (CNS) during diverse neuroinflammatory disorders. In the present study, the impact of CXCL10 production in the CNS was examined in transgenic mice with astrocyte-directed …
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