Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 39 for “"INSULIN RELEASE"”.
-
Somatostatin inhibits insulin release via SSTR2 in the hamster pancreatic islets
… subtype 5 (SSTR5) mediates the inhibition of insulin release. This is due to the fact that in the human, rat, and mouse somatostatin (SST) inhibits insulin release via SSTR5; however, in a preliminary study from Dr. Hsu's laboratory with HIT-T15 [beta]-cells that are derived from hamster …
-
Criticality control of insulin release: a novel alternative for detailed modelling of insulin secretion
… of the dynamic components of the glucose-insulin system has posed a major challenge in the field of physiological modelling for the past six decades. Early stages in development focused on a descriptive approach where mathematical complexity was usually compromised, causing …
-
Mechanism of Insulin Release From Islets of Langerhans in a Rat Model of Normal Infants and Infants of Diabetic Mothers
… is believed to result from persistent insulin hypersecretion due to the elevated glucose concentration in utero. The mechanism for the hypersecretion of insulin is not known. The glucose sensing mechanism in the fetal and neonatal IDM and normal control rats was investigated. Pregnant …
-
The effects of melatonin injection on glucose tolerance in intact and pinealectomized laboratory rats
… activity and thereby reduces glucose mediated insulin release. The objective of this work is to investigate the effects of melatonin on insulin release, and on glucose mediated insulin release in the intact and in the pinealectomized rat.
-
Defining Ankyrin-b Syndrome: Characterization of Ankyrin-b Variants in Mice and Men and the Discovery of a Role for Ankyrin-b in Parasympathetic Control of Insulin Release
… between ankyrin-B and parasympathetic control of insulin secretion. Stimulation of pancreatic beta cells by acetylcholine augments glucose-stimulated insulin secretion by inducing inositol-trisphosphate receptor (InsP3R)-mediated Ca2+ release. We report that ankyrin-B is also enriched in …
-
Regulation of Insulin Secretion in Relation to Nitric Oxide, Carbon Monoxide and Acid alpha-Glucoside Hydrolase Activities
The main stimulus for insulin secretion is elevated blood glucose levels. In this thesis the aim was to study less well-known systems involved in the complex regulation of glucose-stimulated insulin release, emphasizing the role of the lysosomal/vacuolar system and the associated glycogenolytic …
-
Endogenous glucagon-cells are necessary for the glucose-responsiveness of the HIT-T15 hamster β-cell line
The role of glucagon in glucose-stimulated insulin release was investigated using the hamster insulinoma cell line, HIT-T15, as a model of the pancreatic β-cell. Glucose-stimulated insulin release from HIT-T15 cells was concentration-dependent over a range of glucose concentrations between 0 and 15 …
-
Fracture healing : the effects of local insulin delivery via calcium sulfate and tricalcium phosphate
… studies have documented the major role played by insulin in osseous healing. This is the first study to examine local intramedullary insulin delivery to the fracture site and its effect upon the normal fracture healing process. Preceding results show that when administered at the fracture site of …
-
The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
… Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. The increased prevalence of T2D is …
-
Biopolymers for Bioartificial Pancreas
… found in the pancreas. Amongst these cells, the insulin secreting beta cells are targeted by the immune system in Type 1 Diabetes. One of the major challenges islet transplantation has faced is the rapid loss of islets, post-transplantation. To mitigate this, a bioartificial pancreas that …
-
Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-cell function during …
-
Role of Transient Receptor Potential (TRP) Channels in Nociception
… cell dysfunction is responsible for decreased insulin release. TRPV4 is expressed in RINm5F (beta cell line), islets and pancreas. It has been shown that hypotonicity induced insulin release in beta cell lines, which was mediated by activation of stretch-activated channels, raising the …
-
The Development of a Vascularly Implanted Prosthetic Endocrine Pancreas
… was studied in vitro using methylene blue, 125I-insulin and islets from lean and obese mice and optimal physical criteria, i.e. flow rate and perfusion pressure were established. Prototype units provided a constant rate of methylene blue release over a period of 7.5 hours at a flow rate of 0.637 …
-
Shared Metabolic Pathways in Fuel-Stimulated Insulin Secretion
<p>Insulin secretion is a fundamental process of pancreatic beta-cells required for the maintenance of glucose homeostasis. Fuel-stimulated insulin secretion occurs in proportion to the rate of metabolism of fuel substrates, yet the signals generated by metabolism of these secretagogues are …
-
Directed differentiation of endodermal cells from mouse embryonic stem cells
… PCR, immunohistochemistry and static insulin release assay for markers of trilaminar embryo, pancreas and hepatocytes. Inclusion of DBcAMP and extension of culture time resulted in cells that display features of definitive endoderm by expression of Sox 17 and FOXA2 and minimal …
-
Injectable Systems for Long-Lasting Insulin Therapy
… of 2040 causing significant economic burdens. Insulin therapy has been the mainstay of diabetes treatment since its discovery in 1922. However, insulin is an unstable peptide with a half-life of only 4-6 min which poses significant challenge in prolonging duration of action of insulin. …
-
Toxicity and biotransformation of 1,1,1,3,3-Pentafluoropropane, 3,3,3-Trifluoropropionic acid and 1,1,1,3-Tetrachloropropane
… on the involvement of messenger substrates like insulin. Supporting the first mentioned aspect are decreased levels of TCA cycle intermediates, like α-ketoglutarate or citrate, as seen in 1H-NMR spectra of urine. However, the second aspect would explain the drop in blood glucose with the …
-
Relationship of the glycation gap to diabetes and its complications, and the potential role of adipokines
… obesity generates a vicious cycle leading to the release of high level of inflammatory adipokines and this is the link between obesity and CVD. Adipokines are believed to have a role in diabetic complications. This research intends to understand the role some specified adipokines plays in insulin …
-
Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
… in disease has been exhibited in congenital hyperinsulinism, specifically, hyperinsulinism/hyperammonemia syndrome (HHS). GDH catalyzes the reversible deamination of glutamate to 2-oxoglutarate. Mutations in GDH can lead to GDH over activity, causing increased ATP production via the Krebs Cycle …
Page 1 of 2