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Showing 1 to 5 of 5 for “"INSL3"”.
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Untersuchungen zur Regulation des Insl3 Gens
… Arbeit war es zu untersuchen, ob die Insl3-gesteuerte Gubernaculumentwicklung von Androgenen abhängig ist und ob die Überexpression von Insl3 in weiblichen Embryonen zu Entwicklung des Gubernaculums führt und damit den Descensus der Ovarien induziert. Zu diesem Zweck wurden transgene …
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The MA-10 Cell Line as a Model of insl3 Regulation and Leydig Cell Function
… for producing insulin-like peptide 3 (INSL3), a peptide hormone that is essential for testicular descent. The <em>insl3</em> promoter in Leydig cells can be activated by cAMP through the transcription factor Nur77, which has also been shown to regulate the promoters of the steroidogenic …
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Expression of perforin and granzyme variants in adult rat testes after ethylene dimethane sulfonate (EDS)-induced testosterone depletion
… significant reduction in mRNA for Lhr (90%) and Insl3 (99%), and testosterone depletion was confirmed by the undetectable level of testosterone in serum and testes of EDS-treated rats. Due to ablation of testosterone, there was testicular weight loss (18%) along with a significant increase in …
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Untersuchungen zur Expression, Funktion und Regulation ausgewählter Gene der Insulinfamilie
… unter die Kontrolle des Leydigzell-spezifischen Insl3-Promotors gestellt wurde. Die generierten transgenen Mäuse sollten humanes Insulin im Testis produzieren. Durch Northern-Blot-Analyse konnte die Expression der transgenen Konstrukte im Testis gezeigt werden. Auf der Proteinebene wurde mithilfe …
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MORPHOLOGICAL FEATURES OF THE REPRODUCTIVE ORGANS IN DOMESTIC SPECIES IN RELATION TO WATER MOVEMENT CONTROL, HYPONUTRITION AND ENVIRONMENTAL INFLUENCES IN FETAL AND PREPUBERTAL LIFE, AND METABOLISM REGULATOR FACTORS.
… in transabdominal descent of the testes. INSL3, also known as Leydig insulin-like peptide or relaxin-like factor, is supposed to induce the growth of the gubernaculum in male foetuses, thus being directly responsible for the testicular descent in humans and rodents. This is believed to …