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Showing 1 to 4 of 4 for “"INS-1 beta cells"”.
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Dysfunction of Pancreatic INS-1 Beta-Cells Induced by Chronic Exposure to High Glucose
… 베타세포에 악영향을 끼치는 것으로 알려져 있다. 본 연구에서는 백서의 베타세포주인 INS-1 세포에서 고농도 포도당에 지속적으로 노출되었을 때 인슐린 유전자 발현과 그의 전사에 중요한 전사인자들 중의 하나인 pdx-1 유전자 발현이 억제되는 데, 이와 관련된 기작을 연구하고자 하였다. 대상 및 방법: 고농도 포도당의 지속적인 노출에 의하여 베타세포의 중요한 기능 중 하나인 인슐린 유전자 발현이 감소하는 지를 확인하기 위해, 백서의 소도세포와 세포주, 마우스 세포주를 대상으로 RT-PCR 방법을 이용하여 인슐린 및 주요 …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids is postulated to contribute to beta cell dysfunction and beta cell death in type 2 diabetes. Nicotinamide, via its major metabolite NAD+, is involved in a wide range of biological processes, including the …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… and free fatty acids (FFAs) induces pancreatic beta cell dysfunction and death, which may contribute to the development of type 2 diabetes. A deficiency of insulin through loss of beta cell mass, and subsequent impaired compensation against insulin resistance is believed to be a pathogenic cause …
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Genistein-Induced Potentiation Effect on Glucose-Stimulated Insulin Secretion (GSIS) in INS-1 β-cells
Impaired secretion of insulin as well as insulin resistance is a critical characteristic of type 2 diabetes. Thus, correction of the deficient secretion of insulin as well as improvement of insulin action is an important target for prevention of overt type 2 diabetes. Sulfonylureas have been used …