Global ETD Search
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Showing 1 to 9 of 9 for “"INO80"”.
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MODES OF NUCLEOSOME INTERACTION AND MECHANISMS OF THE SACCHAROMYCES CEREVISIAE CHROMATIN REMODELERS INO80 AND ISW1A
… organization. The evolutionarily conserved INO80 and ISW1a complexes mediate these two aspects of nucleosome remodeling, respectively. Despite sharing conserved domain architecture of the core remodeling machinery, chromatin remodelers differ significantly in their modes of interaction with …
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THE UNIQUE STRUCTURE AND MECHANISM OF INO80 - AN ATP DEPENDENT REMODELER OF THE HISTONE EXCHANGER FAMILY
INO80, a member of the multi-subunit SWI2/SNF2 superfamily, is involved in transcription regulation, DNA repair and replication. Not much is known about its substrate specificity and remodeling mechanism or how it differs in comparison to SWI/SNF or ISWI. Site-directed mapping of histone-DNA …
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
… chromatin remodelers- ISWI, SWI/SNF, INO80, and CHD/Mi2. All chromatin remodelers transduce the energy from ATP hydrolysis to translocate on DNA, break histone-DNA contacts, and mobilize nucleosomes. However, the final outcomes of nucleosome remodeling are diverse - nucleosome sliding, …
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HMO2, a yeast HMGB protein that preferentially binds to DNA ends
… a component of the chromatin remodeling complex INO80, which is involved in double strand break repair. I show here using DNA end-joining and exonuclease protection assays that HMO2 binds preferentially to DNA ends. While HMO2 binds DNA with both blunt and cohesive ends, the sequence of a single …
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Characterizing The Role of Uchl5 In Metastatic Melanoma
… with the 26S proteasome complex and the INO80 chromatin remodeling complex. While UCHL5 has been shown to be overexpressed in many cancers, it has not been well characterized in melanoma. We investigated the role of UCHL5 in metastatic melanoma <em>in vitro</em> through overexpressing and …
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Colocalization between Akirin, the NuRD Complex, and Histone Modifications
… animal chromatin remodeling complexes, SWI/SNF, INO80, ISWI, and CHD, we know Akirin interacts with subunits of the SWI/SNF family Brahma (BRM) chromatin remodeling complex during myogenesis and cardiogenesis. Interaction between Akirin and CHD family chromatin remodeling complexes has not been …
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Analyzing Genomic Studies and a Screen for Genes that Suppress Information Loss During DNA Damage Repair
… In addition, I found that the remodeling complex INO80 subunits, ARP8 and IES5 are significant in suppressing SSA.
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The Regulation and Evolution of long, noncoding RNA Transcription
… chromatin remodeling factors: Swr1, Isw2, Rsc, Ino80. I then use strand-specific, high-throughput RNA sequencing (ssRNAseq) to identify the lncRNA targets of these complexes. Further, I go on to show that these factors largely regulate distinct populations of lncRNAs genome-wide, that a subset …
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MECHANISMS OF CHROMATIN REMODELING BY ISWI FAMILY OF REMODELERS: A FUNCTIONAL AND STRUCTURAL INSIGHT INTO THE ROLE OF THE Itc1 SUBUNIT OF ISW2 REMODELING COMPLEX
… classes of remodelers such as SWI/SNF, RSC and INO80/SWR-C. The accessory subunits of some of the ISWI remodelers from yeast have been shown to contact extensively extranucleosomal or linker DNA and appear to be involved in regulating the movement of nucleosomes along DNA. In the ISW2 complex, …