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Showing 1 to 2 of 2 for “"ING4"”.
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Mechanism of Action of ING4 as a Transcriptional Coactivator of p53
<p>ING4 belongs to a family of proteins that have been implicated in tumor suppression and has been linked to the activation of p53 target genes in a p53- dependent manner. However the mechanism by which it interacts with p53 to activate transcription from these genes is unclear. In this study I …
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The Mammalian Hypoxia Response Pathway: Regulation of HIF and HIF Prolyl Hydroxylases
… yeast two-hybrid screen; Inhibitor of Growth 4 (ING4) -a candidate tumor suppressor protein-, and showed that ING4 represses HIF transcriptional activity under hypoxia in a chromatindependent manner. Recruitment of ING4 to alter HIF transcriptional activity represents a novel function of HPH-2. …