Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"INCENP"”.
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Regulated Recruitment of the Chromosomal Passenger Complex to Chromatin and Microtubules Promotes Accurate Cell Division
… its binding to the C terminus of the CPC subunit INCENP, and by localization to the inner centromere, which requires the N terminus of INCENP. Inner centromere localization also requires phosphorylation of histone 3 threonine 3 (H3T3ph). While H3T3ph is required for CPC localization and the SAC …
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Control of Chromosome Segregation by the Aurora B Complex
… passenger complex (CPC), known to include Incenp, Survivin, and the kinase Aurora B. We report the identification of Dasra A and Dasra B as two new components of the vertebrate CPC, and demonstrate that the CPC is required for chromatin-dependent spindle formation in Xenopus egg extracts. …
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Analysis of Aurora B Regulation and Signaling
… two other chromosomal passenger proteins called INCENP and Survivin. Its function is implicated in a variety of processes related to mitosis, such as chromosome condensation, regulation of arm cohesion, spindle assembly, chromosome bi-orientation and cytokinesis. During the cell cycle, the level …
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The role of the chromosomal passenger complex and condensin complex in meiotic chromosome cohesion and segregation
… as an allele of the passenger complex component incenp.
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Mechanistic Insights into the Microtubule-Mediated Differential Modulations of Aurora B Substrate Structures for Accurate Chromosome Segregation
… it binds via the single α-helix domain of the INCENP subunit in a conserved manner across species. The CPC and MCAK partially share overlapping microtubule-binding sites, and cryo-EM-based co-decoration assays demonstrate that the CPC competitively displaces MCAK from the microtubule lattice. …
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Investigating the function of Citron kinase and its regulation by other mitotic kinases
… patients), only one known CIT-K substrate, INCENP, has been identified so far. To assess the role and function of CIT-K kinase activity I employed the chemical genetic approach of generating an analogue sensitive (AS) variant capable of accepting a “bulky” ATP analogue that would selective …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
… N-Myc and Aurora A that mimic the interaction of INCENP with Aurora B and helped to generate a model of the complete interaction of N-Myc with Aurora A that will help guide future efforts that aim to dissociate the Aurora A:N-Myc complex. Taken together, the cooperativity patterns observed in both …