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Showing 1 to 20 of 81 for “"IN VITRO RELEASE"”.
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In vitro release of endogenous monoamine and amino acid transmitters from rat brain synaptosomes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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A 'Biorelevant' Approach for Accelerated In Vitro Release and In Vitro-In Vivo Relationship of a Biodegradable, Naltrexone Implant
Characterization of in vitro and in vivo drug release profiles constitutes an important step in developing and optimizing an effective, long acting delivery system for naltrexone. Accelerated in vitro methods are also important for quality assurance of manufactured dosage forms. For drug release …
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Computational and Experimental Studies of Controlled Release Drug Delivery: Effect of Microsphere Diameter and Drug Size on in-Vitro Release Kinetics
… microsphere size affects small-molecule, protein and oligonucleotide release have been clarified in this work.
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Photosensitizer Loaded Contact Lenses As An Externally Stimulated Ophthalmic Drug Delivery System
Ophthalmic administration of drugs is primarily associated with the treatment of ocular diseases. 90% of the ophthalmic dosage forms are given topically. However, following the topical route, only 5% ocular bioavailability is achieved. The aim of my work is to address the problems associated with …
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Sex Differences in Catecholamine Release From Brain Tissue in Vitro
A continuous flow perifusion system was developed to measure the in vitro release rate (pg/mg/min) of endogenous catecholamines (CA) from rat brain tissue. This system was employed to measure CA release from 2 brain areas, the mediobasal hypothalamus (MBH) and the striatum. The K('+)-stimulate
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IN VITRO ΜΕΛΕΤΗ ΤΗΣ ΑΠΟΔΕΣΜΕΥΣΗΣ ΤΩΝ ΑΝΤΙΡΡΕΥΜΑΤΙΚΩΝ ΦΑΡΜΑΚΩΝ: ΦΑΙΝΥΛΟΒΟΥΤΑΖΟΝΗΣ, ΝΑΠΡΟΞΕΝΗΣ, ΝΑΤΡΙΟΥΧΟΥ ΝΑΠΡΟΞΕΝΗΣ ΚΑΙ ΝΑΤΡΙΟΥΧΟΥ ΤΟΛΜΕΤΙΝ...
THE IN VITRO RELEASE OF THE ANTI-INFLAMMATORY DRUGS FROM OINTMENT BASES WAS STUDIED USING THE SARTORIUS ABSORPTION SIMULATOR. THE AMOUNT OF DRUG RELEASED DEPENDED ON THE COMPOSITION OF THE VEHICLE. THE RATE OF RELEASE INCREASED IN THE FOLLOWING ORDER: OINTMENT<W/O EMULSION<O/W EMULSION<GEL. THE …
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Functional Interactions Among Thyrotropin-Releasing Hormone (Trh), Prolactin (Prl) and Dopamine (Da) in the Brain
The goals of my thesis research centered in the study of the mechanisms that regulate the in vitro release of thyrotropin-releasing hormone (TRH) from the mediobasal hypothalamus (MBH) and in the actions of prolactin (PRL) on the activity of dopaminergic neurons in the striatum and the MBH. In the …
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Development of biodegradable implants for sustained drug delivery
The advent of sustained drug delivery has resulted in many patient benefits including reduced frequency of drug administration and reduced side effects. Implantable drug delivery benefits from these advantages, but importantly, can be removed if adverse effects necessitate it. In this thesis, …
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Advanced Engineering of Contact Lens Coatings using Electrohydrodynamic Atomization
… methods. Despite the exponential growth in research to overcome these downfalls and achieve sustained and controlled DD, the anatomical characteristics of the eye still pose formulation challenges. The research presented in this thesis utilises Electrohydrodynamic Atomization (EHDA) to …
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Fabrication of drug delivery MEMS devices
There is considerable amount of interest in the immediate treatment of personnel involved in high risk situations on the battlefield. A novel approach to drug delivery on the battlefield based on MEMS technology is discussed. By combining three separately fabricated layers, a single implantable …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
Allergic diseases continue to pose a significant global health challenge, highlighting the need for more effective, patient-friendly therapeutic approaches. Although antihistamines remain the cornerstone of allergy treatment, their conventional oral administration is limited by extensive first-pass …
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Studies into the release mechanisms of human placental lactogen in vitro
A procedure to study the in vitro release of HPL was developed. Hormone release, partially uncoupled from hormone biosynthesis, was measured by incubating placental fragments in physiological salt solutions for short periods. The effect of test substances and different ionic environments on HPL …
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Injectable in situ Gelling Metronidazole System for Treating Jawbone Infections
… dental cavity or an accumulation of bacteria in the side of the teeth or around an implant can cause jawbone infection. This is treated by incision and drainage, root canal treatment or extraction in combination with a prolonged course of antibiotic therapy. Metronidazole is effective against …
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NANOPARTICLE DEPOT FOR INTRAPERITONEAL CHEMOTHERAPY OF OVARIAN CANCER
Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of ovarian cancer, with the full potential yet to be proven. To facilitate IP chemotherapy of ovarian cancer, we have developed a nanoparticle depot for IP chemotherapy consisted of paclitaxel (PTX) nanocrystals (PNC) and …
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Interaction of Human umbilical vein endothelial cells and human hepatocytes celline on Gelatin-VEGF Microspheres and PHBV-HGF Microspheres in co-culture
… PHBV microspheres and VEGF encapsulated gelatin microspheres to ensure controlled release of growth factors as the microspheres degrade during cell culture. Blank microspheres and 2D cell cultures were used as controls. Characterization of the microspheres was done by SEM, in-vitro degradation …
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Brain distribution and release of Cholecystokinin octapeptide
In this thesis the in vitro release of immunoreactive CCK₈ (iCCK₈) from rat central nervous system preparations and the regulation of this release have been studied. Rat brain was dissected into the following regions; hypothalamus, cerebral cortex, striatum and thalamus, according to the method of …
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Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
… (RTB) were successfully synthesized by ring opening copolymerization method. RTB copolymers are composed of FDA approved materials such as polyethylene glycol (PEG), glycolide (GA), lactide (LA) and ɛ-caprolactone (CL). RTB copolymers were synthesized and developed for sustained delivery …
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The targeting of corticosteroids to inflamed tissues
In recent years, much interest has focused on the beneficial effects of administering potentially harmful therapeutic agents in drug carriers so as to reduce their toxic side effects. Rheumatoid arthritis is a chronic systemic disease with progressive destruction of the Joints and long term patient …
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Obtenção e avaliação do potencial imunoadjuvante de nanopartículas de quitosana na produção de antissoro contra a peçonha da serpente Crotalus durissus cascavella
Snakebite envenoming is a tropical disease neglected in many regions of the world world. In Brazil, the Crotalus durissus cascavella (CDC) snake belongs to a genus with venom of highest lethality. A search for new immunoadjuvants aimed to expand the therapeutic alternatives to improve vaccines and …
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Designing and characterizing the plant-based chitosan-modified poly (lactic-co-glycolic acid) nanoparticles for salmonella and e. coli-induced gastroenteritis
… rate of over 1.6 million deaths was reported in 2017 due to gastroenteritis. The highest mortality rate is reported annually in sub-Saharan Africa and South Asia. In Namibia, the national prevalence of gastroenteritis was 17% in 2014 and to date, gastroenteritis is responsible for 5% of all …
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