Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"IMPDH"”.
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Der Einfluss von Mycophenolat-Mofetil (MMF) auf die renale Fibrogenese: Bedeutung für neue therapeutische Ansätze
… Inosinmonophosphat-Dehydrogenase (IMPDH) zurückgeführt wird, zeigen diese Ergebnisse erstmals neben der IMPDH-abhängigen Inhibition der Fibroblastenproliferation und des Wundverschlusses eine bisher nicht beschriebene IMPDH-unabhängige Inhibition der Kollagenmatrix-Kontraktion. Ein …
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Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients
… from 0.4-1.06%. The mean percent inhibition of IMPDH activity at Cmin and Cmax were 13.05B116.45 and 67.24B115.56% respectively.Structure basic and final model for PK and PD were developed using non linear mixed effects modeling. White blood cell count appeared to be the sole important covariate …
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Structure of T6SS components and assessment of potential Gram-ve drug targets
… presented. The characterisation of P. aeruginosa IMPDH, an essential protein that is present in nearly all living organisms is described in chapter 7. This protein controls the pool of guanine nucleotides within cells. Fragments were identified using bio-layer interterformetry, a label free …
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Proteomic investigation of the molecular targets of mycophenolic acid in human cells
… of inosine monophosphate dehydrogenase (IMPDH), a key regulator of purine biosynthesis. MPA is frequently used as an immunosuppressant drug to prevent acute graft rejection for kidney, liver and lung transplantation. The use of MPA is associated with GI toxicity which is a problem to the …