Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"ILC3"”.
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Investigating the role of IgG and Fcγ receptors in intestinal inflammation
… between IgG and group 3 innate lymphoid cells (ILC3s). ILC3s are closely related to natural killer cells, which are known to express FcγRs, and are characterised by their production of Th17 cytokines. Here, we have shown that ILC3s express FcγRs, that ICs drive IL-22 production and MHC class II …
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Innate memory to bacterial infection
The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, …
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
… newly described group 3 innate lymphoid cells (ILC3s). They contributed significantly to the establishment of the early cytokine milieu in virus-infected mouse livers. Functional studies with mice deficient of IL-17 receptor, IL-17A, and IL-17F further revealed that IL-17 signaling was critical …
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Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
… profiles. This project focussed on type 3 ILCs (ILC3s) found primarily at mucosal surfaces with roles in immune defence, tolerance and homeostasis. The key aims were to identify ILC3s within the renal tract (bladder, ureter and kidneys) and characterise their role in urinary tract infection …
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
… prior to differentiation into ILC1, ILC2 and ILC3 subsets in an in vitro co-culture system. Using IL-13 expression as a readout, Nfkb2, Mef2d, Zfp871 and ADNP were identified and validated as novel regulators of CLP to ILC2 development and differentiation. Furthermore, screens using CLP from …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… (Mc5r), as expressed more highly by ILC2 than ILC3. Treatment of mice with the neuropeptide alpha-melanocortin-stimulating hormone (αMSH), an agonist for melanocortin receptors, induced increases in the proportions of lung NK cells and T cells. The generation of a mouse line in which Mc5r was …
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UNVEILING HUMAN NATURAL KILLER CELLS ONTOGENESIS IN HOMEOSTATIC CONDITIONS AND DURING THE IMMUNE RECONSTITUTION AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION
… NK cells. These h-ILCs mostly belong to the h-ILC3/p subset, confirming their nature of precursors also for NK cells. additionally, we highlight cCD56bright NK cells as driver of NK cell differentiation both in vitro and in silico. This is true also for the process of IR after h-HSCT, where …
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Innate Lymphoid Cell Characterization and Ilc2S In Neuroinflammation In Aging and Sex Differences
<p>Aging affects immunologic responses by a global immune system suppression, including dysregulation of cytokine mediators, leading to increased inflammation throughout all systems, termed inflammaging. However, understanding healthy aging mechanisms can bypass this effect. Inflammaging also leads …