Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"ILC2s"”.
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Innate Lymphoid Cell Characterization and Ilc2S In Neuroinflammation In Aging and Sex Differences
… output of group 2 innate lymphoid cells (ILC2s) within aging and sex difference models using flow cytometry. Moreover, aging increases susceptibility to many diseases, including those in the brain. Therefore, this study elucidates ILC2/microglia immune crosstalk from brain tissue <em>in …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… (IL-25) and group 2 innate lymphoid cells (ILC2s) play critical roles in the host immune defense against intestinal parasitic helminth infections, through orchestrating the protective type 2 immune response, eliciting pathogen clearance, and promoting tissue repair. However, IL-25 and ILC2s …
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Investigating the role of innate lymphoid cells in targeted radiotherapy in lung cancer
… microenvironment in lung cancer. In the lung, ILC2s are critical innate lymphocytes that modulate Type 2 immunopathology, but their role in modulating the immune response to lung cancer is not fully understood. Furthermore, it is unclear how ILC2s respond to targeted lung radiotherapy. In this …
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
Type 2 Innate Lymphoid Cells (ILC2s) are recently discovered tissue resident immune cells, studied more commonly in barrier tissues like the lung and intestine. ILC2s are critical mediators of early type-2 immune responses and play a crucial role in the clearance of parasites, but also in the …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… Key lymphocytes – type 2 innate lymphoid cells (ILC2s) and T helper 2 (Th2) cells – express the effector cytokines IL-4, IL-5, and IL-13 which drive the canonical “weep and sweep” responses that are critical for resistance to parasitic helminth infections. Emerging evidence indicates …
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Imaging innate immune cell behaviour in lymphoid organs
… pathogen killing. Type 2 innate lymphoid cells (ILC2s) mediate early responses to helminths and allergens via cytokine production. Innate immune cells interact with adaptive immune cells, for example via major histocompatibility complex class II (MHCII) expression for antigen presentation. …
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Characterising the crosstalk between pancreatic fibroblasts and group 2 innate lymphoid cells in pancreatic homeostasis, inflammation, and neoplasia
… neoplastic states. The majority of pancreatic ILC2s were localised together with a subset of *Pi16<sup>+</sup>Ly6c1<sup>+</sup>Dpp4<sup>+</sup>Il33<sup>+</sup>* fibroblasts within an unappreciated interstitial niche beneath the submesothelial surface and within the interlobular septae of the …
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Group 2 innate lymphoid cells and reproduction
… is unknown. Among them, group 2 ILCs (ILC2s) have been previously characterised in other tissues, in which they modulate immune cells and tissue homeostasis by producing type-2 cytokines and growth factors (i.e. IL-4, IL-5, IL-13, and Amphiregulin). Based on these premises, I …
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The role of innate immunity in pancreatic cancer progression and treatment
… role of type 2 innate lymphoid cells (ILC2s) in PDAC. In chapter 3, Gem/ATRi showed preclinical efficacy in the ‘T cell high’ 2838c3 tumour model and induced dendritic cell (DC) activation in both the tumour and draining lymph node (LN). This was associated with a substantial depletion …
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The Impact of IL-9 on Disease in Murine Models of Systemic Lupus Erythematosus
… arthritis, type II innate lymphoid cells (ILC2s) secrete increased IL-9 to promote the suppressive response of regulatory T (Treg) cells. As such, the role of IL-9 may be context-dependent and requires further investigation in SLE. This thesis examines standard and novel murine models of …
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Identifying regulators of natural killer cell development through CRISPR screening of common lymphoid progenitors
… also comprises the functionally divergent ILC1s, ILC2s, ILC3s and lymphoid tissue inducer (LTi) cells. Most NK cells arise from progenitors in the bone marrow (BM), from which other ILCs are also derived. However, the precise signals that specify the commitment of ILC progenitors to the NK cell …
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Sources of Pulmonary GM-CSF and Its Roles in Myeloid Cell Homeostasis
… in distinct lymphoid compartments, such as ILC2s and γδ T cells. Overall, our studies reveal that diverse epithelial and lymphoid sources of GM-CSF differentially regulate the homeostasis of tissue myeloid cells in a tissue-specific manner.
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… activation of type 2 innate lymphoid cells (ILC2s), which promoted secretion of Th2 cytokines IL4, IL6, and IL13, thus enhancing inflammatory responses. This pathway presents a potential target for therapeutic intervention, particularly in managing colon inflammation and cancer. The third …
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
… helper-2 (TH2) and type 2 innate lymphoid cells (ILC2s) play important roles in parasite expulsion, wound healing and allergic diseases through the expression of type 2 cytokines including IL-4, IL-5 and IL-13. Central to lymphocyte function are molecules required for differentiation and …
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IL-25 and B cells in atherosclerosis
… trigger for this mechanism is the expansion of ILC2s. Additionally, blockade of endogenous IL-25 at the onset of atherosclerosis led to increased plaque formation of unstable phenotype, accompanied by a Th1/Th17 shift of the cytokine balance in the spleen of the mice. The above mentioned …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such as goblet cell mucus secretion and mast cell activation driving disease resolution. Finding candidate molecules and discrete cell populations that enhance these responses would provide …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such as goblet cell mucus secretion and mast cell activation driving disease resolution. Finding candidate molecules and discrete cell populations that enhance these responses would provide …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… that p38 is crucial for cytokine production in ILC2s. MK2 and MK3, two kinases downstream of p38, were also found to regulate production of IL-6 and IL-13. In addition to cytokine production, stimulation of ILC2 cells with IL-33 induced an increase in ILC2 size and granularity. Moreover, IL-33 …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
… secretion of IL4 by CD4+ T cells and ILC2s in cysLTR1-/- mice compared with wildtype mice. Furthermore, we observed reduced granulomatous inflammation in the lungs of chronically infected cysLTR1-/- mice despite the heightened Th2 immune response in the lungs. Collectively, these data …