Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"ILC2"”.
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The role of tissue-resident immune cells in PanIN to PDAC progression
… Tissue-resident group 2 innate lymphoid cells (ILC2) are emerging as important immune modulators of the cancer microenvironment, although their role in PDAC remains contentious with both pro- and anti-cancer roles having been described. In this thesis, I have characterised the role of ILC2 in …
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
Type 2 Innate Lymphoid Cells (ILC2s) are recently discovered tissue resident immune cells, studied more commonly in barrier tissues like the lung and intestine. ILC2s are critical mediators of early type-2 immune responses and play a crucial role in the clearance of parasites, but also in the …
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Characterising the crosstalk between pancreatic fibroblasts and group 2 innate lymphoid cells in pancreatic homeostasis, inflammation, and neoplasia
Group 2 innate lymphoid cells (ILC2) are important orchestrators of type 2 inflammation with established roles in anti-helminth immunity and allergic disease. More recent studies have shown both pro- and anti-tumourigenic functions, indicating our incomplete understanding of their role in cancer. …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… repertoires of immuno-regulatory cytokines. ILC2 and natural killer (NK) cells are generated in the bone marrow and thymus, whilst T cell development is restricted to the thymus. Once in the tissues, these cells respond to microenvironmental cues that refine their responses, for example, via …
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
… helper-2 (TH2) and type 2 innate lymphoid cells (ILC2s) play important roles in parasite expulsion, wound healing and allergic diseases through the expression of type 2 cytokines including IL-4, IL-5 and IL-13. Central to lymphocyte function are molecules required for differentiation and …
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Imaging innate immune cell behaviour in lymphoid organs
… pathogen killing. Type 2 innate lymphoid cells (ILC2s) mediate early responses to helminths and allergens via cytokine production. Innate immune cells interact with adaptive immune cells, for example via major histocompatibility complex class II (MHCII) expression for antigen presentation. …
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The role of innate immunity in pancreatic cancer progression and treatment
… role of type 2 innate lymphoid cells (ILC2s) in PDAC. In chapter 3, Gem/ATRi showed preclinical efficacy in the ‘T cell high’ 2838c3 tumour model and induced dendritic cell (DC) activation in both the tumour and draining lymph node (LN). This was associated with a substantial depletion …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… to modulate their response. Stimulation of ILC2 cells with IL-33 induced phosphorylation of p38 and ERK1/2 and secretion of IL-13, IL-5, IL-6, IL-9 and GM-CSF. Inhibition of p38 using the specific inhibitor VX745 showed that p38 is crucial for cytokine production in ILC2s. MK2 and MK3, two …
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Innate Lymphoid Cell Characterization and Ilc2S In Neuroinflammation In Aging and Sex Differences
… output of group 2 innate lymphoid cells (ILC2s) within aging and sex difference models using flow cytometry. Moreover, aging increases susceptibility to many diseases, including those in the brain. Therefore, this study elucidates ILC2/microglia immune crosstalk from brain tissue <em>in …
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
… that exogenous IL-33 promoted the expansion of ILC2 (nuocytes), a recently described immune cell type whose lineage is negative and produces Th2 cytokines. Thus, we examined whether ILC2 lead to the immune protection exerted by IL-33 in viral hepatitis. When we co-cultured ILC2 with intrahepatic …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… expansion and eosinophilia without affecting ILC2 and CD4+ Th2 cell recruitment. In addition, exposure of naïve TG neurons to allergen evoked calcium influx and neuropeptide release, but only Substance P (SP) adaptively increased upon repetitive allergen exposure. We found that SP not only …
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Innate memory to bacterial infection
The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… (IL-25) and group 2 innate lymphoid cells (ILC2s) play critical roles in the host immune defense against intestinal parasitic helminth infections, through orchestrating the protective type 2 immune response, eliciting pathogen clearance, and promoting tissue repair. However, IL-25 and ILC2s …
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IL-25 and B cells in atherosclerosis
… LDL (oxLDL) via innate lymphoid cell type 2 (ILC2)-derived IL-5. We suggest that the essential trigger for this mechanism is the expansion of ILC2s. Additionally, blockade of endogenous IL-25 at the onset of atherosclerosis led to increased plaque formation of unstable phenotype, accompanied …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such as goblet cell mucus secretion and mast cell activation driving disease resolution. Finding candidate molecules and discrete cell populations that enhance these responses would provide …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such as goblet cell mucus secretion and mast cell activation driving disease resolution. Finding candidate molecules and discrete cell populations that enhance these responses would provide …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… Key lymphocytes – type 2 innate lymphoid cells (ILC2s) and T helper 2 (Th2) cells – express the effector cytokines IL-4, IL-5, and IL-13 which drive the canonical “weep and sweep” responses that are critical for resistance to parasitic helminth infections. Emerging evidence indicates …
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
… innate anti-viral immunity, increased IL-33, ILC2 and IL-5 responses, as well as significant eosinophilia. Interestingly, abolition of canonical Th2 immune signalling by the lack of IL-4Rα expression, enhanced innate anti-viral defences and provided protection from HSV-2 pathology. However, N. …
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Investigating the role of innate lymphoid cells in targeted radiotherapy in lung cancer
… microenvironment in lung cancer. In the lung, ILC2s are critical innate lymphocytes that modulate Type 2 immunopathology, but their role in modulating the immune response to lung cancer is not fully understood. Furthermore, it is unclear how ILC2s respond to targeted lung radiotherapy. In this …
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The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation
… and an accompanying increased IL-33 induced ILC2 driven inflammation in the lung responsible for the exacerbation of TH2 acute disease. Conclusively, the IL-4Rα responsive Foxp3+ T regulatory cells are key in maintaining tolerance in type 2 innate immune driven allergic asthma, therefore the …
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