Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"IL7"”.
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
… eradication. Here, we orthotopically delivered IL7 and/or Flt3L expressing CAR T cells in 50% EGFRvIII-positive and -negative tumors pre-conditioned with non-lymphodepleting irradiation. IL7 and IL7 Flt3L CAR T cells increased intratumoral CD8 CAR T cell populations seven days after treatment. …
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Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia
… but most dominantly by Interleukin7 (IL7), and 2) Cell-intrinsic functional-loss of IKAROS. Utilizing IL7-deficient recipient mice, we demonstrated that physiological levels of IL7 significantly attenuate the survival benefit derived from dasatinib monotherapy against Ph+ ALL. …
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Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells
… capacity to proliferate both in response to IL7 alone or identical stimulation of the TCR, pathway (same dose of PMA/ionomycin) as compared to CD51' cells. In contrast, CD510 cells survive better in conditions of cytokine deprivation. The selective proliferation in response to IL7 as well as …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… as well as molecules (*Il13ra1*, *Il4ra*, *Il7*) not previously implicated in intestinal neuro-immune interactions. Generation of a mouse strain, *Nmu<sup>Cre-iRFP670</sup>*, enabled the interrogation of how NMU-ergic neurons regulate type 2 immunity. Confocal microscopy imaging of tissues …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
… factors E2A, HEB, EBF1 and FOXO1 as well as the IL7 signaling cascade. The objective of this thesis has been to increase our understanding of the transcriptional network orchestrating B-lineage specification and commitment. Based on the combined expression of surface markers and transgenic …
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Combined chemotherapy and immunotherapy against experimental malignant brain tumors
… when combining immunization with IFNγ- and- IL7-producing tumor cells and this coincides with enhanced systemic proliferation of CD4+ and CD8+ T cells, and an increase in the plasma levels of IFNγ, thereby strengthening the anti-tumor immune response. In addition the synergistic therapeutic …
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Enhancement of Hiv Persistence By Adipose Tissue
… ubiquitous common gamma-chain cytokines, IL2, IL7, or IL15. Adipocytes further enhanced T cell viability and even mitigated the viral suppressive effects of some antiretroviral drugs. To determine if adipose depots are sites for HIV persistence in vivo, adipose tissues of infected humans and …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… produce Thymic Stromal Lymphopoietin (TSLP), an IL7-like cytokine, which potently activated human myeloid dendritic cells (mDC) to cause the homeostatic proliferation of autologous CD4+ T cells that serve as targets for HIV infection. Rhesus macaques inoculated with simian immunodeficiency virus …
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Development and Evaluation Of HIV gp120 Responsive Microbicide Formulation for the Prevention of HIV Sexual Transmission
… pro-inflammatory cytokines (IL1α, IL1β, IL6, IL7, MKC and TNFα) release at concentrations ≥ 100 µg/ml. Conversely, 𝐶+𝑀𝑅𝑃 did not induce any significant changes in VK2 and RAW 264.7 cells viability nor in pro-inflammatory cytokines’ levels, in the concentration range tested (≤ 1000 µg/ml), for …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… marrow stromal cells in the presence of IL15, IL7, FMS-like tyrosine kinase 3 ligand: Flt3L) and stem cell factor: SCF). Flow cytometry results showed NK1.1<super>&plus</super> cells emerged after at least 7 days in culture. By using limiting dilution analysis, we demonstrated a cell frequency …
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Can curcumin improve the methotrexate based treatment for rheumatoid arthritis?
… CD248, CH25H, COL14A1, CXCL12, CYTL1, IFITM1 and IL7. Curcumin was found to also increase the expression levels of genes associated with anti-inflammatory roles, namely BCAR4, CD274, HSPA6, OTP and RELT. The increased gene expression in samples treated with both MTX and curcumin confirmed the …