Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"IL6"”.
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Supplementing IL6, IL11, and LIF to Improve Cultured Bovine Oocyte Competency
… development. LIF is another family member of the IL6 cytokine family and has been shown to produce several positive effects when supplemented during oocyte in vitro maturation. IL6 has predominantly been studied as being supplemented post-fertilization. However, published transcriptomic work …
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Regulation of mRNA expression through 3’ UTR sequences of IL6 gene in amino acid-deprived HeLa cells
… transcriptional factors subsequently to induce IL6 cytokines. Here, it was investigated whether 3’UTR of IL6 mRNA played a role in IL6 induction through cellular stress responses. In the studies with GFP-reporter containing 3’UTR of IL6 mRNA, it was elucidated that 3’UTR contributed to increase …
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DNA Sequence and Haplotype Variation Analysis of Inflammatory Response Genes NLRX1, IL6, and IL8 in the Turkey (Meleagris gallopavo)
… genes screened in this project: Interleukin 6 (IL6) and 8 (IL8), and NLRX1. Mortality data from the LPS challenge were not significantly different among the strains. Further gene expression analyses will be part of future work. The SNP data represent the first extensive analyses of candidate …
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Investigating the Actions of Interleukin-6 Family Members on Post-Hatching Blastocyst Development in Cattle
… selective members of the interleukin 6 (IL6) cytokine family influences post-hatching in vitro produced (IVP) bovine blastocyst development. The first series of studies determined if adding human recombinant IL6 improved IVP blastocyst quality before and after cryopreservation. Adding IL6 …
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Mechanismus der Hemmung der glucagon-stimulierten Phosphoenolpyruvat-Carboxykinase-1-Genexpression durch das proinflammatorische Interleukin 6 in primär kultivierten Rattenhepatozyten
… zur Hypoglykämie. Interleukin-6 (IL6) ist der Hauptmediator der hepatischen Akut-Phase-Reaktion. In kultivierten Rattenhepatozyten hemmte IL6 die durch Glucagon ausgelöste Steigerung der Phosphoenolpyruvat-Carboxykinase-1-(PCK1)- Genexpression und den die Steigerung vermittelnden …
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Tissue specific genetic regulation of Interleukin 6
Interleukin 6 (IL6) is associated with arterial disease development, progression and surgical outcome. Raised levels of IL6 may play a causal role in disease development or may be the effect of pathology. An IL6 single nucleotide polymorphism (SNP) G- 174C has been identified and reported to …
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Interleukin-6 Supplementation Improves Post-Transfer Embryonic and Early Fetal Development of in vitro Produced Bovine Embryos
… work in this thesis explored how interleukin-6 (IL6), an embryokine that increases inner cell mass (ICM) influences post-transfer embryonic survival and development of the embryo-proper and fetus. Four replicates of slaughterhouse-derived cumulus oocyte complexes underwent in vitro maturation and …
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Supplementing Bovine Embryo Culture Media to Improve the Production and Quality of In Vitro Produced Bovine Embryos
… in this work explored the role of interleukin-6 (IL6) and leukemia inhibitory factor (LIF) in preimplantation bovine embryos. Neither cytokine affected the total percentage of embryos which developed to the blastocyst stage in vitro. However, supplementation of IL6 increased blastocyst inner cell …
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Interleukin-6 and its Contribution to Embryogenesis in Cattle
… this by supplementing a cytokine, interleukin-6 (IL6), during in vitro embryo culture. My dissertation work expands upon those initial efforts by answering more detailed questions related to the biological role of IL6 during cattle embryogenesis. In the work presented herein, IL6 supplementation …
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Role of AID and microRNA-155 in c-myc-IgH Translocations
… we searched for such events in both IL6 transgenic (IL6 tg) and AID-/- IL6 tg mice. Our experiments demonstrate that AID is required for c-myc to Ig V-JH translocations induced by IL6. We also investigated the potential role of microRNAs (miRNAs) in AID mediated processes. MiRNAs are …
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Biomarkers of Physiological Damage and their Potential for Work-Related Musculoskeletal Disorder Risk Assessment
… Oligomeric Matrix Protein (COMP), Interleukin-6 (IL6), and Creatine Kinase (CK). First, the effects of age, obesity, gender, and diurnal variation was investigated. Significant effects of time, age, and gender were evident, as well as some interactive effects, for COMP and CK, but not IL6. Second, …
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Methamphetamine, interleukin-6 and perineuronal nets in synaptic plasticity
… lipid peroxidation mechanisms. Interleukin-6 (IL6) is a pleiotropic cytokine that is a mediator of immune and inflammatory processes. IL6 is known to mediate METH-induced neurotoxicity. We used mice models to test a combination of a clinical dose of METH and IL6 deficiency on learning and …
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Vergleich der Genexpression im entzündlichen Kolonepithel und im kolorektalen Karzinom im Hinblick auf das erhöhte Tumorrisiko bei chronisch entzündlichen Darmerkrankungen
… Die Ergebnisse der RNA-Expression von COX-2 und IL6 bestätigen deren wichtige Funktion bei Entzündungen und der Entstehung von Tumoren auch im Kolonepithel: Die COX-2- und IL6-RNA-Expression ist in der CU- und in der Tumorgruppe im Vergleich zur Normalgruppe signifikant erhöht. Der IL6-RNA-Gehalt …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
… factor nuclear factor for interleukin 6 (NF-IL6), a robust biomarker for tracking neuroinflammation in glial cells. Inflammation was confirmed by measuring the concentrations of pro-inflammatory cytokines IL-6 and TNF-α released by OBSCs in the culture medium. Lastly, we used single-nucleus …
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Immunomodulation of commercial line and Piau Brazilian Naturalized breed pigs in response to vaccination against Mycoplasma hyopneumoniae and Pasteurella multocida type D
… para TLR2, TLR4, TLR6 e TLR10 e as citocinas IL6 e TNFα depois da vacinação que antes da vacinação, enquanto os animais da raça Piau mostraram maior expressão para TLR6, TLR10, TNFα e TGFβ. Em relação às amostras de BALF, os animais vacinados da raça Piau tiveram maior diferença de expressão …
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The neuroimmune response to cryptococcal infection
… of nuclear factor for interleukin 6 (NF-IL6), and confirmed by measuring the release of IL6 and tumour necrosis factor- (TNF-α). Our results showed that neither C. neoformans nor its purified capsule elicited a neuroinflammatory response as observed in LPS-treated slices. Co-stimulation …
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Role Of Crebh In Endotoxin Mediated Modulation Of Hepatic Metabolism
… signals. Proinflammatory cytokines TNFα, IL6, and IL1β, bacterial endotoxin lipopolysaccharide, insulin signal, saturated fatty acids, nutrient starvation, or atherogenic high-fat (AHF) feeding, can all induce expression and/or activation of CREBH in the liver. In this study, we …
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Host-intrinsic factors determine anti-tumor efficacy of exercise in pancreatic ductal adenocarcinoma
… muscle actin (αSMA<sup>+</sup>) cells and <em>Il6</em> expressing inflammatory cancer associated fibroblasts (iCAFs). Similar analysis of tumors from patients in the PancFit trial demonstrated an exercise induced reduction in αSMA<sup>+</sup> cells. We subsequently identified Cholic Acid (CA), …
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