Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IL3"”.
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GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA
… cell secreting factors, such as Interleukin 3 (IL3) hinder TKI activity and support CML–LSCs to survive the therapy with innate drug resistance. Therefore, the overall objective of this work was to target IL3 receptor as the biomarker of LSCs in CML. We generated anti–IL3Rα and anti–IL3Rβ …
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Mutational Analysis to Define the Functional Role of the Third Intracellular Loop of D1-Class Dopaminergic Receptors
The third intracellular loop (IL3) and cytoplasmic tail (CT), which are the most divergent regions between human D1-class dopaminergic receptors (hD1R and hD5R), have been implicated in modulating their subtype-specific functional phenotypes. The importance of the IL3 for Guanine nucleotide-binding …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… resting state is the infectious third larval (iL3) stage, and activation of the receptor in iL3 worms outside of the host induces a premature and lethal molt (Wang et al. 2009; Motola et al. 2006). In contrast, the relatively uncontrolled soybean parasite Heterodera glycines, which causes USD 1 …
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DAF-12: A Novel Drug Target in Parasitic Nematodes
… resting state is the infectious third larval (iL3) stage, and activation of the receptor in iL3 worms outside of the host induces a premature and lethal molt (Wang et al. 2009; Motola et al. 2006). In contrast, the relatively uncontrolled soybean parasite Heterodera glycines, which causes USD 1 …
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The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis
… asked whether the combined absence of IL-4 and IL3, as compared to IL-4 deficiency only, would increase resistance to an aerogenic Mycobacterium tuberculosis infection. By using IL-4 gene-deficient mice, it was confirmed that endogenous IL-4 does not reduce host immunity. In contrast, IL-4Rα …
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Nuclear Receptor Controls Nematode Metabolism And Development: Insight Into Man’s Nemesis, the Conqueror Worm
… also induced recovery from the infective L3 (iL3), which is the dauer larva of the parasites. Moreover, the metabolic genes controlled by C. elegans DAF-12 were identified in parasitic nematodes. These facts indicate that the DAF-12 signaling pathway is conserved in parasitic nematodes. …