Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IL21"”.
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
… K562 expressing membrane bound IL-21 (K562.mbIL21), and showed that K562.mbIL21 enables significantly higher expansion of functionally potent NK cells compared to K562.mbIL15. Both membrane bound IL15 (mbIL15) and membrane bound IL21 (mbIL21) expanded NK cells are currently in several Phase …
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STEPWISE DIFFERENTIATION OF IL21-PRODUCING FOLLICULAR HELPER T CELLS REVEALS DISTINCT DEVELOPMENTAL AND FUNCTIONAL STATES
… Tfh cells. Through selective in vivo deletion of IL21-experienced Tfh cells, we show that these subsets control antigen-specific germinal center formation, maintenance and somatic hypermutation at distinct stages of the germinal center response to a SARS-CoV-2 protein vaccine. Together, these …
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… IL17A/F locus as well as to regions in the IL17, IL21 and IL22 promoters. Using bio-computational methods we determined that the Batf-binding element in the IL17, IL21 and IL22 promoters differs from canonical symmetric AP-1 elements. Using EMSA analysis we found that Batf forms heterodimers …
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Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
… of the association to the region comprising IL2/IL21 genes on 4q27, reported in the first genome-wide association study (GWAS) in celiac cases and controls. We confirmed that the IL2/IL21 region is a susceptibility region in CD. Unfortunately, the first GWAS failed to identify specific genes …
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Análise transcritômica de linfócitos T humanos tratados com anticorpos anti-CD3
… foram induzidas por todos os tratamentos. Porém, IL21 e IL22 foram regulados positivamente somente em OKT3. Embora os anticorpos anti-Cd3 humanizados apresentaram um efeito imunomodulatório, mais estudos são necessários para compreender os mecanismos envolvidos nessa imunomodulação.
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Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
… upregulation of the TFH associated genes Bcl6, Il21, and Icos, correlating with increased B cell helper activity. Conversely, exposure of these TFH-like cells to IL-7 results in the STAT5-dependent repression of Bcl-6 and subsequent inhibition of the TFH phenotype. Finally, we describe a novel …