Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"IL2"”.
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Rationale Ansätze zur Prozessentwicklung eines Anti-EGF-IL2-Fusionsproteins mittels einer rekombinanten BHK-Zelllinie
… strategy for the production of an anti-EGFR-IL2-fusionprotein with a recombinant baby hamster kidney cell line (BHK). The thesis is integrated within a cooperation project with MERCK KGaA, Darmstadt. The classical process development part includes the investigation of process parameters …
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Precision Cytokine Therapy: Engineering and Delivery of CD8- and CAR-Tropic Interleukin-2 Variants
… expressing modified versions of interleukin 2 (IL2), a key T cell growth factor, using an adeno-associated viral (AAV) gene delivery system. Previous work by Yshii et al. (2022) demonstrated that AAV-mediated expression of wild type IL2 in the brain expanded immunosuppressive CD4+ regulatory T …
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Stress-induced remodeling of the caenorhabditis elegans dauer
… dauer stage of Caenorhabditis elegans, the IL2 neurons arborize to cover the anterior body wall. In contrast, the FLP neurons arborize to cover an identical receptive field in favorable conditions. How coordinated branching is established between these two neuronal subtypes is unknown. …
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Novel Tools for Investigating Microglia Cellular Turnover Kinetics and Microglia-CD4 T Cell Interaction
… 2022) using a novel adeno-associated virus (AAV)-IL2 delivery system to increase IL2 concentrations locally in the brain to stimulate Treg proliferation. In the context of traumatic brain injury, in preclinical mouse models AAV-IL2 delivery drove a Treg-dependent modification of microglia activity …
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Transmedia storytelling in the portuguese context of english as a second language learning
… o ensino de Inglês como segunda língua (IL2) é orientado pelo cumprimento de metas e temáticas propostas no currículo nacional. Esta estrutura dogmática não permite explorar a utilização que os alunos fazem da língua nos seus contextos informais e exclui oportunidades de aprendizagem que …
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The antitumor activity of tumor-targeted RNA replicase-based plasmid DNA
… plasmid by incorporating interleukin-2 (IL2) gene into the plasmid was investigated. The resultant pSIN-IL2 plasmid was delivered to mouse melanoma cells that over-express the sigma receptor. The pSIN-IL2 plasmid was more effective at controlling the growth of B16 melanoma in mice when …
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Modifying the lung microenvironment through gene delivery of immunomodulatory cytokines
… I focused on delivering Interleukin 2 (IL2), Interleukin 10 (IL10), and Interleukin-1 receptor antagonist (IL1ra) to the lung and evaluated their impact on respiratory disease models including acute lung injuries caused by influenza and lipopolysaccharides (LPS), as well as chronic lung …
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
… thymidine kinase (HS-tk), human interleukin 2 (IL2). and B-galactosidase (BAG) genes. Each osteosarcoma cell line was stably transduced, and the HS-tk gene effectively conferred ganciclovir (GCV) susceptibility to transduced cells. Each cell line showed a bystander effect (whereby wild type …
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Combinatorial strategy to generate antibody-cytokine fusions with "activity-on-demand" for cancer therapy
… (TNF), interleukin 12 (IL12), and interleukin 2 (IL2) have shown substantially improved anti-cancer efficacy. However, they typically retain full cytokine activity and may cause toxicities at early time points after intravenous administration, comparable to the naked payload at equivalent doses. …
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Generation and in vivo validation of multi-functional antibody-fusion proteins for cancer therapy
… most malignancies. Immunocytokines such as L19-IL2, L19-TNF and L19-IL12 are showing promising results in the clinic for the treatment of progressive solid tumors, including sarcoma, melanoma, renal cell carcinoma and glioblastoma. In this work, I contributed to the generation and preclinical …
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Phänotypische und funktionelle Charakterisierung von CD4+CD25+ "regulatorischen" T-Zellen aus dem Nabelschnurblut
… CD4+CD25+-Zellen und CBMC wurden jeweils mit IL2 (und Medium alleine als negativ Kontrolle) in Kultur gesetzt. Nach 7 Tagen wurde die Proliferation der Zellen mittels 3H-Thymidin/Szintillation gemesssen. Für die Zytokin-Analyse wurden CBMC oder CBMC/CD4+CD25+-Kokulturen mit Medium alleine oder …
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Evolve : a preliminary multicore architecture for Introspective Computing
… and the Introspective L2 Memory System (IL2). The branch predictor employs a partner core as a coprocessor engine for general dynamic branch prediction in a corresponding code core. The IL2 retasks the silicon resources of partner cores as banks of an on-chip, distributed, software L2 …
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Einfluss atopischer Prädisposition auf allergenspezifische Proliferation und Zytokinprofile maternaler und fetaler mononukleärer Blutzellen
… der Proliferation (25.000 Zellen/well) wurde mit IL2 (Positivkontrolle, 5IU/well), BLG (25mg/ml), OVA (25mg/ml), und Derp (10mg/ml) stimuliert, der Einbau von tritiummarkiertem Thymidin wurde im Betacounter gemessen. Bei der Zytokinbestimmung (100.000 Zellen/well) wurden PHA (20mg/ml) und BLG …
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The actin-binding protein Drebrin and its implications for Alzheimer's Disease using the model organism C. elegans
… of head neurons of the anterior ganglion, the IL2 neurons, exhibits the first aggregates and that a cell-type specific suppression of Aβ(1-42) in IL2 neurons could delay the disease onset. Drebrin was observed to be regulated by phosphorylation at Serine-647 by Ataxia telangiectasia mutated …
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Cytokine-capture nanoparticles to quantify IL-2 concentrations within the immunological synapse during T cell activation
… have shown successful detection of exogenous IL2. A comparison of existing patents with cytokine-capture technology revealed that although each aspect of the device is covered by prior IP, the capabilities of the technology exceed the claimed uses of the individual components. A preliminary …
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An evaluation of cytokine-capture nanoparticle technology : stepping from bench-space into potential markets
… have shown successful detection of exogenous IL2. A comparison of existing patents with cytokine-capture technology revealed that although each aspect of the device is covered by prior IP, the capabilities of the technology exceed the claimed uses of the individual components. A preliminary …
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Immunomodulation of commercial line and Piau Brazilian Naturalized breed pigs in response to vaccination against Mycoplasma hyopneumoniae and Pasteurella multocida type D
… para os genes TLR2, TLR4, TLR6, TLR10, IL2, IL6, IL8, IL10, IL12, IL13 e TNFα entre os tempos estudados, após duas doses da vacina; enquanto os animais Piau tiveram somente diferença de expressão para a citocina antiinflamatória TGFβ. Para expressão gênica em células de BALF dos animais …
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Bedeutung des löslichen CD14-Rezeptors in Plasma und Urin als immunologischer Parameter nach Nierentransplantation und sein Verhältnis zu den löslichen Rezeptoren IL2R, CD4 und CD8
… untersucht. Weiterhin werden der lösliche IL2-Rezeptor (sIL2R), der lösliche CD4 (sCD4) und der lösliche CD-8 (sCD8) ins Verhältnis mit dem sCD14 gesetzt. Es zeigt sich, dass sich die Plasmakonzentrationen des sCD14 bei Abstoßung und Infektion signifikant gegenüber einer stabilen Tx …
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Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
… of the association to the region comprising IL2/IL21 genes on 4q27, reported in the first genome-wide association study (GWAS) in celiac cases and controls. We confirmed that the IL2/IL21 region is a susceptibility region in CD. Unfortunately, the first GWAS failed to identify specific genes …
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