Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"IL15"”.
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Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… in C57BL/6 wild-type (WT), IL-15 deficient (Il15-/-) and IL-15R[alpha] deficient (Il15ra-/-) mice. After 7 days, macromorphological analysis of the small and large intestine of Il15 null mice did not reveal any spontaneous abnormalities when compared to WT littermates. To determine the impact …
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Immunotherapy for murine glioma
… of gliomas. An oncolytic virus encoding IL15Ra-IL15 (the T cell activating stimulus) and the prostaglandin synthesis inhibitor celecoxib (the anti-immunosuppressant) were combined with adoptive transfer of tumor-specific T cells. Two oncolytic poxviruses, vvDD vaccinia virus and myxoma …
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
… engineering a new recombinant myxoma virus (vMyx-IL15Rα-tdTr), which expresses an IL15Rα-IL15 fusion protein as well as tdTomato red fluorescent reporter protein, and the antitumor effect of the virus. Interleukin-15 (IL15) is an immunomodulatory cytokine with significant potential for stimulating …
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Engineering cytokine immunotherapies via cell surface targeting
… CD45. First, we engineer and profile an αCD45-IL15 fusion that exhibits significantly diminished receptor-mediated internalization relative to its wild-type counterpart. This extended surface half-life augments downstream pSTAT5 induction and enables both cis and trans signaling between …
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Signaling pathways regulating skeletal muscle metabolism and growth
… potentially through epigenetic regulation of Il15 by OGT. To further investigate if there was a causal relationship between OGT ablation and the lean phenotype, we generated muscle specific OGT and interleukin-15 receptor alpha (IL-15ra) double knockout mice (mDKO). As a result, mDKO mice had …
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
… functionally potent NK cells compared to K562.mbIL15. Both membrane bound IL15 (mbIL15) and membrane bound IL21 (mbIL21) expanded NK cells are currently in several Phase I/II clinical trials. K562.mbIL21 surpasses any other expansion to date not only in its rate of NK cell expansion, but also …
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Enhancement of Hiv Persistence By Adipose Tissue
… common gamma-chain cytokines, IL2, IL7, or IL15. Adipocytes further enhanced T cell viability and even mitigated the viral suppressive effects of some antiretroviral drugs. To determine if adipose depots are sites for HIV persistence in vivo, adipose tissues of infected humans and rhesus …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… OP9 bone marrow stromal cells in the presence of IL15, IL7, FMS-like tyrosine kinase 3 ligand: Flt3L) and stem cell factor: SCF). Flow cytometry results showed NK1.1<super>&plus</super> cells emerged after at least 7 days in culture. By using limiting dilution analysis, we demonstrated a cell …
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Modulating Immunometabolism to Improve The Activity of Car-Nk Cells Targeting Cd70 In Renal Cell Carcinoma
… any potential safety concerns (iC9/CAR.CD70/IL15).</p> <p>However, the translation of CAR-based therapies to solid tumors is still associated with many challenges. Some of these obstacles include trafficking and penetration of NK cells to tumor sites, the persistence of infused NK cells, the …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… progesterone-regulated genes (FOXO1, HAND2, IL15, IGFBP1, HOXA10, 17ßHSD2 and FOXM1). Immunohistochemistry evaluated spatiotemporal immunolocalisation, on a selection of samples, of sex steroid receptors (PR, PRB, ERα, AR) as well as Ki67, 17ßHSD2, and HOXA10 in AUB-L, AUB-A, AUB-L&A, and …