Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"IL-9"”.
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The Impact of IL-9 on Disease in Murine Models of Systemic Lupus Erythematosus
… SLE patients has been shown to have elevated CD4+IL-9+ T cells as well as increased secreted IL-9 and Il9 mRNA compared to healthy controls. In other antibody mediated autoimmune models, such as rheumatoid arthritis, type II innate lymphoid cells (ILC2s) secrete increased IL-9 to promote the …
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TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma
The TNF superfamily member TL1A is a costimulatory molecule that signals through its receptor DR3 on T lymphocytes. The Th9 subset of T lymphocytes secretes the pleiotropic cytokine IL-9 which has functions in allergic airway disease, helminth infections, and tumor immunity. TL1A increases IL-9 …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… T helper 9 (Th9) cells, derived by the IL-4/STAT6 and TGF-β signaling pathways, produce IL-9 as a hallmark cytokine, as well as IL-10. Through IL-9 production, Th9 cells protect against parasite infection but are also involved in allergic inflammation and autoimmune diseases. …
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The role of IL-4 and Th2-like cytokines in pulmonary tuberculosis
… associated with protection, many individuals still have progressive active TB. Whether a Th2-like immune response (IL-4; IL-4δ2; IL-9) can subvert protective host immunity requires clarification.
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
… T<sub>H</sub>2-specific cytokines (<em>i.e. </em>IL-4, IL-5, IL-9 and IL-13), increased airway eosinophilia, and mucin hypersecretion. Although there are several therapeutics currently treating asthmatic patients, some of these treatments can result in drug tolerance and may be linked to increased …
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The roles of Cabin1 and Left1 in T cell development
… mice switched to IgG 1 at the same frequency as wildtype B cells in vitro in the presence of IL-4. However, in response to anti-CD3 stimulation, mutant T cells expressed significantly higher levels of IL-2, IL-4, IL-9, IL-13, and IFN-y. Thus, the calcineurin and MEF2 binding domain of Cabin 1 is …
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Mast cells in gastrointestinal helminth infection
… cell-deficient (Wsh) mice, as these mice are fertile and not anaemic. Similar to previous studies using W/Wv mice, it is found that Wsh mice are impaired in their ability to expel these parasites, but not as significantly as was observed in W/Wv mice. Therefore, mast cells may contribute to worm …
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Developing In Vitro and In Vivo Models for Lyme Neuroborreliosis (LNB)
… of cytokines such as TNF-alpha, IFN-γ, and IL-9 and reduction in microglia in the infected mice. Lastly, we demonstrated that C. elegans can feed on B. burgdorferi, which may result in neurodegeneration. This provides a powerful tool for screening pathogen and host factors involved in …
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Transcription factor regulation of T helper subset function
… and B cells are integral components of the ability of the immune system to generate focused immune responses. The development of specialized subsets of T helper cells is governed by transcription factors. Previous work demonstrated a requirement for the transcription factor PU.1 in the …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… because of their functional plasticity and ability to respond to environmental cues. Classically activated M1 macrophages promote inflammation through cytokines such as IL-1β, IL-6, and TNF-α, whereas alternatively activated M2 macrophages support immune regulation and tissue repair processes. …
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Advancing Clinical Remission in Severe Asthma: Efficacy of a Comprehensive Management Strategy Guided by Airway Inflammometry and Bioimaging [Migliorare la remissione clinica nell'asma grave: Efficacia di una strategia di gestione completa guidata dall'infiammometria delle vie aeree e dal bioimaging]
… composito nell'asma grave. Tuttavia, solo circa il 30% dei pazienti raggiunge la remissione clinica quando le decisioni terapeutiche sono guidate dai livelli di eosinofili ematici e FeNO. Obiettivi: Valutare l'efficacia di una strategia terapeutica individualizzata e comprensiva nel raggiungere …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… they produce. Very limited information is available about the regulation of cytokine production in this array of Th2 cells. We have recently identified the ETS family transcription factor PU.1 as regulating heterogeneity in Th2 populations. To define additional factors that might contribute to …
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Localizzazione della topoisomerasi IB sui telomeri di S. cerevisiae e ruolo della sua attività catalitica sulle modificazioni istoniche
Il superavvolgimento del DNA nelle cellule, regolato dalle DNA Topoisomerasi, influenza molti processi biologici, quali la trascrizione, la replicazione, la ricombinazione ed il rimodellamento della cromatina. La DNA Topoisomerasi IB eucariotica, (Top1), è un enzima efficiente nella rimozione dei …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… of most of the Toll-like receptor (TLR) family and all the IL-1 receptor family members. Activation of MyD88 dependent signalling is critical for the immune response during infections, however dysregulation of these pathways can contribute to the development of immune mediated …
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Trichuris Muris Whey Acidic Protein Induces Type 2 Protective Immunity Against Whipworm
… antigen-specific production of TH2 cytokines IL-4, IL-9, and IL-13 by cells isolated from the vaccine-draining inguinal lymph nodes, parasite-draining mesenteric lymph nodes, and spleen in mice vaccinated with either r<em>Tm</em>-WAP49 or r<em>Tm</em>-WAP-F8+<em>Na</em>-GST-1. The humoral …
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Characterization of Skin Immune Reactions Induced by the Contact Sensitizer Diphencyprone in Healthy Volunteers and Metastatic Melanoma Patients
… be anti-neoplastic effectors, including IFNγ, IL-24, and IL-9. We also examined the potential roles of miRNAs in skin reactions to DPCP, as they may be involved in its therapeutic applications, but are largely unstudied in skin biology and immunology. Furthermore, we used comprehensive T cell …
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T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
… cells, including mast cells, eosinophils, neutrophils, and lymphocytes, are critical in the initiation of the pathophysiological changes in asthma. The mobilization and recruitment of these inflammatory cells are primarily due to the release of proinflammatory cytokines (IL-4, IL-5, …