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Showing 1 to 20 of 239 for “"IL-8"”.
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Response of salivary IL-8 to prolonged and interrupted sitting
… on inflammation, as determined by cytokine profiles, is relatively unexplored. The purpose of this work was to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: prolonged sitting …
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Understanding the role of interleukin-8 (IL-8) in canine osteosarcoma metastasis
The student, Matthew Dowling, accepted the attached license on 2018-06-20 at 22:06.
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Neue Normwerte für ACE, sIL-2R, Lysozym und IL-8 in der Sarkoidose-Diagnostik
… vorliegende Arbeit war, neue Normwerte für ACE, sIL-2R, Lysozym und IL-8 in der Sarkoidose-Diagnostik zu liefern. Bevorzugt sollten mittels ROC-Analysen Cut-off-Werte erstellt werden. METHODIK: Bei 66 Sarkoidosepatienten und 46 Patienten mit fibrosierender interstiteller Lungenerkrankung und einer …
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Nfat1 Contributes to Melanoma Tumor Growth and Metastasis By Regulating Il-8 and Mmp-3
… role of NFAT1 in melanoma progression we stably silenced NFAT1 expression in the highly metastatic cell line, A375SM, and subjected the cells to gene expression microarray analysis. We identified and validated two downstream targets of NFAT1, i.e; IL-8 and MMP-3 to be downregulated following …
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
Control of mRNA stability is an important aspect in the regulation of gene expression. A well studied signal for rapid transcript decay in mammalian cells is the AU-rich element (ARE), which is found in the 3’ untranslated region (UTR) of many labile transcripts. These sequence elements confer …
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The Role of Il-8-Mediated Src Family Kinase Activation In Tumor-Tumor and Tumor-Stromal Interactions In Metastasis of Prostate Cancer
… of protein tyrosine kinases, including Src Family Kinases (SFKs) contribute to metastasis through numerous functions, one of which leads to increased expression of cytokines, such as IL-8. However, the relationship between Src activity and IL-8 regulation is not completely understood. In cell …
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Untersuchungen zur Rolle von organischen Stäuben in der Pathogenese der exogen-allergischen Alveolitis
… in der Akutphase der Erkrankung zu einer neutrophilen Alveolitis. In der Lavageflüssigkeit dieser Patienten fanden sich im Vergleich zu gesunden Normalpersonen erhöhte Spiegel an IL-8. Die Lavageflüssigkeit hatte eine verstärkte chemotaktische Aktivität gegenüber PMNs im Vergleich zur …
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Cattle feedlot dust: Solubility in lung simulant fluid and stimulation of cytokine release from lung epithelial cells
… system. This lead to focusing on solubility of dust in lung simulant fluid, and in-vitro study of release of two common biomarkers of inflammatory processes IL-6 and IL-8 from lung epithelial cells. Various concentrations (1 to 50%) of the dust extract induced release of IL-6, and IL-8 …
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Die Bedeutung leukozytärer Subpopulationen für die Arteriogenese im Kaninchenhinterlauf
… jedoch nicht nur auf Monozyten, und die Beteiligung anderer Leukozytensubpopulationen mit bekannter Bedeutung für das Kapillarwachstum (Angiogenese) in der Arteriogenese ist weitgehend unklar. In dieser Studie untersuchten wir den Einfluss von Granulozyten- und Lymphozytenchemoattraktion und …
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Local Inflammatory Responses in Pseudomyxoma Peritonei
… specimens were immunostained for interleukin 6 (IL-6), interleukin 8 (IL-8), interferon inducible protein 10 (IP-10) and monocyte chemotactic protein 1 (MCP-1). Effects of IL-6 and IL-8 on cell growth were determined using recombinant human cytokines and the human mucinous colorectal cell line, …
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<i>Haemophilus influenzae</i> modulins in chronic obstructive pulmonary disease airway inflammation
… cells, leading to the production of interleukin (IL)-8. We exposed human tracheal epithelial cells to H. <em>influenzae</em> strain Rd and compared the resulting profiles of IL-8 secretion. Putative H. <em>influenzae</em> Rd modulins were enriched from culture supernatant fluid. Proteome analysis …
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Development of monoclonal antibody cell culture processes and antibody characterisation
… A CHO-DP12 cell line engineered for anti-IL-8 mAb expression and a cNIST mAb-producing CHO cell line were employed to investigate key cell culture process parameters. Upstream studies examined the effects of media formulations and seeding density studies on antibody expression. While …
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The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
… associated neurocognitive disorders (HAND) still persist and affect about half of the HIV infected population. The importance of HIV-1 accessory protein Vpr has been well established in the pathology of AIDS in the peripheral and central nervous system. However, the role of Vpr in …
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Role of interleukin-8 monomer-dimer equilibrium and glycosaminoglycan interactions in neutrophil recruitment
… for recruiting target cells. Interleukin-8 (IL-8) is a proinflammatory chemokine, recruits neutrophils as a host response to infection and tissue injury.. An imbalance in the recruitment process has been attributed to a variety of autoimmune and inflammatory diseases. Knowledge of in vivo …
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Spezifische Zytokinmuster und Schrankenstörung bei interstitiellen Lungenkrankheiten
… Schwerpunkt der Untersuchungen bezogen sich auf IL-2 Rezeptor, IL-8 und Lysozym in bronchoalveolaerer Lavagefluessigkeit (BALF) und Serum bei Patienten mit Sarkoidose, Exogen-allergischer Alveolitis (EAA) und interstitieller Lungenfibrose (IPF). Unbehandelte Sarkoidosepatienten hatten über den …
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Inhibition of Monocyte Chemotaxis and Chemokine Macrophage Inflammatory Protein-1 Alpha, and Interleukin-8 Secretion by Lipopolysaccharide Isolated from Periodontal Pathogens
… protein 1‑alpha (MIP‑1α) and interleukin 8 (IL‑8) both of which have been characterized as potent monocyte chemoattractants. IL‑8 has potency as a chemotactic agent equal to that of C5a. It is a pro-inflammatory mediator of gingivitis and a mediator of the inflammatory response, by serving as …
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Analysis of biological pathways, associated with orthodontic force, using multiplex arrays
… Crevicular Fluid (GCF), was collected from maxillary canines and second molars from volunteers (n=21), before appliance placement and tooth extraction (B); 3 months into orthodontic treatment (T1); at 4 hours (T2); 1 week (T3); and 6 weeks (T4) after application of a canine distalising force. …
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The structural basis of chemokine binding affinity and receptor selectivity: Role of receptor N-terminal domain
… structural basis of interaction of chemokines, IL-8 and MGSA monomers and dimers with their receptors CXCR1 and CXCR2. CXCR1 is specific and binds IL-8 alone with high affinity, whereas CXCR2 is promiscuous and binds both ligands with high affinity. The receptor structures are not known, and …
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Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma
Trauma is a leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is falling from less than 2 meters, with the primary …
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Intestinal Inflammatory Responses to the Indigenous Microbiota
… evaluated in HT-29 cells associated with Lactobacillus plantarum 299v in the presence or absence of tumor necrosis factor-alpha (TNF-alpha). Co-culture of TNF-alpha-stimulated HT-29 cells with L. plantarum 299v increased interleukin-8. (IL-8) mRNA expression above levels observed for cells treated …
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