Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"IL-7"”.
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The Role of Hspa9 in Mouse Hematopoiesis and IL-7 Receptor Signaling
… pathways as the most down-regulated pathways. IL-7 added exogenously to CFU-PreB cultures was able to partially rescue the reduction in Hspa9+/- CFU-PreB colony formation, further indicating dysfunctional IL-7 signaling in Hspa9+/- B-cells.</p><p>To explore the contribution of Hspa9 to altered …
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Comparative Studies of TSLP and IL-7 in Normal Early Human Neonatal and Adult B Cell Development
… this study was to investigate the roles of the IL-7R ligands, thymic stromal lymphopoietin (TSLP) and IL- 7, in the early stages of normal postnatal and adult human B cell development. Using novel in vitro and in vivo model systems, we show that TSLP and IL-7 are able to expand B cell precursors …
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Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… intrinsic heterogeneity in the TCR-independent abilities of CD8⁺ T-cells to respond to homeostatic ye cytokines, and survive in their absence. These differences were predictably marked by expression of CD5, a surrogate marker of TCR:spMHC binding avidity. In vitro, CD5I T-cells proliferate more …
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Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
… CD4+ levels, however, 5-20% of patients fail to reconstitute CD4+ T cell levels despite viral suppression. Interluekin-7 (IL-7), a homeostatic cytokine, increases proliferation and survival of memory T cells. It is also a candidate immune therapeutic to assist CD4+ T cell recovery following …
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A multiomic study to unveil the salt stress tolerance mechanisms in S. pennellii x S. lycopersicum Introgression Lines (ILs) [Uno studio multiomico per svelare i meccanismi di tolleranza allo stress salino nelle linee di introgressione (ILs) di S. pennellii x S. lycopersicum]
… sul metabolismo delle piante, portando a uno sviluppo ridotto, a una riduzione della produzione e, infine, alla morte della pianta stessa. Molte colture hanno numerosi “parenti selvatici”, capaci di crescere in condizioni subottimali. Solanum pennellii, una specie selvatica di pomodoro endemica …
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Mutational Analysis of CD127 and Its Role in Immunological Diseases
Interleukin (IL) -7 is an essential non-redundant cytokine that influences T-cell differentiation, proliferation, homeostasis and T-cell functions. In T-cells, IL-7 signals are transduced via IL-7's heterodimeric receptor composed of a common, γ chain (CD132) and an IL-7 specific, α chain (CD127). …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… peptide presented on class-I major histocompability complex (MHC-I) molecules. The second signal is delivered via the co-stimulatory receptors upon recognition of their ligands on antigen presenting cells. However, in response to homeostatic pressure, as in lymphopenia, naive T cells undergo …
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L’UTILIZZO DEL VERDE DI INDOCIANINA NELLA PREVENZIONE DEL LEAK ANASTOMOTICO IN CHIRURGIA COLO-RETTALE
Il leak anastomotico nella chirurgia colorettale è ancora un problema reale nonostante i progressi tecnologici e di tecnica in chirurgia. L'incidenza del Leak anastomotico è stimata tra il 7 ed il 15%. I difetti di perfusione colica e anastomotica rappresentano la causa più importante di leak …
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Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in Humans and In Vitro differences between genetically stratified subjects based on Interleukin-7 Receptor Genotype
… before allowing lymphocyte reconstitution. IL-7Rα was identified by genetic studies in MS pathogenesis and is involved in the homeostasis and proliferation of lymphocytes. This thesis investigates the role of antagonism of IL-7Rα in the treatment of MS in humans and in vitro differences …
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Effect of HIV infection and pregnancy on parameters of vaginal immunity
… pathway that has been implicated in susceptibility to HIV infection, and two interferon pathways that have been associated with antiviral immune defense. We hypothesized that pregnant women have increased proinflammatory cytokines in genital secretions, potentially putting them at increased …
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Comparison of HIV-1 specific T cell immunity in the female genital tract and blood of HIV-infected women : impact of in vitro T cell expansion on HIV-specific T cell specificity, maturational status and functional complexity
… approach to increase the number of T cells available from mucosal sites. Dynal beads (1:1) in the presence of IL-2, IL-7 and IL-15 resulted in the best yields of cervical T cells while anti-CD3 in the presence of IL-2 best conserved the ex vivo T cell profile. Expanded T cell lines, …
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Development of a hydrogel-based microfluidic model of the lymph node
… in response to tumour drainage that is still partly unclear. In vivo models do not easily permit us to follow events longitudinally or to manipulate the environment, while currently there is a lack of in vitro platforms that recapitulate the LN complexity to study its role in response to …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… encoding a GTP exchange factor for the Rac family of cytoplasmic small G proteins, which has previously been found to be critical for T cells and immunity in mice and humans. The second mutation was a synonymous exonic nucleotide substitution in Senp2, encoding a specific protease for cleaving …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… encoding a GTP exchange factor for the Rac family of cytoplasmic small G proteins, which has previously been found to be critical for T cells and immunity in mice and humans. The second mutation was a synonymous exonic nucleotide substitution in Senp2, encoding a specific protease for cleaving …
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Analyses of hematopoiesis and lineage commitment from ES and iPS cells
… iPS-Zelllinien, die sich durch die Anzahl der gebildeten erythroiden, lymphoiden und myeloiden Zellen bestimmen ließen. Es war erwartet worden, dass iPS-Zellen, die aus hämatopoietischen Knochenmarkzellen durch ektopische Expression von Sox-2, Oct-4 und Klf-4 generiert worden waren, aufgrund ihres …
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Impact of Leucine and HMB on Acute Muscle Damage: Focus on Repair and Regeneration in vivo and in vitro
… is limited. Therefore, the aim was to utilise amino acid supplementation as an intervention to reduce damage and/or facilitate growth and repair in skeletal muscle using in vivo and in vitro models. Methods: Three models were used to investigate these processes: 1) strenuous eccentric …
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Curcumin as a therapeutic agent for the treatment of rheumatoid arthritis and cancer
… efficacy of curcumin as a therapeutic agent whilst identifying potential therapeutic biomarkers for the treatment of these inflammatory conditions. HFLS-RA cells were treated with curcumin and MTX, individually and in combination. The novel finding from this study highlighted that individual …
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Can curcuminoids be more effective than sulfasalazine for the treatment of rheumatoid arthritis?
Rheumatoid Arthritis (RA) is a debilitating, chronic autoimmune disease leading to progressive joint destruction. Current treatment includes methotrexate and sulfasalazine, however, side effects and tolerability are major limitations. Curcumin is a natural polyphenol obtained from Curcuma Longa …
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Combined chemotherapy and immunotherapy against experimental malignant brain tumors
… such as interferon-gamma (IFNγ), interleukin-7 (IL-7) and granulocyte macrophage-colony stimulating factor (GM-CSF). In the N32 rat glioma model there is a synergistic therapeutic effect when combining immunization with IFNγ- and- IL7-producing tumor cells and this coincides with enhanced …
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