Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"IL-6R alpha"”.
-
Entwicklung und Charakterisierung eines IL-6-Inhibitors basierend auf Funktionsanalysen des murinen IL-6R alpha
… and induce a multitude of biological effects. IL-6-type cytokine family members activate the Jak/STAT signalling pathway and hence modulate processes such as apoptosis, proliferation, angiogenesis and migration of cells. The cytokine IL-6 possesses great clinical relevance because dysregulation …
-
Untersuchungen zur Rolle von Neurozytokinen in Hirntumoren
Ciliary Neurotrophic Factor (CNTF) and Interleukin-6 (IL-6) influence the survival and the differentiation of neuronal and glial cells. CNTF induces reactive transformation of astrocytes in vivo and has been shown to promote proliferation of neuronal tumor cell lines in vitro. Thus, CNTF is a …
-
Herstellung und Charakterisierung hochaffiner Inhibitoren für die Zytokine IL-6 und LIF basierend auf den Liganden-bindenden Domänen ihrer Rezeptor-Untereinheiten
… progression of different diseases. Dysregulated IL-6 production can lead to chronic inflammatory diseases like rheumatoid arthritis or to different types of cancer. While the importance of fused cytokine receptors for the treatment of dysregulated cytokine production has already been noticed, …
-
Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
… is unknown, there are no effective treatments available. Inhibition of interleukin 6 (IL-6) results in the attenuation of pulmonary fibrosis in mice. It is unclear whether this is due to blockade of classical<em> </em>signaling, mediated by membrane-bound IL-6 receptor alpha (mIL-6Rα), or trans …