Global ETD Search
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Showing 1 to 6 of 6 for “"IL-6-type cytokine"”.
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Regulation of IL-6 signal transduction, contributions of the Signal Regulatory Protein (SIRP) and cyclic AMP
… the first time that SIRP alpha contributes to IL-6-type cytokine signalling. SIRP alpha binds to the protein tyrosine phosphatase SHP2 upon IL-6 stimulation. Mouse embryonal fibroblasts which express a SIRP alpha protein lacking the intracellular part show an enhanced SHP2 phosphorylation and …
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Ortsgerichtete Immobilisierung fluoreszenzmarkierter IL-6-Typ-Zytokine und Analyse ihrer Signaltransduktion
IL-6-type cytokines have a significant function in modulating the inflammatory response and wound healing process. They influence growth, proliferation and differentiation of various cell types. Therefore, the functionalization of biomaterial surfaces with IL-6-type cytokines permits the control of …
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Regulation of suppressor of cytokine signalling 3 expression by the pro-inflammatory cytokine (IL-1beta) in vitro and inflammatory stimuli in vivo
Interleukin-6 (IL-6) exerts pro- as well as anti-inflammatory activities in response to infection, injury or other stimuli which affect the homeostasis of the organism. IL-6-induced expression of acute phase protein genes in the liver is tightly regulated through both IL-6-induced feedback …
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Entwicklung und Charakterisierung eines IL-6-Inhibitors basierend auf Funktionsanalysen des murinen IL-6R alpha
Among other humoral factors, cytokines get secreted by a variety of cell types in response to different external stimuli and induce a multitude of biological effects. IL-6-type cytokine family members activate the Jak/STAT signalling pathway and hence modulate processes such as apoptosis, …
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Chemokinaktivität induziert durch Interleukin-6
Interleukin-6 belongs to the IL-6 type cytokine family. It signals through a receptor complex composed of the IL-6Ralpha and the signal-transducing subunit gp130. The activation of this receptor complex leads to the activation of the JAK/STAT pathway, the MAPK- and PI3K-caskade. IL-6 plays an …
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Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
To avoid overshooting cytokine signalling with possible pathological consequences, the duration as well as the intensity of the activated signal transduction pathways are tightly regulated. The importance of the feedback inhibitor suppressor of cytokine signalling 3 (SOCS3) in inhibition of the …